GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▲	GO Labels	GO IDs
GL_000313	Chitinase-3-like protein 1	Q9WTV1	Rattus norvegicus	10116	activation of NF-kappaB-inducing kinase activity apoptotic process carbohydrate binding carbohydrate metabolic process cellular response to interleukin-1 cellular response to tumor necrosis factor chitin binding chitin catabolic process cytoplasm endoplasmic reticulum extracellular region extracellular space inflammatory response lung development perinuclear region of cytoplasm positive regulation of ERK1 and ERK2 cascade positive regulation of angiogenesis positive regulation of interleukin-8 production positive regulation of peptidyl-threonine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction response to interleukin-1 response to interleukin-6 response to mechanical stimulus response to tumor necrosis factor	GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005975 GO:0006032 GO:0006915 GO:0006954 GO:0007250 GO:0008061 GO:0009612 GO:0010800 GO:0030246 GO:0030324 GO:0032757 GO:0034612 GO:0045766 GO:0048471 GO:0051897 GO:0070374 GO:0070555 GO:0070741 GO:0071347 GO:0071356
GL_000253	Calnexin	P35565	Rattus norvegicus	10116	apolipoprotein binding axon calcium ion binding carbohydrate binding clathrin-dependent endocytosis dendrite cytoplasm dendritic spine endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum quality control compartment glutamatergic synapse ionotropic glutamate receptor binding melanosome membrane mitochondria-associated endoplasmic reticulum membrane neuronal cell body nuclear membrane postsynaptic membrane presynapse presynaptic active zone membrane protein folding protein-containing complex ribosome smooth endoplasmic reticulum synapse synaptic vesicle endocytosis ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0005509 GO:0005783 GO:0005789 GO:0005790 GO:0005840 GO:0006457 GO:0016020 GO:0030246 GO:0030424 GO:0030433 GO:0031965 GO:0032839 GO:0032991 GO:0034185 GO:0035255 GO:0042470 GO:0043025 GO:0043197 GO:0044233 GO:0044322 GO:0045202 GO:0045211 GO:0048488 GO:0048787 GO:0051082 GO:0072583 GO:0098793 GO:0098978
GL_000196	C-type lectin domain family 6 member A	D3ZWT9	Rattus norvegicus	10116	adaptive immune response antifungal innate immune response calcium ion binding carbohydrate binding defense response to fungus external side of plasma membrane innate immune response mannose binding pattern recognition receptor activity plasma membrane positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cytokine production	GO:0001819 GO:0002250 GO:0005509 GO:0005537 GO:0005886 GO:0009897 GO:0030246 GO:0038187 GO:0043123 GO:0045087 GO:0050832 GO:0061760 GO:2000318
GL_000619	Killer cell lectin-like receptor subfamily B member 1B allele C	Q5NKN2	Rattus norvegicus	10116	carbohydrate binding cell surface plasma membrane regulation of natural killer cell mediated cytotoxicity signaling receptor activity	GO:0005886 GO:0009986 GO:0030246 GO:0038023 GO:0042269
GL_001847	Tissue alpha-L-fucosidase	P17164	Rattus norvegicus	10116	alpha-L-fucosidase activity carbohydrate binding fucose metabolic process fucosidase activity glycoside catabolic process lipid metabolic process lysosome	GO:0004560 GO:0005764 GO:0006004 GO:0006629 GO:0015928 GO:0016139 GO:0030246
GL_000159	C-type lectin domain family 2 member D5	Q925N7	Rattus norvegicus	10116	carbohydrate binding cell surface endoplasmic reticulum external side of plasma membrane natural killer cell lectin-like receptor binding negative regulation of osteoclast differentiation protection from natural killer cell mediated cytotoxicity	GO:0005783 GO:0009897 GO:0009986 GO:0030246 GO:0042270 GO:0045671 GO:0046703
GL_000926	Polypeptide N-acetylgalactosaminyltransferase 5	O88422	Rattus norvegicus	10116	Golgi apparatus Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0030246 GO:0046872
GL_000633	Killer cell lectin-like receptor subfamily I member 1	Q5DT39	Rattus norvegicus	10116	carbohydrate binding external side of plasma membrane plasma membrane positive regulation of natural killer cell mediated cytotoxicity stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0004888 GO:0005886 GO:0009897 GO:0030246 GO:0045954
GL_000175	C-type lectin domain family 4 member A	Q67EQ0	Rattus norvegicus	10116	CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding defense response to fungus detection of yeast external side of plasma membrane innate immune response mannose binding negative regulation of cytokine production negative regulation of tumor necrosis factor production pattern recognition receptor activity plasmacytoid dendritic cell antigen processing and presentation positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cytokine production positive regulation of intracellular signal transduction positive regulation of peptidyl-tyrosine phosphorylation response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001818 GO:0001819 GO:0001878 GO:0001879 GO:0002223 GO:0002250 GO:0002470 GO:0005509 GO:0005537 GO:0009897 GO:0030246 GO:0032720 GO:0036037 GO:0038187 GO:0042590 GO:0043123 GO:0045087 GO:0050731 GO:0050832 GO:0061760 GO:1902533 GO:2000318
GL_000959	Prostatic spermine-binding protein	P08723	Rattus norvegicus	10116	carbohydrate binding extracellular space polyamine binding	GO:0005615 GO:0019808 GO:0030246