GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **76 - 100** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_001029	Putative C-type lectin domain family 20 member A	Q6ZU45		Homo sapiens (human)	9606	carbohydrate binding	GO:0030246
GL_001123	Sialic acid-binding Ig-like lectin 9	Q9Y336		Homo sapiens (human)	9606	carbohydrate binding cell adhesion cell surface receptor signaling pathway plasma membrane secretory granule membrane sialic acid binding	GO:0005886 GO:0007155 GO:0007166 GO:0030246 GO:0030667 GO:0033691
GL_000927	Polypeptide N-acetylgalactosaminyltransferase 6	Q8NCL4		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via threonine protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0018243 GO:0030246 GO:0046872 GO:0048471
GL_000466	Galactoside-binding soluble lectin 13	Q9UHV8	5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix cytoplasm lysophospholipase activity nuclear body nuclear matrix nucleoplasm phospholipid metabolic process	GO:0004622 GO:0005654 GO:0005737 GO:0006644 GO:0006915 GO:0016363 GO:0016604 GO:0030246 GO:0062023
GL_001376	BOS complex subunit NOMO1	Q15155		Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane ribosome binding	GO:0005789 GO:0016020 GO:0030246 GO:0043022 GO:0160063 GO:0160064
GL_002402	Fibrinogen C domain-containing protein 1	Q8N539	4M7F 4M7H 6ZQR 6ZQX 6ZQY 6ZR0 6ZR3 6ZR4	Homo sapiens (human)	9606	chitin binding collagen-containing extracellular matrix extracellular space membrane metal ion binding	GO:0005615 GO:0008061 GO:0016020 GO:0046872 GO:0062023
GL_003161	Protein phosphatase 1 regulatory subunit 3D	O95685		Homo sapiens (human)	9606	glycogen binding glycogen granule glycogen metabolic process protein phosphatase 1 binding protein phosphatase type 1 complex protein serine/threonine phosphatase activity regulation of glycogen biosynthetic process regulation of glycogen catabolic process	GO:0000164 GO:0004722 GO:0005977 GO:0005979 GO:0005981 GO:0008157 GO:0042587 GO:2001069
GL_000967	Protein eva-1 homolog C	P58658		Homo sapiens (human)	9606	carbohydrate binding extracellular region heparin binding membrane	GO:0005576 GO:0008201 GO:0016020 GO:0030246
GL_002486	Hexokinase HKDC1	Q2TB90		Homo sapiens (human)	9606	ATP binding carbohydrate phosphorylation cytoplasm cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process intracellular glucose homeostasis mitochondrial membrane mitochondrion photoreceptor inner segment	GO:0001678 GO:0001917 GO:0004340 GO:0005524 GO:0005536 GO:0005737 GO:0005739 GO:0005829 GO:0006006 GO:0006096 GO:0008865 GO:0031966 GO:0046835 GO:0051156
GL_001459	Epididymis-specific alpha-mannosidase	Q9Y2E5		Homo sapiens (human)	9606	alpha-mannosidase activity carbohydrate binding extracellular exosome lysosomal lumen lysosome mannose metabolic process metal ion binding oligosaccharide catabolic process	GO:0004559 GO:0005764 GO:0006013 GO:0009313 GO:0030246 GO:0043202 GO:0046872 GO:0070062
GL_004920	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3	Q6PK18		Homo sapiens (human)	9606	L-ascorbic acid binding dioxygenase activity iron ion binding membrane oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0005506 GO:0016020 GO:0016705 GO:0031418 GO:0051213
GL_002323	Intercellular adhesion molecule 1	P05362	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	Homo sapiens (human)	9606	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell antigen processing and presentation T cell extravasation adhesion of symbiont to host cell adhesion mediated by integrin cell adhesion cell surface cellular response to amyloid-beta cellular response to glucose stimulus cellular response to leukemia inhibitory factor collagen-containing extracellular matrix establishment of endothelial barrier external side of plasma membrane extracellular exosome extracellular space focal adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules immunological synapse integrin binding leukocyte cell-cell adhesion leukocyte migration membrane raft membrane to membrane docking membrane negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cellular extravasation receptor-mediated virion attachment to host cell regulation of leukocyte mediated cytotoxicity regulation of ruffle assembly signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0001772 GO:0001910 GO:0002291 GO:0002457 GO:0002693 GO:0004888 GO:0005178 GO:0005615 GO:0005886 GO:0005925 GO:0007155 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0016020 GO:0022614 GO:0033627 GO:0038023 GO:0044406 GO:0045121 GO:0046813 GO:0050900 GO:0061028 GO:0062023 GO:0070062 GO:0070374 GO:0071333 GO:0072683 GO:1900027 GO:1902042 GO:1904646 GO:1990830 GO:2000352
GL_003320	Fucose mutarotase	A2VDF0		Homo sapiens (human)	9606	L-fucose mutarotase activity cytosol fucose binding fucose metabolic process fucosylation racemase and epimerase activity, acting on carbohydrates and derivatives	GO:0005829 GO:0006004 GO:0016857 GO:0036065 GO:0036373 GO:0042806
GL_002010	Ficolin-2	Q15485	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T	Homo sapiens (human)	9606	antigen binding blood microparticle calcium-dependent protein binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway defense response to Gram-negative bacterium defense response to Gram-positive bacterium external side of plasma membrane extracellular exosome extracellular region extracellular space mannan binding metal ion binding opsonization positive regulation of opsonization proteoglycan binding proteolysis recognition of apoptotic cell serine-type endopeptidase complex signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0008228 GO:0009897 GO:0043394 GO:0043654 GO:0046872 GO:0048306 GO:0050829 GO:0050830 GO:0062023 GO:0070062 GO:0072562 GO:0097367 GO:1903028 GO:1905370 GO:2001065
GL_000190	C-type lectin domain family 5 member A	Q9NY25	2YHF	Homo sapiens (human)	9606	carbohydrate binding cell surface cellular defense response cytosol innate immune response myeloid cell differentiation negative regulation of apoptotic process negative regulation of myeloid cell apoptotic process osteoblast development plasma membrane positive regulation of cytokine production signal transduction specific granule membrane tertiary granule membrane virus receptor activity	GO:0001618 GO:0001819 GO:0002076 GO:0005829 GO:0005886 GO:0006968 GO:0007165 GO:0009986 GO:0030099 GO:0030246 GO:0033033 GO:0035579 GO:0043066 GO:0045087 GO:0070821
GL_004621	Collectin-10	Q9Y6Z7		Homo sapiens (human)	9606	Golgi apparatus cell surface pattern recognition receptor signaling pathway chemoattractant activity collagen trimer complement activation, lectin pathway cranial skeletal system development cytoplasm external side of plasma membrane extracellular region extracellular space mannose binding multivesicular body positive regulation of opsonization proteolysis serine-type endopeptidase complex	GO:0001867 GO:0002752 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0005737 GO:0005771 GO:0005794 GO:0006508 GO:0009897 GO:0042056 GO:1903028 GO:1904888 GO:1905370
GL_000931	Polypeptide N-acetylgalactosaminyltransferase 9	Q9HCQ5		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_002347	Neural cell adhesion molecule 1	P13591	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	Homo sapiens (human)	9606	Golgi membrane cell adhesion cell surface collagen-containing extracellular matrix commissural neuron axon guidance cytosol epithelial to mesenchymal transition external side of plasma membrane extracellular region membrane plasma membrane regulation of semaphorin-plexin signaling pathway virus receptor activity	GO:0000139 GO:0001618 GO:0001837 GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0062023 GO:0071679 GO:2001260
GL_001477	F-box only protein 6	Q9NRD1		Homo sapiens (human)	9606	DNA damage checkpoint signaling DNA repair ERAD pathway SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process carbohydrate binding cytoplasm cytosol endoplasmic reticulum quality control compartment glycoprotein catabolic process protein ubiquitination proteolysis response to unfolded protein ubiquitin protein ligase activity	GO:0000077 GO:0005737 GO:0005829 GO:0006281 GO:0006508 GO:0006516 GO:0006986 GO:0016567 GO:0019005 GO:0030246 GO:0031146 GO:0036503 GO:0044322 GO:0061630
GL_000895	Polypeptide N-acetylgalactosaminyltransferase 12	Q8IXK2	6PXU	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_000077	B-cell differentiation antigen CD72	P21854		Homo sapiens (human)	9606	carbohydrate binding cell adhesion plasma membrane signaling receptor binding transmembrane signaling receptor activity	GO:0004888 GO:0005102 GO:0005886 GO:0007155 GO:0030246
GL_001993	C-type lectin domain family 18 member C	Q8NCF0		Homo sapiens (human)	9606	Golgi apparatus endoplasmic reticulum endosome extracellular space polysaccharide binding	GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0030247
GL_000239	C-type mannose receptor 2	Q9UBG0	5AO5 5AO6 5E4K 5E4L 5EW6	Homo sapiens (human)	9606	carbohydrate binding collagen binding collagen catabolic process endocytosis focal adhesion membrane osteoblast differentiation signaling receptor activity	GO:0001649 GO:0005518 GO:0005925 GO:0006897 GO:0016020 GO:0030246 GO:0030574 GO:0038023
GL_002428	Sialic acid-binding Ig-like lectin 15	Q6ZMC9	7ZOZ	Homo sapiens (human)	9606	plasma membrane protein-containing complex regulation of actin cytoskeleton organization regulation of bone resorption regulation of osteoclast development	GO:0005886 GO:0032956 GO:0032991 GO:0045124 GO:2001204
GL_000152	C-type lectin domain family 2 member B	Q92478		Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane identical protein binding plasma membrane	GO:0005886 GO:0009897 GO:0030246 GO:0042802

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