GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	March 3, 2025
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **26 - 50** of **297** in total

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GlyCosmos Lectin ▼	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_004572	Beta-mannosidase	O00462		Homo sapiens (human)	9606	azurophil granule membrane beta-mannosidase activity glycoprotein catabolic process lysosomal lumen mannose binding oligosaccharide catabolic process plasma membrane protein modification process	GO:0004567 GO:0005537 GO:0005886 GO:0006516 GO:0009313 GO:0035577 GO:0036211 GO:0043202
GL_004553	Bis(monoacylglycero)phosphate synthase CLN5	O75503	6R99	Homo sapiens (human)	9606	Golgi apparatus bis(monoacylglycero)phosphate synthase activity brain development cytosol endoplasmic reticulum extracellular exosome glycosylation hydrolase activity, acting on glycosyl bonds long-chain acyl-CoA hydrolase activity lysosomal lumen acidification lysosomal membrane lysosome organization lysosome mannose binding membrane neurogenesis neuron maturation perinuclear region of cytoplasm positive regulation of GTP binding protein catabolic process retrograde transport, endosome to Golgi signal peptide processing vacuolar lumen visual perception	GO:0005537 GO:0005764 GO:0005765 GO:0005775 GO:0005783 GO:0005794 GO:0005829 GO:0006465 GO:0007040 GO:0007042 GO:0007420 GO:0007601 GO:0016020 GO:0016798 GO:0022008 GO:0030163 GO:0042147 GO:0042551 GO:0048471 GO:0052816 GO:0070062 GO:0070085 GO:0160121 GO:1904426
GL_004531	Solute carrier family 2, facilitated glucose transporter member 5	P22732		Homo sapiens (human)	9606	apical plasma membrane carbohydrate metabolic process cellular response to fructose stimulus extracellular exosome fructose binding fructose import across plasma membrane fructose transmembrane transport fructose transmembrane transporter activity glucose transmembrane transport glucose transmembrane transporter activity intestinal hexose absorption plasma membrane regulation of systemic arterial blood pressure mediated by a chemical signal response to fructose sarcolemma specific granule membrane	GO:0003044 GO:0005353 GO:0005355 GO:0005886 GO:0005975 GO:0009750 GO:0015755 GO:0016324 GO:0035579 GO:0042383 GO:0070061 GO:0070062 GO:0071332 GO:0106001 GO:1904659 GO:1990539
GL_004526	Fructose-bisphosphate aldolase A	P04075	1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO	Homo sapiens (human)	9606	ATP biosynthetic process I band M band RNA binding actin binding actin cytoskeleton actin filament organization binding of sperm to zona pellucida cadherin binding cytoskeletal protein binding cytosol extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen fructose 1,6-bisphosphate metabolic process fructose binding fructose metabolic process fructose-bisphosphate aldolase activity glycolytic process identical protein binding membrane muscle cell cellular homeostasis nucleus platelet alpha granule lumen protein homotetramerization regulation of cell shape secretory granule lumen sperm head striated muscle contraction tertiary granule lumen tubulin binding	GO:0003723 GO:0003779 GO:0004332 GO:0005576 GO:0005615 GO:0005634 GO:0005829 GO:0006000 GO:0006096 GO:0006754 GO:0006941 GO:0007015 GO:0007339 GO:0008092 GO:0008360 GO:0015629 GO:0015631 GO:0016020 GO:0030388 GO:0031093 GO:0031430 GO:0031674 GO:0034774 GO:0042802 GO:0045296 GO:0046716 GO:0051289 GO:0061827 GO:0070061 GO:0070062 GO:1904724 GO:1904813
GL_004522	Fructose-bisphosphate aldolase B	P05062	1QO5 1XDL 1XDM 8D44	Homo sapiens (human)	9606	ATPase binding NADH oxidation centriolar satellite cytoskeletal protein binding cytosol extracellular exosome fructose 1,6-bisphosphate metabolic process fructose binding fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate fructose metabolic process fructose-1-phosphate aldolase activity fructose-bisphosphate aldolase activity gluconeogenesis glycolytic process identical protein binding microtubule organizing center molecular adaptor activity negative regulation of pentose-phosphate shunt positive regulation of ATP-dependent activity vacuolar proton-transporting V-type ATPase complex assembly	GO:0004332 GO:0005815 GO:0005829 GO:0006000 GO:0006094 GO:0006096 GO:0006116 GO:0008092 GO:0030388 GO:0032781 GO:0034451 GO:0042802 GO:0051117 GO:0060090 GO:0061609 GO:0061624 GO:0070061 GO:0070062 GO:0070072 GO:1905856
GL_004218	Glucose-6-phosphate isomerase	P06744	1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI 8BBH 8P2K	Homo sapiens (human)	9606	carbohydrate derivative binding carbohydrate metabolic process ciliary membrane cytokine activity cytosol erythrocyte homeostasis extracellular exosome extracellular region ficolin-1-rich granule lumen fructose 6-phosphate metabolic process gluconeogenesis glucose 6-phosphate metabolic process glucose homeostasis glucose-6-phosphate isomerase activity glycolytic process growth factor activity hemostasis humoral immune response in utero embryonic development learning or memory membrane mesoderm formation monosaccharide binding negative regulation of neuron apoptotic process positive regulation of endothelial cell migration positive regulation of immunoglobulin production response to cadmium ion response to estradiol response to immobilization stress response to muscle stretch response to progesterone response to testosterone secretory granule lumen ubiquitin protein ligase binding	GO:0001701 GO:0001707 GO:0002639 GO:0004347 GO:0005125 GO:0005576 GO:0005829 GO:0005975 GO:0006002 GO:0006094 GO:0006096 GO:0006959 GO:0007599 GO:0007611 GO:0008083 GO:0010595 GO:0016020 GO:0031625 GO:0032355 GO:0032570 GO:0033574 GO:0034101 GO:0034774 GO:0035902 GO:0035994 GO:0042593 GO:0043524 GO:0046686 GO:0048029 GO:0051156 GO:0060170 GO:0070062 GO:0097367 GO:1904813
GL_004020	Transaldolase	P37837	1F05	Homo sapiens (human)	9606	carbohydrate metabolic process cytoplasm cytosol extracellular exosome fructose 6-phosphate metabolic process monosaccharide binding nucleus pentose-phosphate shunt, non-oxidative branch transaldolase activity	GO:0004801 GO:0005634 GO:0005737 GO:0005829 GO:0005975 GO:0006002 GO:0009052 GO:0048029 GO:0070062
GL_003956	ATP-dependent 6-phosphofructokinase, platelet type	Q01813	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2 7TFF	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding cadherin binding canonical glycolysis cellular response to leukemia inhibitory factor cytoplasm cytosol extracellular exosome fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose-6-phosphate binding identical protein binding membrane metal ion binding monosaccharide binding nucleus protein-containing complex binding	GO:0003872 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0005945 GO:0006002 GO:0016020 GO:0016208 GO:0030388 GO:0042802 GO:0044877 GO:0045296 GO:0046872 GO:0048029 GO:0061621 GO:0070062 GO:0070095 GO:1990830
GL_003892	ATP-dependent 6-phosphofructokinase, muscle type	P08237	4OMT	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding apical plasma membrane canonical glycolysis cytosol fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose binding fructose-6-phosphate binding glucose homeostasis glycogen catabolic process glycolysis from storage polysaccharide through glucose-1-phosphate glycolytic process through fructose-6-phosphate glycolytic process identical protein binding kinase binding membrane metal ion binding monosaccharide binding muscle cell cellular homeostasis nucleus positive regulation of insulin secretion positive regulation of transcription by RNA polymerase II sperm principal piece	GO:0003872 GO:0005524 GO:0005634 GO:0005829 GO:0005945 GO:0005980 GO:0006002 GO:0006096 GO:0016020 GO:0016208 GO:0016324 GO:0019900 GO:0030388 GO:0032024 GO:0042593 GO:0042802 GO:0045944 GO:0046716 GO:0046872 GO:0048029 GO:0061615 GO:0061621 GO:0070061 GO:0070095 GO:0093001 GO:0097228
GL_003651	ATP-dependent 6-phosphofructokinase, liver type	P17858	7LW1	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding canonical glycolysis cytosol extracellular exosome extracellular region ficolin-1-rich granule lumen fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose binding fructose-6-phosphate binding glycolytic process identical protein binding kinase binding membrane metal ion binding monosaccharide binding negative regulation of insulin secretion response to glucose secretory granule lumen	GO:0003872 GO:0005524 GO:0005576 GO:0005829 GO:0005945 GO:0006002 GO:0006096 GO:0009749 GO:0016020 GO:0016208 GO:0019900 GO:0030388 GO:0034774 GO:0042802 GO:0046676 GO:0046872 GO:0048029 GO:0061621 GO:0070061 GO:0070062 GO:0070095 GO:1904813
GL_003444	Alpha-protein kinase 1	Q96QP1	5Z2C	Homo sapiens (human)	9606	ATP binding centrosome cilium assembly cilium cytoplasmic pattern recognition receptor signaling pathway cytosol histone H2AS1 kinase activity innate immune response monosaccharide binding positive regulation of canonical NF-kappaB signal transduction protein phosphorylation protein serine kinase activity protein serine/threonine kinase activity spindle pole	GO:0000922 GO:0002753 GO:0004674 GO:0005524 GO:0005813 GO:0005829 GO:0005929 GO:0006468 GO:0043123 GO:0044024 GO:0045087 GO:0048029 GO:0060271 GO:0106310
GL_003438	Ribose-5-phosphate isomerase	P49247		Homo sapiens (human)	9606	D-ribose metabolic process cytoplasm cytosol identical protein binding mitochondrion monosaccharide binding pentose-phosphate shunt, non-oxidative branch pentose-phosphate shunt ribose-5-phosphate isomerase activity	GO:0004751 GO:0005737 GO:0005739 GO:0005829 GO:0006014 GO:0006098 GO:0009052 GO:0042802 GO:0048029
GL_003393	Fructose-1,6-bisphosphatase 1	P09467	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB	Homo sapiens (human)	9606	AMP binding RNA polymerase II-specific DNA-binding transcription factor binding cellular hyperosmotic salinity response cellular hypotonic salinity response cellular response to cAMP cellular response to insulin stimulus cellular response to magnesium ion cellular response to phorbol 13-acetate 12-myristate cellular response to raffinose cellular response to xenobiotic stimulus cytoplasm cytosol dephosphorylation extracellular exosome fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose metabolic process gluconeogenesis identical protein binding metal ion binding monosaccharide binding negative regulation of Ras protein signal transduction negative regulation of cell growth negative regulation of glycolytic process negative regulation of transcription by RNA polymerase II nucleus regulation of gluconeogenesis response to nutrient levels sucrose biosynthetic process	GO:0000122 GO:0005634 GO:0005737 GO:0005829 GO:0005986 GO:0006000 GO:0006002 GO:0006094 GO:0006111 GO:0016208 GO:0016311 GO:0030308 GO:0030388 GO:0031667 GO:0032869 GO:0042132 GO:0042802 GO:0045820 GO:0046580 GO:0046872 GO:0048029 GO:0061629 GO:0070062 GO:0071286 GO:0071320 GO:0071466 GO:0071475 GO:0071477 GO:0097403 GO:1904628
GL_003353	Pyruvate kinase PKLR	P30613	2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCG 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 6NN4 6NN5 6NN7 6NN8 7FRV 7FRW 7FRX 7FRY 7FRZ 7FS0 7FS1 7FS2 7FS3 7FS4 7FS5 7FS6 7FS7 7FS8 7FS9 7FSA 7FSB 7FSC 7FSD 7QDN 7QZU 8TBS 8TBT 8TBU 8XFD	Homo sapiens (human)	9606	ATP binding cellular response to epinephrine stimulus cellular response to insulin stimulus cytoplasm cytosol extracellular exosome glycolytic process kinase activity magnesium ion binding monosaccharide binding phosphorylation potassium ion binding pyruvate biosynthetic process pyruvate kinase activity pyruvate kinase complex response to ATP response to cAMP response to glucose response to hypoxia response to metal ion response to nutrient	GO:0000287 GO:0001666 GO:0004743 GO:0005524 GO:0005737 GO:0005829 GO:0006096 GO:0007584 GO:0009749 GO:0010038 GO:0016301 GO:0016310 GO:0030955 GO:0032869 GO:0033198 GO:0042866 GO:0048029 GO:0051591 GO:0070062 GO:0071872 GO:1902912
GL_003320	Fucose mutarotase	A2VDF0		Homo sapiens (human)	9606	L-fucose mutarotase activity cytosol fucose binding fucose metabolic process fucosylation racemase and epimerase activity, acting on carbohydrates and derivatives	GO:0005829 GO:0006004 GO:0016857 GO:0036065 GO:0036373 GO:0042806
GL_003257	Acrosin	P10323		Homo sapiens (human)	9606	DNA binding Golgi-associated vesicle acrosomal matrix acrosome matrix dispersal acrosome reaction activation of adenylate cyclase activity amidase activity binding of sperm to zona pellucida copper ion binding extracellular region fucose binding mannose binding nucleus penetration of zona pellucida protease binding protein-containing complex response to steroid hormone serine-type endopeptidase activity serine-type peptidase activity single fertilization zinc ion binding	GO:0002020 GO:0002077 GO:0003677 GO:0004040 GO:0004252 GO:0005507 GO:0005537 GO:0005576 GO:0005634 GO:0005798 GO:0007190 GO:0007338 GO:0007339 GO:0007340 GO:0007341 GO:0008236 GO:0008270 GO:0032991 GO:0042806 GO:0043159 GO:0048545
GL_003251	C-type lectin domain family 17, member A	Q6ZS10		Homo sapiens (human)	9606	cell surface external side of plasma membrane fucose binding identical protein binding mannose binding metal ion binding	GO:0005537 GO:0009897 GO:0009986 GO:0042802 GO:0042806 GO:0046872
GL_003205	Glycerophosphocholine phosphodiesterase GPCPD1	Q9NPB8	2Z0B	Homo sapiens (human)	9606	cytosol glycerophosphocholine phosphodiesterase activity glycerophospholipid catabolic process skeletal muscle tissue development starch binding	GO:0005829 GO:0007519 GO:0046475 GO:0047389 GO:2001070
GL_003163	Protein phosphatase 1 regulatory subunit 3G	B7ZBB8		Homo sapiens (human)	9606	glucose homeostasis glycogen binding glycogen biosynthetic process positive regulation of glycogen biosynthetic process protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005978 GO:0005979 GO:0008157 GO:0042593 GO:0045725 GO:2001069
GL_003161	Protein phosphatase 1 regulatory subunit 3D	O95685		Homo sapiens (human)	9606	glycogen binding glycogen granule glycogen metabolic process protein phosphatase 1 binding protein phosphatase type 1 complex protein serine/threonine phosphatase activity regulation of glycogen biosynthetic process regulation of glycogen catabolic process	GO:0000164 GO:0004722 GO:0005977 GO:0005979 GO:0005981 GO:0008157 GO:0042587 GO:2001069
GL_003160	Protein phosphatase 1 regulatory subunit 3B	Q86XI6	2EEF 5ZT0	Homo sapiens (human)	9606	[phosphorylase] phosphatase activity glycogen binding glycogen granule glycogen metabolic process negative regulation of glycogen catabolic process positive regulation of glycogen biosynthetic process protein phosphatase 1 binding protein phosphatase regulator activity protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005977 GO:0005979 GO:0008157 GO:0019888 GO:0042587 GO:0045725 GO:0045818 GO:0050196 GO:2001069
GL_003157	Protein phosphatase 1 regulatory subunit 3A	Q16821	5ZQV	Homo sapiens (human)	9606	glycogen binding glycogen metabolic process membrane protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005977 GO:0005979 GO:0008157 GO:0016020 GO:2001069
GL_003155	Protein phosphatase 1 regulatory subunit 3E	Q9H7J1		Homo sapiens (human)	9606	[phosphorylase] phosphatase activity glycogen binding glycogen granule glycogen metabolic process positive regulation of glycogen biosynthetic process protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005977 GO:0005979 GO:0008157 GO:0042587 GO:0045725 GO:0050196 GO:2001069
GL_003151	Protein phosphatase 1 regulatory subunit 3F	Q6ZSY5		Homo sapiens (human)	9606	glycogen binding membrane protein phosphatase 1 binding protein phosphatase binding protein phosphatase type 1 complex regulation of glycogen (starch) synthase activity regulation of glycogen biosynthetic process	GO:0000164 GO:0005979 GO:0008157 GO:0016020 GO:0019903 GO:2000465 GO:2001069
GL_003145	Protein phosphatase 1 regulatory subunit 3C	Q9UQK1	7QF7 7QFA 7QFB 7QM2	Homo sapiens (human)	9606	cytosol glycogen binding glycogen biosynthetic process glycogen metabolic process molecular adaptor activity protein phosphatase 1 binding protein phosphatase binding protein phosphatase type 1 complex protein serine/threonine phosphatase activity regulation of glycogen biosynthetic process	GO:0000164 GO:0004722 GO:0005829 GO:0005977 GO:0005978 GO:0005979 GO:0008157 GO:0019903 GO:0060090 GO:2001069

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