GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs ▲
GL_002347	Neural cell adhesion molecule 1	P13591	Homo sapiens	9606	Golgi membrane cell adhesion cell surface collagen-containing extracellular matrix commissural neuron axon guidance cytosol epithelial to mesenchymal transition external side of plasma membrane extracellular region membrane plasma membrane regulation of semaphorin-plexin signaling pathway virus receptor activity	GO:0000139 GO:0001618 GO:0001837 GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0062023 GO:0071679 GO:2001260
GL_001230	Alpha-mannosidase 2	P28494	Rattus norvegicus	10116	Golgi apparatus Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular space hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds identical protein binding in utero embryonic development liver development lung alveolus development mannose metabolic process mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization zinc ion binding	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005615 GO:0005794 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0008270 GO:0015923 GO:0016787 GO:0016799 GO:0030246 GO:0042802 GO:0042803 GO:0048286 GO:0050769 GO:0060042
GL_001232	Alpha-mannosidase 2	P27046	Mus musculus	10090	Golgi apparatus Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular space hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds identical protein binding in utero embryonic development liver development lung alveolus development mannose metabolic process mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005615 GO:0005794 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0015923 GO:0016787 GO:0016799 GO:0030246 GO:0042802 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042
GL_001231	Alpha-mannosidase 2	Q16706	Homo sapiens	9606	Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular exosome hydrolase activity, hydrolyzing N-glycosyl compounds in utero embryonic development liver development lung alveolus development mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity membrane metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization viral protein processing	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0016020 GO:0016799 GO:0019082 GO:0030246 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042 GO:0070062
GL_002343	Cation-independent mannose-6-phosphate receptor	P11717	Homo sapiens	9606	G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome endosome membrane enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
GL_001999	Comitin	Q03380	Dictyostelium discoideum	44689	Golgi apparatus Golgi membrane Golgi-associated vesicle membrane actin filament binding actin filament bundle assembly actin monomer binding cell-cell junction cytoskeleton defense response to bacterium endosome hyperosmotic response identical protein binding lipid droplet mannose binding phagocytic vesicle phagocytosis response to bacterium response to cAMP response to cycloheximide response to other organism rough endoplasmic reticulum membrane	GO:0000139 GO:0003785 GO:0005537 GO:0005768 GO:0005794 GO:0005811 GO:0005856 GO:0005911 GO:0006909 GO:0006972 GO:0009617 GO:0030660 GO:0030867 GO:0042742 GO:0042802 GO:0045335 GO:0046898 GO:0051015 GO:0051017 GO:0051591 GO:0051707
GL_001228	Alpha-mannosidase 2	Q24451	Drosophila melanogaster	7227	Golgi membrane Golgi stack N-glycan processing alpha-mannosidase activity carbohydrate binding encapsulation of foreign target endoplasmic reticulum mannose metabolic process mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein deglycosylation protein glycosylation rhodopsin biosynthetic process	GO:0000139 GO:0004559 GO:0004572 GO:0005783 GO:0005795 GO:0006013 GO:0006486 GO:0006491 GO:0006517 GO:0015923 GO:0016063 GO:0030246 GO:0035010 GO:0046872
GL_001237	Alpha-mannosidase 2x	Q8BRK9	Mus musculus	10090	Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding hydrolase activity, hydrolyzing N-glycosyl compounds mannose metabolic process mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004559 GO:0004572 GO:0006013 GO:0006486 GO:0006491 GO:0015923 GO:0016799 GO:0030246 GO:0046872
GL_001238	Alpha-mannosidase 2x	P49641	Homo sapiens	9606	Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding hydrolase activity, hydrolyzing N-glycosyl compounds mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004559 GO:0004572 GO:0006013 GO:0006486 GO:0006491 GO:0016799 GO:0030246 GO:0046872
GL_001233	Alpha-mannosidase 2	O18497	Spodoptera frugiperda	7108	Golgi membrane N-glycan processing carbohydrate binding endoplasmic reticulum mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004572 GO:0005783 GO:0006013 GO:0006486 GO:0006491 GO:0030246 GO:0046872