GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels ▲	GO IDs
GL_002009	Ficolin-2	O70497	Mus musculus	10090	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding calcium-dependent protein binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space identical protein binding mannan binding metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteoglycan binding proteolysis recognition of apoptotic cell serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0032757 GO:0033691 GO:0034394 GO:0038187 GO:0042802 GO:0043394 GO:0043654 GO:0046597 GO:0046872 GO:0048306 GO:0062023 GO:0097367 GO:1903028 GO:1905370 GO:2001065
GL_000384	Ficolin-1	O00602	Homo sapiens	9606	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway external side of plasma membrane extracellular region extracellular space ficolin-1-rich granule lumen metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell secretory granule lumen serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0009897 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0034774 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1904813 GO:1905370
GL_000390	Ficolin-2	P57756	Rattus norvegicus	10116	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1905370
GL_002343	Cation-independent mannose-6-phosphate receptor	P11717	Homo sapiens	9606	G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome endosome membrane enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
GL_000075	Attractin-like protein 1	Q5VV63	Homo sapiens	9606	G protein-coupled receptor signaling pathway Notch binding carbohydrate binding membrane	GO:0005112 GO:0007186 GO:0016020 GO:0030246
GL_000074	Attractin-like protein 1	Q6A051	Mus musculus	10090	G protein-coupled receptor signaling pathway Notch binding carbohydrate binding plasma membrane	GO:0005112 GO:0005886 GO:0007186 GO:0030246
GL_001667	Interleukin-2	P17108	Rattus norvegicus	10116	G protein-coupled receptor signaling pathway T cell proliferation activated T cell proliferation adaptive immune response carbohydrate binding cytokine activity extracellular space extrinsic apoptotic signaling pathway in absence of ligand gene expression glycosphingolipid binding growth factor activity interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding leukocyte activation involved in immune response lymphocyte proliferation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of protein phosphorylation positive regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol response to tacrolimus transcription by RNA polymerase II	GO:0001933 GO:0001934 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005615 GO:0006366 GO:0007186 GO:0007204 GO:0007205 GO:0008083 GO:0010467 GO:0030246 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042531 GO:0043208 GO:0045471 GO:0045582 GO:0045591 GO:0045944 GO:0046013 GO:0046651 GO:0048304 GO:0050672 GO:0050728 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:1901327 GO:2000320 GO:2000561
GL_001665	Interleukin-2	P04351	Mus musculus	10090	G protein-coupled receptor signaling pathway T cell proliferation activated T cell proliferation adaptive immune response carbohydrate binding cytokine activity extracellular space extrinsic apoptotic signaling pathway in absence of ligand gene expression glycosphingolipid binding growth factor activity interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding leukocyte activation involved in immune response lymphocyte proliferation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of protein phosphorylation positive regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol transcription by RNA polymerase II	GO:0001933 GO:0001934 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005615 GO:0006366 GO:0007186 GO:0007204 GO:0007205 GO:0008083 GO:0010467 GO:0030246 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042531 GO:0043208 GO:0045471 GO:0045582 GO:0045591 GO:0045944 GO:0046013 GO:0046651 GO:0048304 GO:0050672 GO:0050728 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:2000320 GO:2000561
GL_000385	Ficolin-1	O70165	Mus musculus	10090	G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space metal ion binding pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0007186 GO:0030246 GO:0032757 GO:0038187 GO:0046872 GO:0062023 GO:0097367
GL_000387	Ficolin-1	Q9WTS8	Rattus norvegicus	10116	G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space metal ion binding pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0007186 GO:0030246 GO:0032757 GO:0038187 GO:0046872 GO:0062023 GO:0097367