GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **76 - 100** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_000466	Galactoside-binding soluble lectin 13	Q9UHV8	5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix cytoplasm lysophospholipase activity nuclear body nuclear matrix nucleoplasm phospholipid metabolic process	GO:0004622 GO:0005654 GO:0005737 GO:0006644 GO:0006915 GO:0016363 GO:0016604 GO:0030246 GO:0062023
GL_001376	BOS complex subunit NOMO1	Q15155		Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane ribosome binding	GO:0005789 GO:0016020 GO:0030246 GO:0043022 GO:0160063 GO:0160064
GL_002402	Fibrinogen C domain-containing protein 1	Q8N539	4M7F 4M7H 6ZQR 6ZQX 6ZQY 6ZR0 6ZR3 6ZR4	Homo sapiens (human)	9606	chitin binding collagen-containing extracellular matrix extracellular space membrane metal ion binding	GO:0005615 GO:0008061 GO:0016020 GO:0046872 GO:0062023
GL_003161	Protein phosphatase 1 regulatory subunit 3D	O95685		Homo sapiens (human)	9606	glycogen binding glycogen granule glycogen metabolic process protein phosphatase 1 binding protein phosphatase type 1 complex protein serine/threonine phosphatase activity regulation of glycogen biosynthetic process regulation of glycogen catabolic process	GO:0000164 GO:0004722 GO:0005977 GO:0005979 GO:0005981 GO:0008157 GO:0042587 GO:2001069
GL_000967	Protein eva-1 homolog C	P58658		Homo sapiens (human)	9606	carbohydrate binding extracellular region heparin binding membrane	GO:0005576 GO:0008201 GO:0016020 GO:0030246
GL_002486	Hexokinase HKDC1	Q2TB90		Homo sapiens (human)	9606	ATP binding carbohydrate phosphorylation cytoplasm cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process intracellular glucose homeostasis mitochondrial membrane mitochondrion photoreceptor inner segment	GO:0001678 GO:0001917 GO:0004340 GO:0005524 GO:0005536 GO:0005737 GO:0005739 GO:0005829 GO:0006006 GO:0006096 GO:0008865 GO:0031966 GO:0046835 GO:0051156
GL_001459	Epididymis-specific alpha-mannosidase	Q9Y2E5		Homo sapiens (human)	9606	alpha-mannosidase activity carbohydrate binding extracellular exosome lysosomal lumen lysosome mannose metabolic process metal ion binding oligosaccharide catabolic process	GO:0004559 GO:0005764 GO:0006013 GO:0009313 GO:0030246 GO:0043202 GO:0046872 GO:0070062
GL_004920	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3	Q6PK18		Homo sapiens (human)	9606	L-ascorbic acid binding dioxygenase activity iron ion binding membrane oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0005506 GO:0016020 GO:0016705 GO:0031418 GO:0051213
GL_002323	Intercellular adhesion molecule 1	P05362	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	Homo sapiens (human)	9606	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell antigen processing and presentation T cell extravasation adhesion of symbiont to host cell adhesion mediated by integrin cell adhesion cell surface cellular response to amyloid-beta cellular response to glucose stimulus cellular response to leukemia inhibitory factor collagen-containing extracellular matrix establishment of endothelial barrier external side of plasma membrane extracellular exosome extracellular space focal adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules immunological synapse integrin binding leukocyte cell-cell adhesion leukocyte migration membrane raft membrane to membrane docking membrane negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cellular extravasation receptor-mediated virion attachment to host cell regulation of leukocyte mediated cytotoxicity regulation of ruffle assembly signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0001772 GO:0001910 GO:0002291 GO:0002457 GO:0002693 GO:0004888 GO:0005178 GO:0005615 GO:0005886 GO:0005925 GO:0007155 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0016020 GO:0022614 GO:0033627 GO:0038023 GO:0044406 GO:0045121 GO:0046813 GO:0050900 GO:0061028 GO:0062023 GO:0070062 GO:0070374 GO:0071333 GO:0072683 GO:1900027 GO:1902042 GO:1904646 GO:1990830 GO:2000352
GL_003320	Fucose mutarotase	A2VDF0		Homo sapiens (human)	9606	L-fucose mutarotase activity cytosol fucose binding fucose metabolic process fucosylation racemase and epimerase activity, acting on carbohydrates and derivatives	GO:0005829 GO:0006004 GO:0016857 GO:0036065 GO:0036373 GO:0042806
GL_002010	Ficolin-2	Q15485	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T	Homo sapiens (human)	9606	antigen binding blood microparticle calcium-dependent protein binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway defense response to Gram-negative bacterium defense response to Gram-positive bacterium external side of plasma membrane extracellular exosome extracellular region extracellular space mannan binding metal ion binding opsonization positive regulation of opsonization proteoglycan binding proteolysis recognition of apoptotic cell serine-type endopeptidase complex signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0008228 GO:0009897 GO:0043394 GO:0043654 GO:0046872 GO:0048306 GO:0050829 GO:0050830 GO:0062023 GO:0070062 GO:0072562 GO:0097367 GO:1903028 GO:1905370 GO:2001065
GL_000190	C-type lectin domain family 5 member A	Q9NY25	2YHF	Homo sapiens (human)	9606	carbohydrate binding cell surface cellular defense response cytosol innate immune response myeloid cell differentiation negative regulation of apoptotic process negative regulation of myeloid cell apoptotic process osteoblast development plasma membrane positive regulation of cytokine production signal transduction specific granule membrane tertiary granule membrane virus receptor activity	GO:0001618 GO:0001819 GO:0002076 GO:0005829 GO:0005886 GO:0006968 GO:0007165 GO:0009986 GO:0030099 GO:0030246 GO:0033033 GO:0035579 GO:0043066 GO:0045087 GO:0070821
GL_004621	Collectin-10	Q9Y6Z7		Homo sapiens (human)	9606	Golgi apparatus cell surface pattern recognition receptor signaling pathway chemoattractant activity collagen trimer complement activation, lectin pathway cranial skeletal system development cytoplasm external side of plasma membrane extracellular region extracellular space mannose binding multivesicular body positive regulation of opsonization proteolysis serine-type endopeptidase complex	GO:0001867 GO:0002752 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0005737 GO:0005771 GO:0005794 GO:0006508 GO:0009897 GO:0042056 GO:1903028 GO:1904888 GO:1905370
GL_000931	Polypeptide N-acetylgalactosaminyltransferase 9	Q9HCQ5		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_002347	Neural cell adhesion molecule 1	P13591	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	Homo sapiens (human)	9606	Golgi membrane cell adhesion cell surface collagen-containing extracellular matrix commissural neuron axon guidance cytosol epithelial to mesenchymal transition external side of plasma membrane extracellular region membrane plasma membrane regulation of semaphorin-plexin signaling pathway virus receptor activity	GO:0000139 GO:0001618 GO:0001837 GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0062023 GO:0071679 GO:2001260
GL_001477	F-box only protein 6	Q9NRD1		Homo sapiens (human)	9606	DNA damage checkpoint signaling DNA repair ERAD pathway SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process carbohydrate binding cytoplasm cytosol endoplasmic reticulum quality control compartment glycoprotein catabolic process protein ubiquitination proteolysis response to unfolded protein ubiquitin protein ligase activity	GO:0000077 GO:0005737 GO:0005829 GO:0006281 GO:0006508 GO:0006516 GO:0006986 GO:0016567 GO:0019005 GO:0030246 GO:0031146 GO:0036503 GO:0044322 GO:0061630
GL_000895	Polypeptide N-acetylgalactosaminyltransferase 12	Q8IXK2	6PXU	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_000077	B-cell differentiation antigen CD72	P21854		Homo sapiens (human)	9606	carbohydrate binding cell adhesion plasma membrane signaling receptor binding transmembrane signaling receptor activity	GO:0004888 GO:0005102 GO:0005886 GO:0007155 GO:0030246
GL_001993	C-type lectin domain family 18 member C	Q8NCF0		Homo sapiens (human)	9606	Golgi apparatus endoplasmic reticulum endosome extracellular space polysaccharide binding	GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0030247
GL_000239	C-type mannose receptor 2	Q9UBG0	5AO5 5AO6 5E4K 5E4L 5EW6	Homo sapiens (human)	9606	carbohydrate binding collagen binding collagen catabolic process endocytosis focal adhesion membrane osteoblast differentiation signaling receptor activity	GO:0001649 GO:0005518 GO:0005925 GO:0006897 GO:0016020 GO:0030246 GO:0030574 GO:0038023
GL_002428	Sialic acid-binding Ig-like lectin 15	Q6ZMC9	7ZOZ	Homo sapiens (human)	9606	plasma membrane protein-containing complex regulation of actin cytoskeleton organization regulation of bone resorption regulation of osteoclast development	GO:0005886 GO:0032956 GO:0032991 GO:0045124 GO:2001204
GL_000152	C-type lectin domain family 2 member B	Q92478		Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane identical protein binding plasma membrane	GO:0005886 GO:0009897 GO:0030246 GO:0042802
GL_002832	HLA class II histocompatibility antigen, DR alpha chain	P01903	1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4H1L 4H25 4H26 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 5V4M 5V4N 6ATF 6ATI 6ATZ 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A 7N19 7NZE 7O00 7YX9 7YXB 7Z0Q 8CMB 8CMC 8CMD 8CME 8CMF 8CMG 8CMH 8CMI 8EUQ 8TBP	Homo sapiens (human)	9606	ER to Golgi transport vesicle membrane Golgi membrane MHC class II protein complex binding MHC class II protein complex MHC class II receptor activity T cell receptor binding adaptive immune response antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II autolysosome membrane cell surface clathrin-coated endocytic vesicle membrane cognition early endosome membrane endocytic vesicle membrane extracellular exosome immune response immunological synapse late endosome membrane lumenal side of endoplasmic reticulum membrane lysosomal membrane lysosome myeloid dendritic cell antigen processing and presentation peptide antigen assembly with MHC class II protein complex peptide antigen binding plasma membrane polysaccharide binding positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity positive regulation of immune response positive regulation of memory T cell differentiation regulation of T-helper cell differentiation trans-Golgi network membrane transport vesicle membrane	GO:0000139 GO:0001772 GO:0001916 GO:0002250 GO:0002469 GO:0002491 GO:0002503 GO:0002504 GO:0005764 GO:0005765 GO:0005886 GO:0006955 GO:0009986 GO:0012507 GO:0019886 GO:0023026 GO:0030247 GO:0030658 GO:0030666 GO:0030669 GO:0031901 GO:0031902 GO:0032395 GO:0032588 GO:0032831 GO:0042605 GO:0042608 GO:0042613 GO:0043382 GO:0045622 GO:0050778 GO:0050870 GO:0050890 GO:0070062 GO:0098553 GO:0120281 GO:2000516
GL_002835	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	P22413	2YS0 6WET 6WEU 6WEV 6WEW 6WFJ 8GHR	Homo sapiens (human)	9606	3',5'-cyclic-AMP phosphodiesterase activity 3'-phosphoadenosine 5'-phosphosulfate binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process ATP binding ATP diphosphatase activity ATP metabolic process GTP diphosphatase activity UTP diphosphatase activity basolateral plasma membrane bone mineralization calcium ion binding cell surface cellular response to insulin stimulus cyclic-GMP-AMP hydrolase activity dinucleotide phosphatase activity exonuclease activity extracellular space gene expression generation of precursor metabolites and energy immune response inorganic diphosphate transport insulin receptor binding intracellular phosphate ion homeostasis lysosomal membrane melanocyte differentiation membrane negative regulation of bone mineralization negative regulation of cell growth negative regulation of fat cell differentiation negative regulation of glucose import negative regulation of glycogen biosynthetic process negative regulation of hh target transcription factor activity negative regulation of insulin receptor signaling pathway negative regulation of protein autophosphorylation nucleic acid binding nucleic acid metabolic process nucleoside triphosphate catabolic process nucleoside triphosphate diphosphatase activity phosphatase activity phosphate ion homeostasis phosphate-containing compound metabolic process phosphodiesterase I activity plasma membrane polysaccharide binding protein homodimerization activity regulation of bone mineralization response to ATP response to inorganic substance scavenger receptor activity sequestering of triglyceride zinc ion binding	GO:0003676 GO:0004115 GO:0004527 GO:0004528 GO:0004551 GO:0005044 GO:0005158 GO:0005509 GO:0005524 GO:0005615 GO:0005765 GO:0005886 GO:0006091 GO:0006796 GO:0006955 GO:0008270 GO:0009143 GO:0009986 GO:0010035 GO:0010467 GO:0016020 GO:0016323 GO:0016791 GO:0030247 GO:0030282 GO:0030308 GO:0030318 GO:0030500 GO:0030502 GO:0030505 GO:0030643 GO:0030730 GO:0031953 GO:0032869 GO:0033198 GO:0036219 GO:0036221 GO:0042803 GO:0045599 GO:0045719 GO:0046034 GO:0046325 GO:0046627 GO:0047429 GO:0047693 GO:0050427 GO:0050656 GO:0055062 GO:0090304 GO:0106177 GO:1990787
GL_001238	Alpha-mannosidase 2x	P49641		Homo sapiens (human)	9606	Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding hydrolase activity, hydrolyzing N-glycosyl compounds mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004559 GO:0004572 GO:0006013 GO:0006486 GO:0006491 GO:0016799 GO:0030246 GO:0046872

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