GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **76 - 100** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs ▲	LfDB IDs	Organism	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_000820	NKG2-C type II integral membrane protein	P26717	2L35		Homo sapiens (human)	9606		MHC class I protein complex binding activating MHC class Ib receptor activity adaptive immune response carbohydrate binding cellular defense response external side of plasma membrane natural killer cell mediated immunity plasma membrane positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation signal transduction stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0006968 GO:0007165 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0043323 GO:0045954 GO:0062081 GO:1990405
GL_000639	L-selectin	P14151	2LGF 3CFW 5VC1		Homo sapiens (human)	9606		calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding cell adhesion external side of plasma membrane extracellular space glycosphingolipid binding heparin binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte tethering or rolling oligosaccharide binding plasma membrane protease binding response to cytokine secretory granule membrane sialic acid binding	GO:0002020 GO:0005509 GO:0005615 GO:0005886 GO:0007155 GO:0007157 GO:0007159 GO:0008201 GO:0009897 GO:0016339 GO:0030246 GO:0030667 GO:0033691 GO:0034097 GO:0043208 GO:0050901 GO:0070492
GL_000178	C-type lectin domain family 4 member D	Q8WXI8	2LS8 3WHD		Homo sapiens (human)	9606		Fc-gamma receptor signaling pathway T cell differentiation involved in immune response adaptive immune response antifungal innate immune response carbohydrate binding defense response to bacterium external side of plasma membrane ficolin-1-rich granule membrane immunoglobulin receptor binding mannose binding metal ion binding pattern recognition receptor activity plasma membrane positive regulation of canonical NF-kappaB signal transduction positive regulation of myeloid dendritic cell activation specific granule membrane tertiary granule membrane	GO:0002250 GO:0002292 GO:0005537 GO:0005886 GO:0009897 GO:0030246 GO:0030887 GO:0034987 GO:0035579 GO:0038094 GO:0038187 GO:0042742 GO:0043123 GO:0046872 GO:0061760 GO:0070821 GO:0101003
GL_001741	Pleiotrophin	P21246	2N6F		Homo sapiens (human)	9606		Schaffer collateral - CA1 synapse bone mineralization carbohydrate binding chondroitin sulfate binding decidualization dendrite arborization dendrite regeneration endoplasmic reticulum estrous cycle extracellular region extracellular space growth factor activity heparin binding integrin binding integrin-mediated signaling pathway learning leukocyte chemotaxis involved in inflammatory response memory molecular function activator activity negative regulation of long-term synaptic potentiation negative regulation of neuroblast proliferation nervous system development oogenesis ossification involved in bone remodeling plasma membrane positive regulation of axon regeneration positive regulation of bone mineralization positive regulation of cell division positive regulation of cell population proliferation positive regulation of dendrite development positive regulation of hepatocyte proliferation positive regulation of leukocyte chemotaxis positive regulation of neuron projection development positive regulation of oligodendrocyte differentiation positive regulation of ossification positive regulation of stem cell differentiation protein kinase binding protein phosphatase inhibitor activity protein-containing complex receptor clustering regulation of endothelial cell migration regulation of hemopoiesis regulation of myelination regulation of stem cell population maintenance regulation of synaptic plasticity response to auditory stimulus tissue regeneration transmembrane receptor protein tyrosine phosphatase signaling pathway	GO:0002232 GO:0002690 GO:0004864 GO:0005178 GO:0005576 GO:0005615 GO:0005783 GO:0005886 GO:0007185 GO:0007229 GO:0007399 GO:0007406 GO:0007612 GO:0007613 GO:0008083 GO:0008201 GO:0008284 GO:0010594 GO:0010976 GO:0010996 GO:0019901 GO:0030246 GO:0030282 GO:0030501 GO:0031104 GO:0031641 GO:0032991 GO:0035374 GO:0042246 GO:0043113 GO:0043932 GO:0044849 GO:0045778 GO:0046697 GO:0048167 GO:0048477 GO:0048680 GO:0048714 GO:0051781 GO:0098685 GO:0140059 GO:0140677 GO:1900006 GO:1900272 GO:1903706 GO:2000036 GO:2000347 GO:2000738
GL_001122	Sialic acid-binding Ig-like lectin 8	Q9NYZ4	2N7A 2N7B 7QU6 7QUH 7QUI		Homo sapiens (human)	9606		carbohydrate binding cell adhesion membrane plasma membrane sialic acid binding signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007155 GO:0007165 GO:0016020 GO:0030246 GO:0033691
GL_000299	CD302 antigen	Q8IX05	2NAN		Homo sapiens (human)	9606		carbohydrate binding cell cortex external side of plasma membrane filopodium membrane microvillus phagocytosis signaling receptor activity	GO:0005902 GO:0005938 GO:0006909 GO:0009897 GO:0016020 GO:0030175 GO:0030246 GO:0038023
GL_002600	Hexokinase-2	P52789	2NZT 5HEX 5HFU 5HG1		Homo sapiens (human)	9606		ATP binding apoptotic mitochondrial changes canonical glycolysis carbohydrate phosphorylation cellular response to leukemia inhibitory factor centrosome cytosol establishment of protein localization to mitochondrion fructokinase activity fructose 6-phosphate metabolic process glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process hexokinase activity intracellular glucose homeostasis intracellular membrane-bounded organelle lactation maintenance of protein location in mitochondrion membrane mitochondrial outer membrane mitochondrion negative regulation of mitochondrial membrane permeability negative regulation of reactive oxygen species metabolic process positive regulation of angiogenesis positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization regulation of glucose import response to hypoxia response to ischemia sarcoplasmic reticulum	GO:0001666 GO:0001678 GO:0002931 GO:0004340 GO:0004396 GO:0005524 GO:0005536 GO:0005739 GO:0005741 GO:0005813 GO:0005829 GO:0006002 GO:0006006 GO:0006096 GO:0007595 GO:0008637 GO:0008865 GO:0016020 GO:0016529 GO:0035795 GO:0043231 GO:0045766 GO:0046324 GO:0046835 GO:0051156 GO:0061621 GO:0072655 GO:0072656 GO:1904925 GO:1990830 GO:2000378
GL_001998	Collectin-12	Q5KU26	2OX8		Homo sapiens (human)	9606		carbohydrate mediated signaling cellular response to exogenous dsRNA collagen trimer collagen-containing extracellular matrix defense response to bacterium defense response endocytic vesicle membrane extracellular space galactose binding innate immune response low-density lipoprotein particle binding membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane raft organization plasma membrane scavenger receptor activity toll-like receptor 3 signaling pathway	GO:0005044 GO:0005534 GO:0005581 GO:0005615 GO:0005886 GO:0006910 GO:0006952 GO:0009756 GO:0016020 GO:0030169 GO:0030666 GO:0034138 GO:0038187 GO:0042742 GO:0044857 GO:0045087 GO:0046872 GO:0062023 GO:0071360
GL_001708	Maltase-glucoamylase	O43451	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP		Homo sapiens (human)	9606		alpha-1,4-glucosidase activity amylase activity apical plasma membrane carbohydrate binding catalytic activity dextrin catabolic process extracellular exosome ficolin-1-rich granule membrane glucan 1,4-alpha-glucosidase activity maltose alpha-glucosidase activity maltose catabolic process plasma membrane starch catabolic process tertiary granule membrane	GO:0000025 GO:0003824 GO:0004339 GO:0004558 GO:0005886 GO:0005983 GO:0016160 GO:0016324 GO:0030246 GO:0032450 GO:0070062 GO:0070821 GO:0101003 GO:1901027
GL_000817	NKG2-A/NKG2-B type II integral membrane protein	P26715	2RMX 2YU7 3BDW 3CDG 3CII		Homo sapiens (human)	9606		CD8-positive, gamma-delta intraepithelial T cell differentiation HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane inhibitory MHC class Ib receptor activity innate immune response natural killer cell inhibitory signaling pathway negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0002305 GO:0002769 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0045087 GO:0045953 GO:0045954 GO:0062080 GO:0062082
GL_001410	Collagen alpha-1(IX) chain	P20849	2UUR 5CTD 5CTI 5CVA 5CVB		Homo sapiens (human)	9606		animal organ morphogenesis carbohydrate binding collagen type IX trimer collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix organization extracellular matrix structural constituent conferring tensile strength extracellular region extracellular space metal ion binding protein homodimerization activity	GO:0005576 GO:0005594 GO:0005615 GO:0005788 GO:0009887 GO:0030020 GO:0030198 GO:0030246 GO:0042803 GO:0046872 GO:0062023
GL_003353	Pyruvate kinase PKLR	P30613	2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCG 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 6NN4 6NN5 6NN7 6NN8 7FRV 7FRW 7FRX 7FRY 7FRZ 7FS0 7FS1 7FS2 7FS3 7FS4 7FS5 7FS6 7FS7 7FS8 7FS9 7FSA 7FSB 7FSC 7FSD 7QDN 7QZU 8TBS 8TBT 8TBU		Homo sapiens (human)	9606		ATP binding cellular response to epinephrine stimulus cellular response to insulin stimulus cytoplasm cytosol extracellular exosome glycolytic process kinase activity magnesium ion binding monosaccharide binding phosphorylation potassium ion binding pyruvate biosynthetic process pyruvate kinase activity pyruvate kinase complex response to ATP response to cAMP response to glucose response to hypoxia response to metal ion response to nutrient	GO:0000287 GO:0001666 GO:0004743 GO:0005524 GO:0005737 GO:0005829 GO:0006096 GO:0007584 GO:0009749 GO:0010038 GO:0016301 GO:0016310 GO:0030955 GO:0032869 GO:0033198 GO:0042866 GO:0048029 GO:0051591 GO:0070062 GO:0071872 GO:1902912
GL_000190	C-type lectin domain family 5 member A	Q9NY25	2YHF		Homo sapiens (human)	9606		carbohydrate binding cell surface cellular defense response cytosol innate immune response myeloid cell differentiation negative regulation of apoptotic process negative regulation of myeloid cell apoptotic process osteoblast development plasma membrane positive regulation of cytokine production signal transduction specific granule membrane tertiary granule membrane virus receptor activity	GO:0001618 GO:0001819 GO:0002076 GO:0005829 GO:0005886 GO:0006968 GO:0007165 GO:0009986 GO:0030099 GO:0030246 GO:0033033 GO:0035579 GO:0043066 GO:0045087 GO:0070821
GL_000509	Galectin-8 Aliases: Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8HL9	LfDB0273	Homo sapiens (human)	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_002835	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	P22413	2YS0 6WET 6WEU 6WEV 6WEW 6WFJ 8GHR		Homo sapiens (human)	9606		3',5'-cyclic-AMP phosphodiesterase activity 3'-phosphoadenosine 5'-phosphosulfate binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process ATP binding ATP diphosphatase activity ATP metabolic process GTP diphosphatase activity UTP diphosphatase activity basolateral plasma membrane bone mineralization calcium ion binding cell surface cellular response to insulin stimulus cyclic-GMP-AMP hydrolase activity dinucleotide phosphatase activity exonuclease activity extracellular space gene expression generation of precursor metabolites and energy immune response inorganic diphosphate transport insulin receptor binding intracellular phosphate ion homeostasis lysosomal membrane melanocyte differentiation membrane negative regulation of bone mineralization negative regulation of cell growth negative regulation of fat cell differentiation negative regulation of glucose import negative regulation of glycogen biosynthetic process negative regulation of hh target transcription factor activity negative regulation of insulin receptor signaling pathway negative regulation of protein autophosphorylation nucleic acid binding nucleic acid metabolic process nucleoside triphosphate catabolic process nucleoside triphosphate diphosphatase activity phosphatase activity phosphate ion homeostasis phosphate-containing compound metabolic process phosphodiesterase I activity plasma membrane polysaccharide binding protein homodimerization activity regulation of bone mineralization response to ATP response to inorganic substance scavenger receptor activity sequestering of triglyceride zinc ion binding	GO:0003676 GO:0004115 GO:0004527 GO:0004528 GO:0004551 GO:0005044 GO:0005158 GO:0005509 GO:0005524 GO:0005615 GO:0005765 GO:0005886 GO:0006091 GO:0006796 GO:0006955 GO:0008270 GO:0009143 GO:0009986 GO:0010035 GO:0010467 GO:0016020 GO:0016323 GO:0016791 GO:0030247 GO:0030282 GO:0030308 GO:0030318 GO:0030500 GO:0030502 GO:0030505 GO:0030643 GO:0030730 GO:0031953 GO:0032869 GO:0033198 GO:0036219 GO:0036221 GO:0042803 GO:0045599 GO:0045719 GO:0046034 GO:0046325 GO:0046627 GO:0047429 GO:0047693 GO:0050427 GO:0050656 GO:0055062 GO:0090304 GO:0106177 GO:1990787
GL_003205	Glycerophosphocholine phosphodiesterase GPCPD1	Q9NPB8	2Z0B		Homo sapiens (human)	9606		cytosol glycerophosphocholine phosphodiesterase activity glycerophospholipid catabolic process skeletal muscle tissue development starch binding	GO:0005829 GO:0007519 GO:0046475 GO:0047389 GO:2001070
GL_001119	Sialic acid-binding Ig-like lectin 5	O15389	2ZG1 2ZG2 2ZG3		Homo sapiens (human)	9606		carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane secretory granule membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0030667 GO:0033691 GO:0070821 GO:0101003
GL_002053	Protein ERGIC-53	P49257	3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE		Homo sapiens (human)	9606		COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane Golgi membrane Golgi organization blood coagulation collagen-containing extracellular matrix endoplasmic reticulum membrane endoplasmic reticulum organization endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum extracellular exosome mannose binding membrane metal ion binding negative regulation of protein targeting to mitochondrion positive regulation of organelle organization protein folding protein transport sarcomere unfolded protein binding	GO:0000139 GO:0005537 GO:0005783 GO:0005789 GO:0005793 GO:0006457 GO:0006888 GO:0007029 GO:0007030 GO:0007596 GO:0010638 GO:0012507 GO:0015031 GO:0016020 GO:0030017 GO:0030134 GO:0033116 GO:0046872 GO:0051082 GO:0062023 GO:0070062 GO:1903215
GL_000990	Protein OS-9	Q13438	3AIH		Homo sapiens (human)	9606		ERAD pathway Hrd1p ubiquitin ligase complex carbohydrate binding endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response endoplasmic reticulum negative regulation of retrograde protein transport, ER to cytosol protease binding protein retention in ER lumen protein targeting protein ubiquitination response to endoplasmic reticulum stress retrograde protein transport, ER to cytosol ubiquitin-dependent protein catabolic process	GO:0000836 GO:0002020 GO:0005783 GO:0005788 GO:0005789 GO:0006511 GO:0006605 GO:0006621 GO:0016567 GO:0030246 GO:0030968 GO:0030970 GO:0034976 GO:0036503 GO:1904153
GL_001720	Nectin-1	Q15223	3ALP 3SKU 3U82 3U83 4FMF 4MYW		Homo sapiens (human)	9606		adherens junction apical junction complex axon guidance carbohydrate binding cell adhesion molecule binding cell adhesion cell-cell adhesion cell-cell contact zone coreceptor activity dendrite desmosome organization enamel mineralization extracellular region growth cone membrane heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules hippocampal mossy fiber to CA3 synapse homophilic cell adhesion via plasma membrane adhesion molecules identical protein binding immune response iron ion transport lens morphogenesis in camera-type eye membrane plasma membrane presynaptic active zone membrane protein homodimerization activity protein localization to cell junction protein-containing complex binding regulation of synapse assembly retina development in camera-type eye viral entry into host cell virion binding virus receptor activity	GO:0001618 GO:0002089 GO:0002934 GO:0005576 GO:0005886 GO:0005912 GO:0006826 GO:0006955 GO:0007155 GO:0007156 GO:0007157 GO:0007411 GO:0015026 GO:0016020 GO:0030246 GO:0030425 GO:0032584 GO:0042802 GO:0042803 GO:0043296 GO:0044291 GO:0044877 GO:0046718 GO:0046790 GO:0048787 GO:0050839 GO:0051963 GO:0060041 GO:0070166 GO:0098609 GO:0098686 GO:1902414
GL_001178	Zymogen granule membrane protein 16	O60844	3APA 3VY6 3VY7 3VZE 3VZF 3VZG 7O3I 7O4P 7O88		Homo sapiens (human)	9606		Golgi lumen carbohydrate binding collagen-containing extracellular matrix defense response to Gram-positive bacterium extracellular space mucus layer peptidoglycan binding protein transport suppression of symbiont entry into host zymogen granule membrane	GO:0005615 GO:0005796 GO:0015031 GO:0030246 GO:0042589 GO:0042834 GO:0050830 GO:0052373 GO:0062023 GO:0070701
GL_000842	Pancreatic adenocarcinoma up-regulated factor	Q96DA0	3AQG		Homo sapiens (human)	9606		apicolateral plasma membrane carbohydrate binding cell migration cytoplasm extracellular exosome extracellular region extracellular space plasma membrane	GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0016327 GO:0016477 GO:0030246 GO:0070062
GL_004606	Basigin	P35613	3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8		Homo sapiens (human)	9606		Golgi membrane acrosomal membrane angiogenesis axon guidance axon basolateral plasma membrane cadherin binding cell surface receptor signaling pathway cell-cell adhesion mediator activity decidualization dendrite self-avoidance embryo implantation endoplasmic reticulum membrane endosome endothelial tube morphogenesis extracellular exosome focal adhesion homophilic cell adhesion via plasma membrane adhesion molecules intracellular membrane-bounded organelle mannose binding melanosome membrane mitochondrion neural retina development neutrophil chemotaxis odontogenesis of dentin-containing tooth photoreceptor cell maintenance photoreceptor inner segment photoreceptor outer segment plasma membrane positive regulation of endothelial cell migration positive regulation of interleukin-6 production positive regulation of matrix metallopeptidase secretion positive regulation of vascular endothelial growth factor production positive regulation of viral entry into host cell protein localization to plasma membrane response to cAMP response to mercury ion response to peptide hormone sarcolemma signaling receptor activity virus receptor activity	GO:0000139 GO:0001525 GO:0001618 GO:0001750 GO:0001917 GO:0002080 GO:0003407 GO:0005537 GO:0005739 GO:0005768 GO:0005789 GO:0005886 GO:0005925 GO:0007156 GO:0007166 GO:0007411 GO:0007566 GO:0010575 GO:0010595 GO:0016020 GO:0016323 GO:0030424 GO:0030593 GO:0032755 GO:0038023 GO:0042383 GO:0042470 GO:0042475 GO:0043231 GO:0043434 GO:0045296 GO:0045494 GO:0046598 GO:0046689 GO:0046697 GO:0051591 GO:0061154 GO:0070062 GO:0070593 GO:0072659 GO:0098632 GO:1904466
GL_002405	Chitinase domain-containing protein 1	Q9BWS9	3BXW		Homo sapiens (human)	9606		carbohydrate metabolic process chitin binding endomembrane system extracellular exosome extracellular region extracellular space innate immune response late endosome lysosomal lumen lysosome membrane negative regulation of cytokine production involved in inflammatory response nucleus oligosaccharide binding trans-Golgi network	GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0005770 GO:0005802 GO:0005975 GO:0008061 GO:0012505 GO:0016020 GO:0043202 GO:0045087 GO:0070062 GO:0070492 GO:1900016
GL_000189	C-type lectin domain family 4 member K	Q9UJ71	3C22 3KQG 3P5D 3P5E 3P5F 3P5G 3P5H 3P5I 3P7F 3P7G 3P7H 4AK8 4N32 4N33 4N34 4N35 4N36 4N37 4N38 5G6U 7WZ8 7YTQ		Homo sapiens (human)	9606	1842 5090	carbohydrate binding clathrin-coated endocytic vesicle membrane defense response to virus early endosome membrane endocytic vesicle external side of plasma membrane mannose binding plasma membrane signaling receptor activity	GO:0005537 GO:0005886 GO:0009897 GO:0030139 GO:0030246 GO:0030669 GO:0031901 GO:0038023 GO:0051607

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