GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **26 - 50** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_003892	ATP-dependent 6-phosphofructokinase, muscle type	P08237	4OMT	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding apical plasma membrane canonical glycolysis cytosol fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose binding fructose-6-phosphate binding glucose homeostasis glycogen catabolic process glycolysis from storage polysaccharide through glucose-1-phosphate glycolytic process through fructose-6-phosphate glycolytic process identical protein binding kinase binding membrane metal ion binding monosaccharide binding muscle cell cellular homeostasis nucleus positive regulation of insulin secretion positive regulation of transcription by RNA polymerase II sperm principal piece	GO:0003872 GO:0005524 GO:0005634 GO:0005829 GO:0005945 GO:0005980 GO:0006002 GO:0006096 GO:0016020 GO:0016208 GO:0016324 GO:0019900 GO:0030388 GO:0032024 GO:0042593 GO:0042802 GO:0045944 GO:0046716 GO:0046872 GO:0048029 GO:0061615 GO:0061621 GO:0070061 GO:0070095 GO:0093001 GO:0097228
GL_000139	C-type lectin domain family 10 member A	Q8IUN9	6PUV 6PY1 6W12 6XIY	Homo sapiens (human)	9606	adaptive immune response carbohydrate binding endocytosis external side of plasma membrane fucose binding innate immune response mannose binding plasma membrane signaling receptor activity	GO:0002250 GO:0005537 GO:0005886 GO:0006897 GO:0009897 GO:0030246 GO:0038023 GO:0042806 GO:0045087
GL_001835	Sorbitol dehydrogenase	Q00796	1PL6 1PL7 1PL8	Homo sapiens (human)	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_002601	Glycogen [starch] synthase, muscle	P13807	7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ	Homo sapiens (human)	9606	cytoplasm cytosol glucose binding glycogen (starch) synthase activity glycogen biosynthetic process glycogen synthase activity, transferring glucose-1-phosphate heart development inclusion body membrane	GO:0004373 GO:0005536 GO:0005737 GO:0005829 GO:0005978 GO:0007507 GO:0016020 GO:0016234 GO:0061547
GL_002410	Paired immunoglobulin-like type 2 receptor beta	Q9UKJ0	4NFC 4NFD	Homo sapiens (human)	9606	MHC class I protein binding activation of transmembrane receptor protein tyrosine kinase activity plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway	GO:0005886 GO:0007169 GO:0007171 GO:0042288
GL_002481	Hexokinase-3	P52790	3HM8	Homo sapiens (human)	9606	ATP binding canonical glycolysis carbohydrate phosphorylation cytosol extracellular region ficolin-1-rich granule lumen fructokinase activity fructose 6-phosphate metabolic process glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process hexokinase activity intracellular glucose homeostasis mannokinase activity mitochondrion secretory granule lumen	GO:0001678 GO:0004340 GO:0004396 GO:0005524 GO:0005536 GO:0005576 GO:0005739 GO:0005829 GO:0006002 GO:0006006 GO:0006096 GO:0008865 GO:0019158 GO:0034774 GO:0046835 GO:0051156 GO:0061621 GO:1904813
GL_001781	Protein AMBP	P02760	1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD	Homo sapiens (human)	9606	IgA binding blood microparticle calcium channel inhibitor activity calcium oxalate binding carbohydrate binding cell adhesion cell surface collagen-containing extracellular matrix cytosol endoplasmic reticulum extracellular exosome extracellular region extracellular space female pregnancy heme binding heme catabolic process mitochondrial inner membrane negative regulation of JNK cascade negative regulation of immune response nuclear membrane oxidoreductase activity plasma membrane protein homodimerization activity serine-type endopeptidase inhibitor activity	GO:0004867 GO:0005576 GO:0005615 GO:0005743 GO:0005783 GO:0005829 GO:0005886 GO:0007155 GO:0007565 GO:0009986 GO:0016491 GO:0019855 GO:0019862 GO:0020037 GO:0030246 GO:0031965 GO:0042167 GO:0042803 GO:0046329 GO:0046904 GO:0050777 GO:0062023 GO:0070062 GO:0072562
GL_004531	Solute carrier family 2, facilitated glucose transporter member 5	P22732		Homo sapiens (human)	9606	apical plasma membrane carbohydrate metabolic process cellular response to fructose stimulus extracellular exosome fructose binding fructose import across plasma membrane fructose transmembrane transport fructose transmembrane transporter activity glucose transmembrane transport glucose transmembrane transporter activity intestinal hexose absorption membrane plasma membrane regulation of systemic arterial blood pressure mediated by a chemical signal response to fructose sarcolemma specific granule membrane	GO:0003044 GO:0005353 GO:0005355 GO:0005886 GO:0005975 GO:0009750 GO:0015755 GO:0016020 GO:0016324 GO:0035579 GO:0042383 GO:0070061 GO:0070062 GO:0071332 GO:0106001 GO:1904659 GO:1990539
GL_002768	Starch-binding domain-containing protein 1	O95210		Homo sapiens (human)	9606	T-tubule cargo receptor activity endoplasmic reticulum membrane endoplasmic reticulum enzyme binding ficolin-1-rich granule membrane glycogen binding glycogen catabolic process glycophagy intracellular transport membrane perinuclear region of cytoplasm phagophore assembly site membrane plasma membrane polysaccharide binding starch binding substrate localization to autophagosome tertiary granule membrane	GO:0005783 GO:0005789 GO:0005886 GO:0005980 GO:0016020 GO:0019899 GO:0030247 GO:0030315 GO:0034045 GO:0038024 GO:0046907 GO:0048471 GO:0061723 GO:0061753 GO:0070821 GO:0101003 GO:2001069 GO:2001070
GL_000169	C-type lectin domain family 3 member A	O75596		Homo sapiens (human)	9606	carbohydrate binding extracellular space ossification skeletal system development	GO:0001501 GO:0001503 GO:0005615 GO:0030246
GL_003157	Protein phosphatase 1 regulatory subunit 3A	Q16821	5ZQV	Homo sapiens (human)	9606	glycogen binding glycogen metabolic process membrane protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005977 GO:0005979 GO:0008157 GO:0016020 GO:2001069
GL_000195	C-type lectin domain family 6 member A	Q6EIG7	5VYB	Homo sapiens (human)	9606	adaptive immune response antifungal innate immune response calcium ion binding carbohydrate binding defense response to fungus detection of yeast external side of plasma membrane innate immune response mannose binding pattern recognition receptor activity phospholipase binding plasma membrane positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cytokine production positive regulation of intracellular signal transduction positive regulation of peptidyl-tyrosine phosphorylation response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001819 GO:0001878 GO:0001879 GO:0002223 GO:0002250 GO:0005509 GO:0005537 GO:0005886 GO:0009897 GO:0030246 GO:0038187 GO:0043123 GO:0043274 GO:0045087 GO:0050731 GO:0050832 GO:0061760 GO:1902533 GO:2000318
GL_001982	Asialoglycoprotein receptor 1	P07306	1DV8 5JPV 5JQ1 6YAU	Homo sapiens (human)	9606	asialoglycoprotein receptor activity cellular response to extracellular stimulus external side of plasma membrane extracellular region fucose binding identical protein binding mannose binding metal ion binding plasma membrane receptor-mediated endocytosis signaling receptor activity	GO:0004873 GO:0005537 GO:0005576 GO:0005886 GO:0006898 GO:0009897 GO:0031668 GO:0038023 GO:0042802 GO:0042806 GO:0046872
GL_000397	FRAS1-related extracellular matrix protein 1	Q5H8C1		Homo sapiens (human)	9606	anatomical structure morphogenesis basement membrane carbohydrate binding cell communication cell-matrix adhesion collagen-containing extracellular matrix craniofacial suture morphogenesis extracellular region membrane metal ion binding	GO:0005576 GO:0005604 GO:0007154 GO:0007160 GO:0009653 GO:0016020 GO:0030246 GO:0046872 GO:0062023 GO:0097094
GL_000519	Galectin-related protein	Q3ZCW2	2JJ6 3B9C	Homo sapiens (human)	9606	carbohydrate binding	GO:0030246
GL_002411	Paired immunoglobulin-like type 2 receptor alpha	Q9UKJ1	3WUZ 3WV0 4NFB 5XO2 5XOF	Homo sapiens (human)	9606	MHC class I protein binding extracellular exosome plasma membrane signal transduction	GO:0005886 GO:0007165 GO:0042288 GO:0070062
GL_000146	C-type lectin domain family 12 member B	Q2HXU8		Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane melanocyte proliferation natural killer cell inhibitory signaling pathway negative regulation of natural killer cell mediated cytotoxicity negative regulation of receptor signaling pathway via STAT negative regulation of signaling receptor activity protein phosphatase binding protein-containing complex signaling receptor inhibitor activity	GO:0002769 GO:0009897 GO:0019903 GO:0030246 GO:0030547 GO:0032991 GO:0045953 GO:0097325 GO:1904893 GO:2000272
GL_002018	Galectin-16	A8MUM7	6LJP 6LJQ 6LJR	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix lactose binding positive regulation of T cell apoptotic process	GO:0006915 GO:0030246 GO:0030395 GO:0062023 GO:0070234
GL_000320	Chondrolectin	Q9H9P2		Homo sapiens (human)	9606	carbohydrate binding centrosome cytoplasm cytosol endoplasmic reticulum membrane muscle organ development nervous system development perinuclear region of cytoplasm positive regulation of axonogenesis	GO:0005737 GO:0005789 GO:0005813 GO:0005829 GO:0007399 GO:0007517 GO:0030246 GO:0048471 GO:0050772
GL_001648	Hematopoietic progenitor cell antigen CD34	P28906		Homo sapiens (human)	9606	RNA polymerase II-specific DNA-binding transcription factor binding apical plasma membrane basal plasma membrane carbohydrate binding cell motility cell-cell adhesion cell-matrix adhesion cytoplasm endothelial cell proliferation endothelium development external side of plasma membrane extracellular exosome assembly extracellular region glomerular endothelium development glomerular endothelium fenestra glomerular filtration hematopoietic stem cell proliferation hemopoiesis intercellular bridge leukocyte migration lysosome mesangial cell-matrix adhesion metanephric glomerular mesangial cell differentiation negative regulation of gene expression negative regulation of interleukin-2 production paracrine signaling perinuclear region of cytoplasm plasma membrane positive regulation of angiogenesis positive regulation of gene expression positive regulation of granulocyte colony-stimulating factor production positive regulation of odontogenesis positive regulation of vasculogenesis signal transduction stem cell proliferation sulfate binding tissue homeostasis transdifferentiation vascular wound healing	GO:0001894 GO:0001935 GO:0003094 GO:0003158 GO:0005576 GO:0005737 GO:0005764 GO:0005886 GO:0007160 GO:0007165 GO:0009897 GO:0009925 GO:0010628 GO:0010629 GO:0016324 GO:0030097 GO:0030246 GO:0032703 GO:0035759 GO:0036053 GO:0038001 GO:0042482 GO:0043199 GO:0045171 GO:0045766 GO:0048471 GO:0048870 GO:0050900 GO:0060290 GO:0061042 GO:0061629 GO:0071425 GO:0071657 GO:0071971 GO:0072011 GO:0072089 GO:0072254 GO:0098609 GO:2001214
GL_001379	BOS complex subunit NOMO3	P69849		Homo sapiens (human)	9606	carbohydrate binding determination of left/right asymmetry in lateral mesoderm endoplasmic reticulum membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane negative regulation of nodal signaling pathway ribosome binding	GO:0003140 GO:0005789 GO:0030246 GO:0043022 GO:0160063 GO:0160064 GO:1900108
GL_005149	Prolyl 4-hydroxylase subunit alpha-2	O15460	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC	Homo sapiens (human)	9606	L-ascorbic acid binding cytosol electron transfer activity endoplasmic reticulum lumen endoplasmic reticulum intracellular membrane-bounded organelle iron ion binding nucleoplasm procollagen-proline 4-dioxygenase activity	GO:0004656 GO:0005506 GO:0005654 GO:0005783 GO:0005788 GO:0005829 GO:0009055 GO:0031418 GO:0043231
GL_000295	Calreticulin-3	Q96L12		Homo sapiens (human)	9606	ERAD pathway carbohydrate binding cell differentiation endoplasmic reticulum lumen endoplasmic reticulum membrane metal ion binding nuclear envelope protein folding chaperone protein folding spermatogenesis unfolded protein binding	GO:0005635 GO:0005788 GO:0005789 GO:0006457 GO:0007283 GO:0030154 GO:0030246 GO:0036503 GO:0044183 GO:0046872 GO:0051082
GL_000174	C-type lectin domain family 4 member A	Q9UMR7	5B1W 5B1X	Homo sapiens (human)	9606	CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding cell adhesion cell surface receptor signaling pathway external side of plasma membrane mannose binding negative regulation of cytokine production negative regulation of tumor necrosis factor production plasma membrane plasmacytoid dendritic cell antigen processing and presentation transmembrane signaling receptor activity	GO:0001818 GO:0002250 GO:0002470 GO:0004888 GO:0005509 GO:0005537 GO:0005886 GO:0007155 GO:0007166 GO:0009897 GO:0030246 GO:0032720 GO:0036037 GO:0042590 GO:0061760
GL_002471	Glucose-6-phosphate 1-dehydrogenase	P11413	1QKI 2BH9 2BHL 5UKW 6E07 6E08 6JYU 6VA0 6VA7 6VA8 6VA9 6VAQ 7SEH 7SEI 7SNF 7SNG 7SNH 7SNI 7TOE 7TOF 7UAG 7UAL 7UC2 7ZVD	Homo sapiens (human)	9606	NADP binding NADP metabolic process NADPH regeneration cellular response to oxidative stress centriolar satellite cholesterol biosynthetic process cytoplasm cytoplasmic side of plasma membrane cytosol erythrocyte maturation extracellular exosome glucose 6-phosphate metabolic process glucose binding glucose metabolic process glucose-6-phosphate dehydrogenase activity glutathione metabolic process identical protein binding intracellular membrane-bounded organelle lipid metabolic process membrane negative regulation of cell growth involved in cardiac muscle cell development negative regulation of protein glutathionylation negative regulation of reactive oxygen species metabolic process pentose biosynthetic process pentose-phosphate shunt, oxidative branch pentose-phosphate shunt positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel protein homodimerization activity regulation of neuron apoptotic process response to ethanol response to food response to iron(III) ion response to organic cyclic compound ribose phosphate biosynthetic process substantia nigra development	GO:0004345 GO:0005536 GO:0005737 GO:0005829 GO:0006006 GO:0006098 GO:0006629 GO:0006695 GO:0006739 GO:0006740 GO:0006749 GO:0009051 GO:0009898 GO:0010041 GO:0010734 GO:0014070 GO:0016020 GO:0019322 GO:0021762 GO:0032094 GO:0034451 GO:0034599 GO:0042802 GO:0042803 GO:0043231 GO:0043249 GO:0043523 GO:0045471 GO:0046390 GO:0050661 GO:0051156 GO:0061052 GO:0070062 GO:1904879 GO:2000378

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