GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs ▲
GL_002059	Protein OS-9 homolog	Q99220	Saccharomyces cerevisiae S288C	559292	Hrd1p ubiquitin ligase ERAD-L complex Hrd1p ubiquitin ligase complex detection of unfolded protein endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response identical protein binding luminal surveillance complex oligosaccharide binding retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway ubiquitin-dependent glycoprotein ERAD pathway	GO:0000836 GO:0000839 GO:0002235 GO:0005783 GO:0005788 GO:0005789 GO:0030433 GO:0030968 GO:0030970 GO:0034099 GO:0042802 GO:0070492 GO:0097466
GL_000990	Protein OS-9	Q13438	Homo sapiens	9606	Hrd1p ubiquitin ligase complex carbohydrate binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response negative regulation of retrograde protein transport, ER to cytosol protease binding protein retention in ER lumen protein targeting protein ubiquitination response to endoplasmic reticulum stress retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway ubiquitin-dependent protein catabolic process	GO:0000836 GO:0002020 GO:0005783 GO:0005788 GO:0005789 GO:0006511 GO:0006605 GO:0006621 GO:0016567 GO:0030246 GO:0030433 GO:0030968 GO:0030970 GO:0034976 GO:1904153
GL_001852	Transcriptional regulator LsrR	P76141	Escherichia coli K-12	83333	DNA-templated transcription carbohydrate binding cis-regulatory region sequence-specific DNA binding cytosol identical protein binding regulation of DNA-templated transcription initiation response to heat	GO:0000987 GO:0005829 GO:0006351 GO:0009408 GO:0030246 GO:0042802 GO:2000142
GL_000052	Aggrecan core protein	P07897	Rattus norvegicus	10116	GABA-ergic synapse basement membrane calcium ion binding carbohydrate binding cartilage condensation cell adhesion cellular response to growth factor stimulus central nervous system development chondroblast differentiation chondrocyte development collagen fibril organization extracellular matrix extracellular space glial cell differentiation glutamatergic synapse heart development hyaluronic acid binding negative regulation of cell migration neuronal cell body ossification perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation proteoglycan biosynthetic process response to acidic pH response to glucose response to gravity response to mechanical stimulus response to organic cyclic compound response to xenobiotic stimulus skeletal system development spinal cord development synapse	GO:0001501 GO:0001502 GO:0001503 GO:0002052 GO:0002063 GO:0005509 GO:0005540 GO:0005604 GO:0005615 GO:0007155 GO:0007417 GO:0007507 GO:0009410 GO:0009612 GO:0009629 GO:0009749 GO:0010001 GO:0010447 GO:0014070 GO:0021510 GO:0030166 GO:0030199 GO:0030246 GO:0030336 GO:0031012 GO:0043025 GO:0045202 GO:0060591 GO:0071363 GO:0072534 GO:0098966 GO:0098978 GO:0098982
GL_000048	Aggrecan core protein	Q61282	Mus musculus	10090	GABA-ergic synapse basement membrane calcium ion binding carbohydrate binding cartilage condensation cell adhesion central nervous system development chondrocyte development collagen fibril organization extracellular matrix extracellular space glial cell differentiation glutamatergic synapse heart development hyaluronic acid binding negative regulation of cell migration neuronal cell body perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation proteoglycan biosynthetic process skeletal system development synapse	GO:0001501 GO:0001502 GO:0002052 GO:0002063 GO:0005509 GO:0005540 GO:0005604 GO:0005615 GO:0007155 GO:0007417 GO:0007507 GO:0010001 GO:0030166 GO:0030199 GO:0030246 GO:0030336 GO:0031012 GO:0043025 GO:0045202 GO:0072534 GO:0098966 GO:0098978 GO:0098982
GL_001145	Tetranectin	P43025	Mus musculus	10090	bone mineralization calcium ion binding carbohydrate binding cytoplasm extracellular matrix extracellular space granular component heparin binding kringle domain binding ossification positive regulation of plasminogen activation skeletal system development	GO:0001501 GO:0001503 GO:0001652 GO:0005509 GO:0005615 GO:0005737 GO:0008201 GO:0010756 GO:0030246 GO:0030282 GO:0031012 GO:0036143
GL_000169	C-type lectin domain family 3 member A	O75596	Homo sapiens	9606	carbohydrate binding extracellular space ossification skeletal system development	GO:0001501 GO:0001503 GO:0005615 GO:0030246
GL_000494	Galectin-3	P16110	Mus musculus	10090	Fc-gamma receptor I complex binding IgE binding RNA splicing advanced glycation end-product receptor activity antimicrobial humoral immune response mediated by antimicrobial peptide carbohydrate binding cell differentiation cell surface chemoattractant activity collagen-containing extracellular matrix cornified envelope cytoplasm cytosol disaccharide binding eosinophil chemotaxis external side of plasma membrane extracellular matrix extracellular matrix organization extracellular region extracellular space glial cell projection immunological synapse innate immune response killing of cells of another organism laminin binding mRNA processing macrophage chemotaxis mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration monosaccharide binding negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of apoptotic process negative regulation of cell proliferation in bone marrow negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation neutrophil chemotaxis nucleoplasm nucleus oligosaccharide binding positive chemotaxis positive regulation of angiogenesis positive regulation of calcium ion import positive regulation of cell population proliferation positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly positive regulation of serotonin secretion protein phosphatase binding regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors skeletal system development spliceosomal complex	GO:0001501 GO:0001533 GO:0001772 GO:0002548 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005743 GO:0005829 GO:0006397 GO:0008284 GO:0008380 GO:0009897 GO:0009986 GO:0014064 GO:0019863 GO:0019903 GO:0030154 GO:0030198 GO:0030246 GO:0030593 GO:0031012 GO:0031334 GO:0031640 GO:0034988 GO:0042056 GO:0042129 GO:0043066 GO:0043236 GO:0045087 GO:0045766 GO:0045806 GO:0048029 GO:0048030 GO:0048245 GO:0048246 GO:0050785 GO:0050860 GO:0050918 GO:0061844 GO:0062023 GO:0070232 GO:0070492 GO:0071674 GO:0071677 GO:0090280 GO:0097386 GO:0140693 GO:1902041 GO:1903078 GO:1903769 GO:2000521 GO:2001189 GO:2001237
GL_000495	Galectin-3	P08699	Rattus norvegicus	10116	Fc-gamma receptor I complex binding IgE binding RNA splicing advanced glycation end-product receptor activity carbohydrate binding cell surface chemoattractant activity cornified envelope cytoplasm disaccharide binding eosinophil chemotaxis epithelial cell differentiation external side of plasma membrane extracellular matrix extracellular matrix organization extracellular space glial cell projection immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration monosaccharide binding negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of apoptotic process negative regulation of cell proliferation in bone marrow negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation neutrophil chemotaxis nucleus plasma membrane positive chemotaxis positive regulation of angiogenesis positive regulation of calcium ion import positive regulation of cell population proliferation positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly positive regulation of serotonin secretion protein phosphatase binding regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors response to quercetin skeletal system development spliceosomal complex	GO:0001501 GO:0001533 GO:0001772 GO:0002548 GO:0005615 GO:0005634 GO:0005681 GO:0005737 GO:0005743 GO:0005886 GO:0006397 GO:0008284 GO:0008380 GO:0009897 GO:0009986 GO:0014064 GO:0019863 GO:0019903 GO:0030198 GO:0030246 GO:0030593 GO:0030855 GO:0031012 GO:0031334 GO:0034988 GO:0042056 GO:0042129 GO:0043066 GO:0043236 GO:0045087 GO:0045766 GO:0045806 GO:0048029 GO:0048030 GO:0048245 GO:0048246 GO:0050785 GO:0050860 GO:0050918 GO:0070232 GO:0071674 GO:0071677 GO:0090280 GO:0097386 GO:0140693 GO:1902041 GO:1903078 GO:1903769 GO:1905235 GO:2000521 GO:2001189 GO:2001237
GL_001169	Versican core protein	P13611	Homo sapiens	9606	Golgi lumen calcium ion binding carbohydrate binding cell adhesion cell recognition central nervous system development collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix extracellular matrix structural constituent conferring compression resistance extracellular region extracellular space glial cell differentiation glial cell migration glycosaminoglycan binding hyaluronic acid binding interphotoreceptor matrix lysosomal lumen membrane osteoblast differentiation perineuronal net photoreceptor outer segment positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0001649 GO:0001750 GO:0002052 GO:0005509 GO:0005539 GO:0005540 GO:0005576 GO:0005615 GO:0005788 GO:0005796 GO:0007155 GO:0007417 GO:0008037 GO:0008347 GO:0010001 GO:0016020 GO:0030021 GO:0030246 GO:0031012 GO:0033165 GO:0043202 GO:0045202 GO:0062023 GO:0072534