GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▲	GO Labels	GO IDs
GL_001667	Interleukin-2	P17108	Rattus norvegicus	10116	G protein-coupled receptor signaling pathway T cell proliferation activated T cell proliferation adaptive immune response carbohydrate binding cytokine activity extracellular space extrinsic apoptotic signaling pathway in absence of ligand gene expression glycosphingolipid binding growth factor activity interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding leukocyte activation involved in immune response lymphocyte proliferation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of protein phosphorylation positive regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol response to tacrolimus transcription by RNA polymerase II	GO:0001933 GO:0001934 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005615 GO:0006366 GO:0007186 GO:0007204 GO:0007205 GO:0008083 GO:0010467 GO:0030246 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042531 GO:0043208 GO:0045471 GO:0045582 GO:0045591 GO:0045944 GO:0046013 GO:0046651 GO:0048304 GO:0050672 GO:0050728 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:1901327 GO:2000320 GO:2000561
GL_000813	Neuronal pentraxin-2	P97738	Rattus norvegicus	10116	associative learning carbohydrate binding extrinsic component of postsynaptic specialization membrane glutamatergic synapse metal ion binding neurotransmitter receptor localization to postsynaptic specialization membrane synaptic cleft	GO:0008306 GO:0030246 GO:0043083 GO:0046872 GO:0098892 GO:0098978 GO:0099645
GL_001100	Serum amyloid P-component	P23680	Rattus norvegicus	10116	calcium ion binding carbohydrate binding complement component C1q complex binding extracellular space identical protein binding innate immune response negative regulation of glycoprotein metabolic process negative regulation of monocyte differentiation negative regulation of viral entry into host cell negative regulation of viral process protein-containing complex protein-containing complex assembly virion binding	GO:0001849 GO:0005509 GO:0005615 GO:0030246 GO:0032991 GO:0042802 GO:0045087 GO:0045656 GO:0046597 GO:0046790 GO:0048525 GO:0065003 GO:1903019
GL_001893	Zona pellucida sperm-binding protein 3	P97708	Rattus norvegicus	10116	acrosin binding binding of sperm to zona pellucida blastocyst formation carbohydrate binding collagen-containing extracellular matrix egg coat egg coat formation extracellular matrix extracellular space humoral immune response mediated by circulating immunoglobulin identical protein binding negative regulation of DNA-templated transcription negative regulation of binding of sperm to zona pellucida oocyte development plasma membrane positive regulation of DNA-templated transcription positive regulation of T cell proliferation positive regulation of acrosomal vesicle exocytosis positive regulation of acrosome reaction positive regulation of antral ovarian follicle growth positive regulation of humoral immune response positive regulation of inflammatory response positive regulation of interleukin-4 production positive regulation of leukocyte migration positive regulation of ovarian follicle development positive regulation of type II interferon production positive regulation of type IV hypersensitivity receptor ligand activity structural constituent of egg coat	GO:0001809 GO:0001825 GO:0002455 GO:0002687 GO:0002922 GO:0005615 GO:0005886 GO:0007339 GO:0030246 GO:0031012 GO:0032190 GO:0032729 GO:0032753 GO:0035803 GO:0035804 GO:0035805 GO:0042102 GO:0042802 GO:0045892 GO:0045893 GO:0048018 GO:0048599 GO:0050729 GO:0062023 GO:2000344 GO:2000360 GO:2000368 GO:2000386 GO:2000388
GL_000837	Oxidized low-density lipoprotein receptor 1	O70156	Rattus norvegicus	10116	carbohydrate binding extracellular region identical protein binding immune system process inflammatory response leukocyte cell-cell adhesion lipoprotein metabolic process low-density lipoprotein particle receptor activity membrane raft negative regulation of gene expression plasma membrane receptor complex response to hydrogen peroxide	GO:0002376 GO:0005041 GO:0005576 GO:0005886 GO:0006954 GO:0007159 GO:0010629 GO:0030246 GO:0042157 GO:0042542 GO:0042802 GO:0043235 GO:0045121
GL_000110	Brevican core protein	P55068	Rattus norvegicus	10116	GABA-ergic synapse axon axon initial segment carbohydrate binding cell surface cell-matrix adhesion central nervous system development dendrite extracellular matrix extracellular space glial cell differentiation gliogenesis glutamatergic synapse hippocampus development hyaluronic acid binding neuron projection extension node of Ranvier perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation regulation of neuronal synaptic plasticity side of membrane skeletal system development synapse synapse maturation synaptic membrane	GO:0001501 GO:0002052 GO:0005540 GO:0005615 GO:0007160 GO:0007417 GO:0009986 GO:0010001 GO:0021766 GO:0030246 GO:0030424 GO:0030425 GO:0031012 GO:0033268 GO:0042063 GO:0043194 GO:0045202 GO:0048168 GO:0060074 GO:0072534 GO:0097060 GO:0098552 GO:0098966 GO:0098978 GO:0098982 GO:1990138
GL_001236	Alpha-mannosidase 2C1	P21139	Rattus norvegicus	10116	alpha-mannosidase activity carbohydrate binding cytosol mannose metabolic process metal ion binding oligosaccharide catabolic process	GO:0004559 GO:0005829 GO:0006013 GO:0009313 GO:0030246 GO:0046872
GL_000890	Polypeptide N-acetylgalactosaminyltransferase 10	Q925R7	Rattus norvegicus	10116	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_002005	E-selectin	P98105	Rattus norvegicus	10116	actin filament-based process caveola cell adhesion clathrin-coated pit cortical cytoskeleton external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte migration leukocyte tethering or rolling membrane raft metal ion binding oligosaccharide binding perinuclear region of cytoplasm phospholipase binding plasma membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of receptor internalization response to cytokine response to interleukin-1 sialic acid binding transmembrane signaling receptor activity	GO:0002092 GO:0002687 GO:0004888 GO:0005615 GO:0005886 GO:0005901 GO:0005905 GO:0007155 GO:0007157 GO:0007159 GO:0009897 GO:0030029 GO:0030863 GO:0033691 GO:0034097 GO:0043274 GO:0045121 GO:0046872 GO:0048471 GO:0050900 GO:0050901 GO:0070492 GO:0070555 GO:1903238
GL_001416	Contactin-1	Q63198	Rattus norvegicus	10116	Notch signaling pathway axon axon guidance brain development carbohydrate binding cell-cell adhesion cell-cell adhesion mediator activity central nervous system myelin formation cerebellum development gene expression locomotory behavior myelination neuron projection development plasma membrane positive regulation of gene expression positive regulation of neuron projection development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of sodium ion transport postsynaptic membrane presynaptic membrane side of membrane	GO:0005886 GO:0007219 GO:0007411 GO:0007420 GO:0007626 GO:0010467 GO:0010628 GO:0010765 GO:0010976 GO:0021549 GO:0030246 GO:0030424 GO:0031175 GO:0032289 GO:0042552 GO:0042734 GO:0045211 GO:0050731 GO:0098552 GO:0098609 GO:0098632