GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **51 - 75** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_002018	Galectin-16	A8MUM7	6LJP 6LJQ 6LJR	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix lactose binding positive regulation of T cell apoptotic process	GO:0006915 GO:0030246 GO:0030395 GO:0062023 GO:0070234
GL_000320	Chondrolectin	Q9H9P2		Homo sapiens (human)	9606	carbohydrate binding centrosome cytoplasm cytosol endoplasmic reticulum membrane muscle organ development nervous system development perinuclear region of cytoplasm positive regulation of axonogenesis	GO:0005737 GO:0005789 GO:0005813 GO:0005829 GO:0007399 GO:0007517 GO:0030246 GO:0048471 GO:0050772
GL_001648	Hematopoietic progenitor cell antigen CD34	P28906		Homo sapiens (human)	9606	RNA polymerase II-specific DNA-binding transcription factor binding apical plasma membrane basal plasma membrane carbohydrate binding cell motility cell-cell adhesion cell-matrix adhesion cytoplasm endothelial cell proliferation endothelium development external side of plasma membrane extracellular exosome assembly extracellular region glomerular endothelium development glomerular endothelium fenestra glomerular filtration hematopoietic stem cell proliferation hemopoiesis intercellular bridge leukocyte migration lysosome mesangial cell-matrix adhesion metanephric glomerular mesangial cell differentiation negative regulation of gene expression negative regulation of interleukin-2 production paracrine signaling perinuclear region of cytoplasm plasma membrane positive regulation of angiogenesis positive regulation of gene expression positive regulation of granulocyte colony-stimulating factor production positive regulation of odontogenesis positive regulation of vasculogenesis signal transduction stem cell proliferation sulfate binding tissue homeostasis transdifferentiation vascular wound healing	GO:0001894 GO:0001935 GO:0003094 GO:0003158 GO:0005576 GO:0005737 GO:0005764 GO:0005886 GO:0007160 GO:0007165 GO:0009897 GO:0009925 GO:0010628 GO:0010629 GO:0016324 GO:0030097 GO:0030246 GO:0032703 GO:0035759 GO:0036053 GO:0038001 GO:0042482 GO:0043199 GO:0045171 GO:0045766 GO:0048471 GO:0048870 GO:0050900 GO:0060290 GO:0061042 GO:0061629 GO:0071425 GO:0071657 GO:0071971 GO:0072011 GO:0072089 GO:0072254 GO:0098609 GO:2001214
GL_001379	BOS complex subunit NOMO3	P69849		Homo sapiens (human)	9606	carbohydrate binding determination of left/right asymmetry in lateral mesoderm endoplasmic reticulum membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane negative regulation of nodal signaling pathway ribosome binding	GO:0003140 GO:0005789 GO:0030246 GO:0043022 GO:0160063 GO:0160064 GO:1900108
GL_005149	Prolyl 4-hydroxylase subunit alpha-2	O15460	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC	Homo sapiens (human)	9606	L-ascorbic acid binding cytosol electron transfer activity endoplasmic reticulum lumen endoplasmic reticulum intracellular membrane-bounded organelle iron ion binding nucleoplasm procollagen-proline 4-dioxygenase activity	GO:0004656 GO:0005506 GO:0005654 GO:0005783 GO:0005788 GO:0005829 GO:0009055 GO:0031418 GO:0043231
GL_000295	Calreticulin-3	Q96L12		Homo sapiens (human)	9606	ERAD pathway carbohydrate binding cell differentiation endoplasmic reticulum lumen endoplasmic reticulum membrane metal ion binding nuclear envelope protein folding chaperone protein folding spermatogenesis unfolded protein binding	GO:0005635 GO:0005788 GO:0005789 GO:0006457 GO:0007283 GO:0030154 GO:0030246 GO:0036503 GO:0044183 GO:0046872 GO:0051082
GL_000174	C-type lectin domain family 4 member A	Q9UMR7	5B1W 5B1X	Homo sapiens (human)	9606	CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding cell adhesion cell surface receptor signaling pathway external side of plasma membrane mannose binding negative regulation of cytokine production negative regulation of tumor necrosis factor production plasma membrane plasmacytoid dendritic cell antigen processing and presentation transmembrane signaling receptor activity	GO:0001818 GO:0002250 GO:0002470 GO:0004888 GO:0005509 GO:0005537 GO:0005886 GO:0007155 GO:0007166 GO:0009897 GO:0030246 GO:0032720 GO:0036037 GO:0042590 GO:0061760
GL_002471	Glucose-6-phosphate 1-dehydrogenase	P11413	1QKI 2BH9 2BHL 5UKW 6E07 6E08 6JYU 6VA0 6VA7 6VA8 6VA9 6VAQ 7SEH 7SEI 7SNF 7SNG 7SNH 7SNI 7TOE 7TOF 7UAG 7UAL 7UC2 7ZVD	Homo sapiens (human)	9606	NADP binding NADP metabolic process NADPH regeneration cellular response to oxidative stress centriolar satellite cholesterol biosynthetic process cytoplasm cytoplasmic side of plasma membrane cytosol erythrocyte maturation extracellular exosome glucose 6-phosphate metabolic process glucose binding glucose metabolic process glucose-6-phosphate dehydrogenase activity glutathione metabolic process identical protein binding intracellular membrane-bounded organelle lipid metabolic process membrane negative regulation of cell growth involved in cardiac muscle cell development negative regulation of protein glutathionylation negative regulation of reactive oxygen species metabolic process pentose biosynthetic process pentose-phosphate shunt, oxidative branch pentose-phosphate shunt positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel protein homodimerization activity regulation of neuron apoptotic process response to ethanol response to food response to iron(III) ion response to organic cyclic compound ribose phosphate biosynthetic process substantia nigra development	GO:0004345 GO:0005536 GO:0005737 GO:0005829 GO:0006006 GO:0006098 GO:0006629 GO:0006695 GO:0006739 GO:0006740 GO:0006749 GO:0009051 GO:0009898 GO:0010041 GO:0010734 GO:0014070 GO:0016020 GO:0019322 GO:0021762 GO:0032094 GO:0034451 GO:0034599 GO:0042802 GO:0042803 GO:0043231 GO:0043249 GO:0043523 GO:0045471 GO:0046390 GO:0050661 GO:0051156 GO:0061052 GO:0070062 GO:1904879 GO:2000378
GL_002665	UTP--glucose-1-phosphate uridylyltransferase	Q16851	3R2W 3R3I 4R7P	Homo sapiens (human)	9606	UDP-glucose metabolic process UTP brain development cytoplasm cytosol extracellular exosome glucose 1-phosphate metabolic process glucose binding glycogen biosynthetic process glycogen metabolic process identical protein binding metal ion binding nucleus pyrimidine ribonucleotide binding	GO:0003983 GO:0005536 GO:0005634 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0006011 GO:0007420 GO:0019255 GO:0032557 GO:0042802 GO:0046872 GO:0070062
GL_000802	Natural killer cells antigen CD94	Q13241	1B6E 3BDW 3CDG 3CII	Homo sapiens (human)	9606	HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding MHC class Ib protein binding, via antigen binding groove adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane natural killer cell mediated immunity negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0023030 GO:0030246 GO:0032814 GO:0043235 GO:0045953 GO:0045954 GO:0062082 GO:1990405
GL_000197	C-type lectin domain family 7 member A	Q9BXN2		Homo sapiens (human)	9606	(1->3)-beta-D-glucan binding MHC protein binding T cell activation antifungal innate immune response carbohydrate binding carbohydrate mediated signaling cell activation cell recognition cell surface cellular response to molecule of fungal origin cytoplasm defense response to protozoan detection of fungus detection of molecule of fungal origin detection of yeast identical protein binding inflammatory response membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 17 type immune response positive regulation of calcium-mediated signaling positive regulation of canonical NF-kappaB signal transduction positive regulation of cell maturation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cytokine production involved in inflammatory response positive regulation of dendritic cell cytokine production positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of killing of cells of another organism positive regulation of lymphocyte activation positive regulation of monocyte chemotactic protein-1 production positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis positive regulation of protein-containing complex assembly positive regulation of respiratory burst positive regulation of superoxide anion generation positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of wound healing regulation of calcineurin-NFAT signaling cascade regulation of canonical NF-kappaB signal transduction response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001775 GO:0001872 GO:0001878 GO:0001879 GO:0002223 GO:0002732 GO:0005737 GO:0005886 GO:0006910 GO:0006954 GO:0008037 GO:0008284 GO:0009756 GO:0009986 GO:0010628 GO:0016020 GO:0016046 GO:0030246 GO:0030335 GO:0031334 GO:0032491 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032743 GO:0032747 GO:0032755 GO:0032757 GO:0032760 GO:0032930 GO:0038187 GO:0042110 GO:0042287 GO:0042802 GO:0042832 GO:0043122 GO:0043123 GO:0043280 GO:0045429 GO:0046872 GO:0050766 GO:0050850 GO:0051091 GO:0051092 GO:0051251 GO:0051712 GO:0060267 GO:0061760 GO:0070884 GO:0071226 GO:0071639 GO:0090303 GO:1900017 GO:1903431 GO:2000318
GL_002066	Regenerating islet-derived protein 3-gamma	Q6UW15		Homo sapiens (human)	9606	MyD88-dependent toll-like receptor signaling pathway acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide collagen-containing extracellular matrix cytoplasm defense response to Gram-positive bacterium disruption of cell wall in another organism extracellular region extracellular space metal ion binding negative regulation of keratinocyte differentiation oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation positive regulation of keratinocyte proliferation positive regulation of wound healing response to peptide hormone signaling receptor activity	GO:0002755 GO:0005576 GO:0005615 GO:0005737 GO:0006953 GO:0008284 GO:0010838 GO:0038023 GO:0042834 GO:0043434 GO:0044278 GO:0045617 GO:0046872 GO:0050830 GO:0061844 GO:0062023 GO:0070492 GO:0090303
GL_001183	1,4-alpha-glucan-branching enzyme	Q04446	4BZY 5CLT 5CLW	Homo sapiens (human)	9606	1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) 1,4-alpha-glucan branching enzyme activity carbohydrate binding cation binding cytoplasm cytosol extracellular exosome generation of precursor metabolites and energy glycogen biosynthetic process glycogen metabolic process hydrolase activity, hydrolyzing O-glycosyl compounds negative regulation of neuron apoptotic process starch metabolic process	GO:0003844 GO:0004553 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0005982 GO:0006091 GO:0030246 GO:0043169 GO:0043524 GO:0070062 GO:0102752
GL_000972	Protein FAM3B	P58499		Homo sapiens (human)	9606	apoptotic process carbohydrate binding cytokine activity extracellular exosome extracellular region extracellular space insulin secretion	GO:0005125 GO:0005576 GO:0005615 GO:0006915 GO:0030073 GO:0030246 GO:0070062
GL_002384	CD83 antigen	Q01151	5MIX 5MJ0 5MJ1 5MJ2	Homo sapiens (human)	9606	CD4-positive, alpha-beta T cell differentiation defense response external side of plasma membrane humoral immune response negative regulation of interleukin-4 production plasma membrane positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of interleukin-10 production positive regulation of interleukin-2 production response to organic cyclic compound signal transduction	GO:0005886 GO:0006952 GO:0006959 GO:0007165 GO:0009897 GO:0014070 GO:0032713 GO:0032733 GO:0032743 GO:0043367 GO:0043372
GL_000151	C-type lectin domain family 2 member A	Q6UVW9	4IOP	Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane natural killer cell mediated cytotoxicity plasma membrane protein homodimerization activity	GO:0005886 GO:0009897 GO:0030246 GO:0042267 GO:0042803
GL_003151	Protein phosphatase 1 regulatory subunit 3F	Q6ZSY5		Homo sapiens (human)	9606	glycogen binding membrane protein phosphatase 1 binding protein phosphatase binding protein phosphatase type 1 complex regulation of glycogen (starch) synthase activity regulation of glycogen biosynthetic process	GO:0000164 GO:0005979 GO:0008157 GO:0016020 GO:0019903 GO:2000465 GO:2001069
GL_005016	Prolyl hydroxylase EGLN2	Q96KS0	5V1B	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cell redox homeostasis cellular response to hypoxia cytoplasm ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity intracellular estrogen receptor signaling pathway nucleoplasm nucleus oxygen sensor activity peptidyl-proline 4-dioxygenase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline positive regulation of protein catabolic process regulation of cell growth regulation of neuron apoptotic process response to hypoxia	GO:0001558 GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0008198 GO:0016706 GO:0018401 GO:0019826 GO:0030520 GO:0031418 GO:0031545 GO:0043523 GO:0045454 GO:0045732 GO:0071456 GO:0160082
GL_000150	C-type lectin domain family 19 member A	Q6UXS0		Homo sapiens (human)	9606	carbohydrate binding extracellular region signaling receptor activity	GO:0005576 GO:0030246 GO:0038023
GL_000817	NKG2-A/NKG2-B type II integral membrane protein	P26715	2RMX 2YU7 3BDW 3CDG 3CII	Homo sapiens (human)	9606	CD8-positive, gamma-delta intraepithelial T cell differentiation HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane inhibitory MHC class Ib receptor activity innate immune response natural killer cell inhibitory signaling pathway negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0002305 GO:0002769 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0045087 GO:0045953 GO:0045954 GO:0062080 GO:0062082
GL_001114	Sialic acid-binding Ig-like lectin 12	Q96PQ1		Homo sapiens (human)	9606	carbohydrate binding cell adhesion plasma membrane sialic acid binding	GO:0005886 GO:0007155 GO:0030246 GO:0033691
GL_005250	Prolyl hydroxylase EGLN3	Q9H6Z9		Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity DNA damage response L-ascorbic acid binding activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process cellular response to hypoxia cytoplasm cytosol ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity nucleoplasm nucleus peptidyl-proline 4-dioxygenase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline protein hydroxylation regulation of cell population proliferation regulation of neuron apoptotic process response to hypoxia	GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0006974 GO:0008198 GO:0016706 GO:0018126 GO:0018401 GO:0031418 GO:0031545 GO:0042127 GO:0043523 GO:0071456 GO:0160082
GL_001363	Beta-glucuronidase	P08236	1BHG 3HN3	Homo sapiens (human)	9606	azurophil granule lumen beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen glucuronoside catabolic process glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lysosomal lumen membrane protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005576 GO:0005615 GO:0005975 GO:0006027 GO:0016020 GO:0019391 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904813
GL_002596	Hexokinase-4	P35557	1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I 7T78 7T79	Homo sapiens (human)	9606	ATP binding NADP metabolic process calcium ion import canonical glycolysis carbohydrate phosphorylation cellular response to insulin stimulus cellular response to leptin stimulus cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose catabolic process glucose homeostasis glucose metabolic process glucose sensor activity glycolytic process intracellular glucose homeostasis mannokinase activity mitochondrion negative regulation of gluconeogenesis nucleoplasm positive regulation of glycogen biosynthetic process positive regulation of insulin secretion regulation of glycolytic process regulation of insulin secretion regulation of potassium ion transport response to glucose	GO:0001678 GO:0004340 GO:0005524 GO:0005536 GO:0005654 GO:0005739 GO:0005829 GO:0006006 GO:0006007 GO:0006096 GO:0006110 GO:0006739 GO:0008865 GO:0009749 GO:0019158 GO:0032024 GO:0032869 GO:0042593 GO:0043266 GO:0044320 GO:0045721 GO:0045725 GO:0046835 GO:0050796 GO:0051156 GO:0061621 GO:0070509 GO:0141089
GL_000908	Polypeptide N-acetylgalactosaminyltransferase 18	Q6P9A2		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0030246 GO:0046872

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