GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **76 - 100** of **298** in total

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GlyCosmos Lectin ▼	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_002411	Paired immunoglobulin-like type 2 receptor alpha	Q9UKJ1	3WUZ 3WV0 4NFB 5XO2 5XOF	Homo sapiens (human)	9606		MHC class I protein binding extracellular exosome plasma membrane signal transduction	GO:0005886 GO:0007165 GO:0042288 GO:0070062
GL_002410	Paired immunoglobulin-like type 2 receptor beta	Q9UKJ0	4NFC 4NFD	Homo sapiens (human)	9606		MHC class I protein binding activation of transmembrane receptor protein tyrosine kinase activity plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway	GO:0005886 GO:0007169 GO:0007171 GO:0042288
GL_002405	Chitinase domain-containing protein 1	Q9BWS9	3BXW	Homo sapiens (human)	9606		carbohydrate metabolic process chitin binding endomembrane system extracellular exosome extracellular region extracellular space innate immune response late endosome lysosomal lumen lysosome membrane negative regulation of cytokine production involved in inflammatory response nucleus oligosaccharide binding trans-Golgi network	GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0005770 GO:0005802 GO:0005975 GO:0008061 GO:0012505 GO:0016020 GO:0043202 GO:0045087 GO:0070062 GO:0070492 GO:1900016
GL_002404	Collectin-11	Q9BWP8	4YLI 4YMD	Homo sapiens (human)	9606		DNA binding antimicrobial humoral response calcium ion binding calcium-dependent carbohydrate binding cell surface pattern recognition receptor signaling pathway collagen trimer complement activation, lectin pathway complement activation developmental process execution phase of apoptosis external side of plasma membrane extracellular region extracellular space fucose binding identical protein binding mannose binding oligosaccharide binding positive regulation of opsonization proteolysis serine-type endopeptidase complex	GO:0001867 GO:0002752 GO:0003677 GO:0005509 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0006956 GO:0009897 GO:0019730 GO:0032502 GO:0042802 GO:0042806 GO:0070492 GO:0097194 GO:0120153 GO:1903028 GO:1905370
GL_002402	Fibrinogen C domain-containing protein 1	Q8N539	4M7F 4M7H 6ZQR 6ZQX 6ZQY 6ZR0 6ZR3 6ZR4	Homo sapiens (human)	9606		chitin binding collagen-containing extracellular matrix extracellular space membrane metal ion binding	GO:0005615 GO:0008061 GO:0016020 GO:0046872 GO:0062023
GL_002388	Neuronal pentraxin-1	Q15818	6YPE	Homo sapiens (human)	9606		axonogenesis involved in innervation cellular response to glucose stimulus cellular response to potassium ion central nervous system development chemical synaptic transmission endoplasmic reticulum glutamatergic synapse metal ion binding mitochondrial fragmentation involved in apoptotic process mitochondrial transport neurotransmitter receptor localization to postsynaptic specialization membrane postsynaptic density assembly synaptic cleft transport vesicle	GO:0005783 GO:0006839 GO:0007268 GO:0007417 GO:0030133 GO:0035865 GO:0043083 GO:0043653 GO:0046872 GO:0060385 GO:0071333 GO:0097107 GO:0098978 GO:0099645
GL_002386	Trefoil factor 3	Q07654	1E9T 1PE3 6V1C	Homo sapiens (human)	9606		extracellular region extracellular space identical protein binding maintenance of gastrointestinal epithelium regulation of glucose metabolic process secretory granule	GO:0005576 GO:0005615 GO:0010906 GO:0030141 GO:0030277 GO:0042802
GL_002384	CD83 antigen	Q01151	5MIX 5MJ0 5MJ1 5MJ2	Homo sapiens (human)	9606		CD4-positive, alpha-beta T cell differentiation defense response external side of plasma membrane humoral immune response negative regulation of interleukin-4 production plasma membrane positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of interleukin-10 production positive regulation of interleukin-2 production response to organic cyclic compound signal transduction	GO:0005886 GO:0006952 GO:0006959 GO:0007165 GO:0009897 GO:0014070 GO:0032713 GO:0032733 GO:0032743 GO:0043367 GO:0043372
GL_002375	Coxsackievirus and adenovirus receptor	P78310	1EAJ 1F5W 1JEW 1KAC 1P69 1P6A 1RSF 2J12 2J1K 2NPL 2W9L 2WBW 3J6L 3J6M 3J6N 3J6O 7DPZ 7DQ1 7VXZ 7VYK 7VYL 7VYM 7W14	Homo sapiens (human)	9606		AV node cell to bundle of His cell communication AV node cell-bundle of His cell adhesion involved in cell communication PDZ domain binding acrosomal vesicle actin cytoskeleton organization adherens junction apicolateral plasma membrane basolateral plasma membrane beta-catenin binding bicellular tight junction cardiac muscle cell development cell adhesion molecule binding cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell body cell junction cell-cell junction organization cell-cell junction connexin binding cytoplasm defense response to virus epithelial structure maintenance extracellular region extracellular space filopodium gamma-delta T cell activation germ cell migration growth cone heart development heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homotypic cell-cell adhesion identical protein binding integrin binding intercalated disc membrane raft mitochondrion organization neuromuscular junction neuron projection neutrophil chemotaxis nucleoplasm plasma membrane protein-containing complex regulation of AV node cell action potential signaling receptor binding transepithelial transport virus receptor activity	GO:0001618 GO:0001669 GO:0005102 GO:0005178 GO:0005576 GO:0005615 GO:0005654 GO:0005737 GO:0005886 GO:0005911 GO:0005912 GO:0005923 GO:0007005 GO:0007157 GO:0007507 GO:0008013 GO:0008354 GO:0010669 GO:0014704 GO:0016323 GO:0016327 GO:0030036 GO:0030054 GO:0030165 GO:0030175 GO:0030426 GO:0030593 GO:0031594 GO:0032991 GO:0034109 GO:0042802 GO:0043005 GO:0044297 GO:0045121 GO:0045216 GO:0046629 GO:0050839 GO:0051607 GO:0055013 GO:0070633 GO:0071253 GO:0086067 GO:0086072 GO:0086082 GO:0098904
GL_002359	Pentraxin-related protein PTX3	P26022	7ZL1	Homo sapiens (human)	9606		(1->3)-beta-D-glucan binding complement component C1q complex binding extracellular matrix organization extracellular matrix extracellular region extracellular space identical protein binding inflammatory response innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation by host of viral process negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of viral entry into host cell opsonization ovarian cumulus expansion positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis response to yeast specific granule lumen tertiary granule lumen virion binding	GO:0001550 GO:0001849 GO:0001872 GO:0001878 GO:0005576 GO:0005615 GO:0006954 GO:0008228 GO:0030198 GO:0031012 GO:0035580 GO:0042802 GO:0044793 GO:0044869 GO:0044871 GO:0045087 GO:0045429 GO:0046597 GO:0046790 GO:0050766 GO:1903016 GO:1903019 GO:1904724
GL_002357	Myelin protein P0	P25189	3OAI 8IIA	Homo sapiens (human)	9606		cell aggregation cell-cell adhesion via plasma-membrane adhesion molecules chemical synaptic transmission myelin sheath myelination plasma membrane structural molecule activity synapse	GO:0005198 GO:0005886 GO:0007268 GO:0042552 GO:0043209 GO:0045202 GO:0098742 GO:0098743
GL_002356	Tenascin	P24821	1TEN 2RB8 2RBL 5R5T 5R5U 5R5V 5R5W 5R5X 5R5Y 5R5Z 5R60 5R61 5R62 5R63 6BRB 6QNV 8FN8 8FNB	Homo sapiens (human)	9606		basement membrane bud outgrowth involved in lung branching cell adhesion cellular response to prostaglandin D stimulus cellular response to retinoic acid cellular response to vitamin D collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix structural constituent extracellular region extracellular space focal adhesion integrin binding interstitial matrix membrane mesenchymal-epithelial cell signaling involved in prostate gland development morphogenesis of an epithelium negative regulation of cell adhesion neuromuscular junction development odontogenesis of dentin-containing tooth osteoblast differentiation peripheral nervous system axon regeneration perisynaptic extracellular matrix positive regulation of cell population proliferation positive regulation of gene expression prostate gland epithelium morphogenesis regulation of cell adhesion regulation of cell growth regulation of cell migration regulation of inflammatory response response to ethanol response to fibroblast growth factor response to mechanical stimulus response to wounding syndecan binding tenascin complex	GO:0001558 GO:0001649 GO:0002009 GO:0005178 GO:0005201 GO:0005576 GO:0005604 GO:0005614 GO:0005615 GO:0005788 GO:0005925 GO:0007155 GO:0007162 GO:0007528 GO:0008284 GO:0009611 GO:0009612 GO:0010628 GO:0014012 GO:0016020 GO:0030155 GO:0030334 GO:0042475 GO:0045471 GO:0045545 GO:0050727 GO:0060447 GO:0060739 GO:0060740 GO:0062023 GO:0071300 GO:0071305 GO:0071774 GO:0071799 GO:0090733 GO:0098966
GL_002347	Neural cell adhesion molecule 1	P13591	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	Homo sapiens (human)	9606		Golgi membrane cell adhesion cell surface collagen-containing extracellular matrix commissural neuron axon guidance cytosol epithelial to mesenchymal transition external side of plasma membrane extracellular region membrane plasma membrane regulation of semaphorin-plexin signaling pathway virus receptor activity	GO:0000139 GO:0001618 GO:0001837 GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0062023 GO:0071679 GO:2001260
GL_002343	Cation-independent mannose-6-phosphate receptor	P11717	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ	Homo sapiens (human)	9606		G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome membrane endosome enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network membrane trans-Golgi network transport vesicle trans-Golgi network transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
GL_002341	Mannose-binding protein C	P11226	1HUP	Homo sapiens (human)	9606	1641	acute-phase response antiviral innate immune response calcium-dependent protein binding cell surface pattern recognition receptor signaling pathway cell surface collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium defense response to bacterium external side of plasma membrane extracellular region extracellular space identical protein binding innate immune response killing by host of symbiont cells mannose binding multivesicular body negative regulation of viral process opsonization positive regulation of opsonization positive regulation of phagocytosis proteolysis response to oxidative stress serine-type endopeptidase complex signaling receptor binding surfactant homeostasis	GO:0001867 GO:0002752 GO:0005102 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0005771 GO:0006508 GO:0006953 GO:0006958 GO:0006979 GO:0008228 GO:0009897 GO:0009986 GO:0042742 GO:0042802 GO:0043129 GO:0045087 GO:0048306 GO:0048525 GO:0050766 GO:0050830 GO:0051873 GO:0140374 GO:1903028 GO:1905370
GL_002325	T-cell surface antigen CD2	P06729	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	Homo sapiens (human)	9606		Golgi apparatus T cell activation apoptotic process cell surface receptor signaling pathway cell surface cell-cell adhesion cell-cell junction cytoplasmic side of plasma membrane external side of plasma membrane extracellular region heterotypic cell-cell adhesion identical protein binding membrane raft polarization natural killer cell activation natural killer cell mediated cytotoxicity nucleoplasm plasma membrane positive regulation of interleukin-8 production positive regulation of myeloid dendritic cell activation positive regulation of tumor necrosis factor production positive regulation of type II interferon production protein self-association protein-containing complex receptor tyrosine kinase binding regulation of T cell differentiation signaling receptor activity signaling receptor binding	GO:0001766 GO:0005102 GO:0005576 GO:0005654 GO:0005794 GO:0005886 GO:0005911 GO:0006915 GO:0007166 GO:0009897 GO:0009898 GO:0009986 GO:0030101 GO:0030887 GO:0030971 GO:0032729 GO:0032757 GO:0032760 GO:0032991 GO:0034113 GO:0038023 GO:0042110 GO:0042267 GO:0042802 GO:0043621 GO:0045580 GO:0098609
GL_002323	Intercellular adhesion molecule 1	P05362	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	Homo sapiens (human)	9606		T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell antigen processing and presentation T cell extravasation adhesion of symbiont to host cell adhesion mediated by integrin cell adhesion cell surface cellular response to amyloid-beta cellular response to glucose stimulus cellular response to leukemia inhibitory factor collagen-containing extracellular matrix establishment of endothelial barrier external side of plasma membrane extracellular exosome extracellular space focal adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules immunological synapse integrin binding leukocyte cell-cell adhesion leukocyte migration membrane raft membrane to membrane docking membrane negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cellular extravasation receptor-mediated virion attachment to host cell regulation of leukocyte mediated cytotoxicity regulation of ruffle assembly signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0001772 GO:0001910 GO:0002291 GO:0002457 GO:0002693 GO:0004888 GO:0005178 GO:0005615 GO:0005886 GO:0005925 GO:0007155 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0016020 GO:0022614 GO:0033627 GO:0038023 GO:0044406 GO:0045121 GO:0046813 GO:0050900 GO:0061028 GO:0062023 GO:0070062 GO:0070374 GO:0071333 GO:0072683 GO:1900027 GO:1902042 GO:1904646 GO:1990830 GO:2000352
GL_002318	Trefoil factor 1	P04155	1HI7 1PS2 6V1D	Homo sapiens (human)	9606		carbohydrate metabolic process cell differentiation cell population proliferation extracellular region extracellular space growth factor activity maintenance of gastrointestinal epithelium negative regulation of cell population proliferation response to immobilization stress response to iron ion response to peptide hormone	GO:0005576 GO:0005615 GO:0005975 GO:0008083 GO:0008283 GO:0008285 GO:0010039 GO:0030154 GO:0030277 GO:0035902 GO:0043434
GL_002302	C-reactive protein	P02741	1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA	Homo sapiens (human)	9606		acute-phase response calcium ion binding choline binding complement component C1q complex binding defense response to Gram-positive bacterium extracellular region extracellular space identical protein binding inflammatory response innate immune response low-density lipoprotein particle binding low-density lipoprotein particle receptor binding negative regulation of lipid storage negative regulation of macrophage derived foam cell differentiation negative regulation of mononuclear cell proliferation opsonization positive regulation of gene expression positive regulation of superoxide anion generation regulation of interleukin-8 production vasoconstriction	GO:0001849 GO:0005509 GO:0005576 GO:0005615 GO:0006953 GO:0006954 GO:0008228 GO:0010628 GO:0010745 GO:0010888 GO:0030169 GO:0032677 GO:0032930 GO:0032945 GO:0033265 GO:0042310 GO:0042802 GO:0045087 GO:0050750 GO:0050830
GL_002299	Neural cell adhesion molecule 2	O15394	2DOC 2JLL 2KBG 2V5T 2VAJ 2WIM 2XY1 2XY2 2XYC	Homo sapiens (human)	9606		axon axonal fasciculation identical protein binding membrane neuron cell-cell adhesion nuclear body plasma membrane	GO:0005886 GO:0007158 GO:0007413 GO:0016020 GO:0016604 GO:0030424 GO:0042802
GL_002077	VIP36-like protein	Q9H0V9		Homo sapiens (human)	9606		COPII-coated ER to Golgi transport vesicle Golgi apparatus Golgi membrane endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment mannose binding membrane metal ion binding protein folding protein transport	GO:0000139 GO:0005537 GO:0005789 GO:0005793 GO:0005794 GO:0006457 GO:0006888 GO:0015031 GO:0016020 GO:0030134 GO:0046872
GL_002069	Regenerating islet-derived protein 4	Q9BYZ8	2KV3	Homo sapiens (human)	9606		cytoplasm extracellular region heparin binding mannan binding response to bacterium signaling receptor activity	GO:0005576 GO:0005737 GO:0008201 GO:0009617 GO:0038023 GO:2001065
GL_002066	Regenerating islet-derived protein 3-gamma	Q6UW15		Homo sapiens (human)	9606		MyD88-dependent toll-like receptor signaling pathway acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide collagen-containing extracellular matrix cytoplasm defense response to Gram-positive bacterium disruption of cell wall in another organism extracellular region extracellular space metal ion binding negative regulation of keratinocyte differentiation oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation positive regulation of keratinocyte proliferation positive regulation of wound healing response to peptide hormone signaling receptor activity	GO:0002755 GO:0005576 GO:0005615 GO:0005737 GO:0006953 GO:0008284 GO:0010838 GO:0038023 GO:0042834 GO:0043434 GO:0044278 GO:0045617 GO:0046872 GO:0050830 GO:0061844 GO:0062023 GO:0070492 GO:0090303
GL_002057	Protein ERGIC-53-like	Q9HAT1		Homo sapiens (human)	9606		COPII-coated ER to Golgi transport vesicle Golgi membrane collagen-containing extracellular matrix endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment mannose binding	GO:0000139 GO:0005537 GO:0005789 GO:0005793 GO:0006888 GO:0030134 GO:0033116 GO:0062023
GL_002053	Protein ERGIC-53	P49257	3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE	Homo sapiens (human)	9606		COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane Golgi membrane Golgi organization blood coagulation collagen-containing extracellular matrix endoplasmic reticulum membrane endoplasmic reticulum organization endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum extracellular exosome mannose binding membrane metal ion binding negative regulation of protein targeting to mitochondrion positive regulation of organelle organization protein folding protein transport sarcomere unfolded protein binding	GO:0000139 GO:0005537 GO:0005783 GO:0005789 GO:0005793 GO:0006457 GO:0006888 GO:0007029 GO:0007030 GO:0007596 GO:0010638 GO:0012507 GO:0015031 GO:0016020 GO:0030017 GO:0030134 GO:0033116 GO:0046872 GO:0051082 GO:0062023 GO:0070062 GO:1903215

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