GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	March 3, 2025
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **51 - 75** of **297** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_000835	Oxidized low-density lipoprotein receptor 1	P78380	1YPO 1YPQ 1YPU 1YXJ 1YXK 3VLG 6TL7 6TL9 6TLA 7R8U 7W5D 7XMP	Homo sapiens (human)	9606	blood circulation carbohydrate binding extracellular region identical protein binding immune system process inflammatory response intracellular membrane-bounded organelle leukocyte cell-cell adhesion lipoprotein metabolic process low-density lipoprotein particle receptor activity membrane raft membrane nucleoplasm plasma membrane proteolysis receptor complex specific granule membrane tertiary granule membrane	GO:0002376 GO:0005041 GO:0005576 GO:0005654 GO:0005886 GO:0006508 GO:0006954 GO:0007159 GO:0008015 GO:0016020 GO:0030246 GO:0035579 GO:0042157 GO:0042802 GO:0043231 GO:0043235 GO:0045121 GO:0070821
GL_001728	Neutral alpha-glucosidase C	Q8TET4		Homo sapiens (human)	9606	N-glycan processing alpha-1,4-glucosidase activity carbohydrate binding carbohydrate metabolic process	GO:0004558 GO:0005975 GO:0006491 GO:0030246
GL_004978	Egl nine homolog 1	Q9GZT9	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4 6ZBN 6ZBO 7Q5V 7Q5X 7UJV 7UMP 8J1K 8Q5S 8Q64 8Q6D 8Q6E	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cardiac muscle tissue morphogenesis cellular response to hypoxia cytoplasm cytosol enzyme binding ferrous iron binding glutamatergic synapse heart trabecula formation hypoxia-inducible factor-proline dioxygenase activity intracellular iron ion homeostasis intracellular membrane-bounded organelle intracellular oxygen homeostasis labyrinthine layer development negative regulation of DNA-binding transcription factor activity negative regulation of cyclic-nucleotide phosphodiesterase activity nucleus peptidyl-proline 4-dioxygenase activity peptidyl-proline dioxygenase activity positive regulation of transcription by RNA polymerase II postsynaptic density regulation of angiogenesis regulation of modification of postsynaptic structure regulation protein catabolic process at postsynapse response to hypoxia response to nitric oxide ventricular septum morphogenesis	GO:0001666 GO:0005634 GO:0005737 GO:0005829 GO:0006879 GO:0008198 GO:0014069 GO:0016706 GO:0019899 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043231 GO:0043433 GO:0045765 GO:0045944 GO:0051344 GO:0055008 GO:0060347 GO:0060412 GO:0060711 GO:0071456 GO:0071731 GO:0098978 GO:0099159 GO:0140252 GO:0160082
GL_002347	Neural cell adhesion molecule 1	P13591	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	Homo sapiens (human)	9606	Golgi membrane cell adhesion cell surface collagen-containing extracellular matrix commissural neuron axon guidance cytosol epithelial to mesenchymal transition external side of plasma membrane extracellular region membrane plasma membrane regulation of semaphorin-plexin signaling pathway virus receptor activity	GO:0000139 GO:0001618 GO:0001837 GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0062023 GO:0071679 GO:2001260
GL_001761	Probable maltase-glucoamylase 2	Q2M2H8		Homo sapiens (human)	9606	alpha-1,4-glucosidase activity carbohydrate binding carbohydrate metabolic process glucan 1,4-alpha-glucosidase activity membrane	GO:0004339 GO:0004558 GO:0005975 GO:0016020 GO:0030246
GL_000551	Cell surface hyaluronidase CEMIP2	Q9UHN6	8C6I	Homo sapiens (human)	9606	angiogenesis cadherin binding calcium ion binding carbohydrate binding cytosol extracellular exosome hyaluronan catabolic process hyalurononglucosaminidase activity intracellular membrane-bounded organelle membrane nucleolus plasma membrane regulation of sprouting angiogenesis	GO:0001525 GO:0004415 GO:0005509 GO:0005730 GO:0005829 GO:0005886 GO:0016020 GO:0030214 GO:0030246 GO:0043231 GO:0045296 GO:0070062 GO:1903670
GL_000150	C-type lectin domain family 19 member A	Q6UXS0		Homo sapiens (human)	9606	carbohydrate binding extracellular region	GO:0005576 GO:0030246
GL_002017	Galectin-12	Q96DT0		Homo sapiens (human)	9606	cytoplasm intrinsic apoptotic signaling pathway lactose binding mitochondrion nucleus	GO:0005634 GO:0005737 GO:0005739 GO:0030395 GO:0097193
GL_001363	Beta-glucuronidase	P08236	1BHG 3HN3	Homo sapiens (human)	9606	azurophil granule lumen beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lysosomal lumen membrane protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005576 GO:0005615 GO:0005975 GO:0006027 GO:0016020 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904813
GL_000842	Pancreatic adenocarcinoma up-regulated factor	Q96DA0	3AQG	Homo sapiens (human)	9606	apicolateral plasma membrane carbohydrate binding cell migration cytoplasm extracellular exosome extracellular region extracellular space plasma membrane	GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0016327 GO:0016477 GO:0030246 GO:0070062
GL_002357	Myelin protein P0	P25189	3OAI 8IIA	Homo sapiens (human)	9606	cell aggregation cell-cell adhesion via plasma-membrane adhesion molecules chemical synaptic transmission myelin sheath myelination plasma membrane structural molecule activity synapse	GO:0005198 GO:0005886 GO:0007268 GO:0042552 GO:0043209 GO:0045202 GO:0098742 GO:0098743
GL_000075	Attractin-like protein 1	Q5VV63		Homo sapiens (human)	9606	G protein-coupled receptor signaling pathway Notch binding carbohydrate binding membrane	GO:0005112 GO:0007186 GO:0016020 GO:0030246
GL_000180	C-type lectin domain family 4 member E	Q9ULY5	3WH2 3WH3	Homo sapiens (human)	9606	Fc-gamma receptor signaling pathway T cell differentiation involved in immune response antifungal innate immune response calcium ion binding carbohydrate binding cell projection defense response to bacterium external side of plasma membrane glycolipid binding innate immune response membrane pattern recognition receptor activity pattern recognition receptor signaling pathway phagocytic cup phagocytic vesicle membrane plasma membrane positive regulation of cytokine production	GO:0001819 GO:0001891 GO:0002221 GO:0002292 GO:0005509 GO:0005886 GO:0009897 GO:0016020 GO:0030246 GO:0030670 GO:0038094 GO:0038187 GO:0042742 GO:0042995 GO:0045087 GO:0051861 GO:0061760
GL_001835	Sorbitol dehydrogenase	Q00796	1PL6 1PL7 1PL8	Homo sapiens (human)	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_003157	Protein phosphatase 1 regulatory subunit 3A	Q16821	5ZQV	Homo sapiens (human)	9606	glycogen binding glycogen metabolic process membrane protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005977 GO:0005979 GO:0008157 GO:0016020 GO:2001069
GL_005117	Transmembrane prolyl 4-hydroxylase	Q9NXG6	6TP5	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding calcium ion binding endoplasmic reticulum membrane endoplasmic reticulum hypoxia-inducible factor-proline dioxygenase activity iron ion binding procollagen-proline 4-dioxygenase activity regulation of erythrocyte differentiation	GO:0004656 GO:0005506 GO:0005509 GO:0005783 GO:0005789 GO:0016706 GO:0031418 GO:0045646 GO:0160082
GL_002763	Glycogen debranching enzyme	P35573		Homo sapiens (human)	9606	4-alpha-glucanotransferase activity amylo-alpha-1,6-glucosidase activity cytoplasm cytosol extracellular region ficolin-1-rich granule lumen glycogen biosynthetic process glycogen catabolic process glycogen debranching enzyme activity inclusion body isoamylase complex nucleus polysaccharide binding polyubiquitin modification-dependent protein binding response to glucocorticoid response to nutrient sarcoplasmic reticulum secretory granule lumen	GO:0004133 GO:0004134 GO:0004135 GO:0005576 GO:0005634 GO:0005737 GO:0005829 GO:0005978 GO:0005980 GO:0007584 GO:0016234 GO:0016529 GO:0030247 GO:0031593 GO:0034774 GO:0043033 GO:0051384 GO:1904813
GL_002042	Lithostathine-1-beta	P48304		Homo sapiens (human)	9606	antimicrobial humoral immune response mediated by antimicrobial peptide extracellular exosome extracellular space oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation response to peptide hormone signaling receptor activity	GO:0005615 GO:0008284 GO:0038023 GO:0042834 GO:0043434 GO:0061844 GO:0070062 GO:0070492
GL_003320	Fucose mutarotase	A2VDF0		Homo sapiens (human)	9606	L-fucose mutarotase activity cytosol fucose binding fucose metabolic process fucosylation racemase and epimerase activity, acting on carbohydrates and derivatives	GO:0005829 GO:0006004 GO:0016857 GO:0036065 GO:0036373 GO:0042806
GL_002388	Neuronal pentraxin-1	Q15818	6YPE	Homo sapiens (human)	9606	axonogenesis involved in innervation cellular response to glucose stimulus cellular response to potassium ion central nervous system development chemical synaptic transmission endoplasmic reticulum glutamatergic synapse metal ion binding mitochondrial fragmentation involved in apoptotic process mitochondrial transport neurotransmitter receptor localization to postsynaptic specialization membrane postsynaptic density assembly synaptic cleft transport vesicle	GO:0005783 GO:0006839 GO:0007268 GO:0007417 GO:0030133 GO:0035865 GO:0043083 GO:0043653 GO:0046872 GO:0060385 GO:0071333 GO:0097107 GO:0098978 GO:0099645
GL_001503	Galactose-3-O-sulfotransferase 3	Q96A11		Homo sapiens (human)	9606	3'-phosphoadenosine 5'-phosphosulfate binding Golgi cisterna membrane carbohydrate binding galactose 3-O-sulfotransferase activity galactosylceramide sulfotransferase activity glycolipid biosynthetic process membrane monosaccharide metabolic process oligosaccharide metabolic process poly-N-acetyllactosamine metabolic process proteoglycan biosynthetic process proteoglycan sulfotransferase activity sulfur compound metabolic process	GO:0001733 GO:0005996 GO:0006790 GO:0009247 GO:0009311 GO:0016020 GO:0030166 GO:0030246 GO:0030309 GO:0032580 GO:0050656 GO:0050694 GO:0050698
GL_001020	Pulmonary surfactant-associated protein A1	Q8IWL2		Homo sapiens (human)	9606	carbohydrate binding clathrin-coated endocytic vesicle collagen trimer endoplasmic reticulum membrane extracellular region extracellular space lamellar body lipid transporter activity multivesicular body opsonization respiratory gaseous exchange by respiratory system	GO:0005319 GO:0005576 GO:0005581 GO:0005615 GO:0005771 GO:0005789 GO:0007585 GO:0008228 GO:0030246 GO:0042599 GO:0045334
GL_001725	Neutral alpha-glucosidase AB	Q14697	8D43 8EMR	Homo sapiens (human)	9606	Glc2Man9GlcNAc2 oligosaccharide glucosidase activity Golgi apparatus N-glycan processing RNA binding alpha-glucosidase activity carbohydrate binding carbohydrate metabolic process endoplasmic reticulum lumen extracellular exosome glucan 1,3-alpha-glucosidase activity glucosidase II complex intracellular membrane-bounded organelle melanosome membrane	GO:0003723 GO:0005788 GO:0005794 GO:0005975 GO:0006491 GO:0016020 GO:0017177 GO:0030246 GO:0033919 GO:0042470 GO:0043231 GO:0070062 GO:0090599 GO:0106407
GL_000766	Low affinity immunoglobulin epsilon Fc receptor	P06734	1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M	Homo sapiens (human)	9606	B cell antigen processing and presentation Fc receptor-mediated immune complex endocytosis IgE binding carbohydrate binding external side of plasma membrane extracellular exosome immune response integrin binding low-affinity IgE receptor activity macrophage activation metal ion binding plasma membrane positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of killing of cells of another organism positive regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase biosynthetic process protease binding	GO:0002020 GO:0002450 GO:0002925 GO:0005178 GO:0005886 GO:0006955 GO:0009897 GO:0019769 GO:0019863 GO:0030246 GO:0042116 GO:0046872 GO:0051000 GO:0051712 GO:0051770 GO:0070062 GO:0160006
GL_002069	Regenerating islet-derived protein 4	Q9BYZ8	2KV3	Homo sapiens (human)	9606	cytoplasm extracellular region heparin binding mannan binding response to bacterium signaling receptor activity	GO:0005576 GO:0005737 GO:0008201 GO:0009617 GO:0038023 GO:2001065

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