GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **101 - 125** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism ▲	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_000820	NKG2-C type II integral membrane protein	P26717	2L35	Homo sapiens (human)	9606	MHC class I protein complex binding activating MHC class Ib receptor activity adaptive immune response carbohydrate binding cellular defense response external side of plasma membrane natural killer cell mediated immunity plasma membrane positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation signal transduction stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0006968 GO:0007165 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0043323 GO:0045954 GO:0062081 GO:1990405
GL_000482	Galectin-10	Q05315	1G86 1HDK 1LCL 1QKQ 5XRG 5XRH 5XRI 5XRJ 5XRK 5XRL 5XRM 5XRN 5XRO 5XRP 5YT4 6A1S 6A1T 6A1U 6A1V 6A1X 6A1Y 6GKQ 6GKS 6GKT 6GKU 6GLW 6GLX 6L64 6L67 6L68 6L6A 6L6B 6L6C 6L6D 6QRN	Homo sapiens (human)	9606	T cell apoptotic process carbohydrate binding collagen-containing extracellular matrix cysteine-type endopeptidase activity involved in apoptotic process cytosol identical protein binding regulation of T cell anergy regulation of T cell cytokine production regulation of activated T cell proliferation	GO:0002667 GO:0002724 GO:0005829 GO:0030246 GO:0042802 GO:0046006 GO:0062023 GO:0070231 GO:0097153
GL_001127	Sialoadhesin	Q9BZZ2		Homo sapiens (human)	9606	carbohydrate binding cell-cell adhesion cell-matrix adhesion clathrin-dependent endocytosis of virus by host cell early endosome extracellular region inflammatory response late endosome membrane negative regulation of type I interferon production plasma membrane virion binding	GO:0005576 GO:0005769 GO:0005770 GO:0005886 GO:0006954 GO:0007160 GO:0016020 GO:0030246 GO:0032480 GO:0046790 GO:0075512 GO:0098609
GL_001021	Pulmonary surfactant-associated protein A2	Q8IWL1		Homo sapiens (human)	9606	carbohydrate binding clathrin-coated endocytic vesicle collagen trimer endoplasmic reticulum membrane extracellular region extracellular space lamellar body multivesicular body respiratory gaseous exchange by respiratory system	GO:0005576 GO:0005581 GO:0005615 GO:0005771 GO:0005789 GO:0007585 GO:0030246 GO:0042599 GO:0045334
GL_004522	Fructose-bisphosphate aldolase B	P05062	1QO5 1XDL 1XDM 8D44	Homo sapiens (human)	9606	ATPase binding NADH oxidation centriolar satellite cytoskeletal protein binding cytosol extracellular exosome fructose 1,6-bisphosphate metabolic process fructose binding fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate fructose metabolic process fructose-1-phosphate aldolase activity fructose-bisphosphate aldolase activity gluconeogenesis glycolytic process identical protein binding microtubule organizing center molecular adaptor activity negative regulation of pentose-phosphate shunt positive regulation of ATP-dependent activity vacuolar proton-transporting V-type ATPase complex assembly	GO:0004332 GO:0005815 GO:0005829 GO:0006000 GO:0006094 GO:0006096 GO:0006116 GO:0008092 GO:0030388 GO:0032781 GO:0034451 GO:0042802 GO:0051117 GO:0060090 GO:0061609 GO:0061624 GO:0070061 GO:0070062 GO:0070072 GO:1905856
GL_002803	Uridylate-specific endoribonuclease	P21128		Homo sapiens (human)	9606	RNA binding RNA endonuclease activity cytoplasm extracellular region extracellular space female pregnancy growth factor activity immune response lyase activity manganese ion binding negative regulation of lipid catabolic process plasma membrane polysaccharide binding post-transcriptional gene silencing proteolysis scavenger receptor activity serine-type peptidase activity	GO:0003723 GO:0004521 GO:0005044 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0006508 GO:0006955 GO:0007565 GO:0008083 GO:0008236 GO:0016441 GO:0016829 GO:0030145 GO:0030247 GO:0050995
GL_001101	Serum amyloid P-component	P02743	1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	Homo sapiens (human)	9606	acute-phase response blood microparticle calcium ion binding carbohydrate binding chaperone-mediated protein complex assembly collagen-containing extracellular matrix complement component C1q complex binding extracellular exosome extracellular region extracellular space identical protein binding innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation of acute inflammatory response negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of monocyte differentiation negative regulation of viral entry into host cell negative regulation of viral process negative regulation of wound healing nucleus protein folding unfolded protein binding virion binding	GO:0001849 GO:0002674 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0006457 GO:0006953 GO:0030246 GO:0042802 GO:0044869 GO:0044871 GO:0045087 GO:0045656 GO:0046597 GO:0046790 GO:0048525 GO:0051082 GO:0051131 GO:0061045 GO:0062023 GO:0070062 GO:0072562 GO:1903016 GO:1903019
GL_000353	Doublecortin domain-containing protein 1	M0R2J8		Homo sapiens (human)	9606	Flemming body carbohydrate binding cell cycle cell division cytoplasm intracellular signal transduction microtubule binding microtubule midbody mitotic spindle regulation of mitotic cytokinesis	GO:0005737 GO:0005874 GO:0007049 GO:0008017 GO:0030246 GO:0030496 GO:0035556 GO:0051301 GO:0072686 GO:0090543 GO:1902412
GL_001708	Maltase-glucoamylase	O43451	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP	Homo sapiens (human)	9606	alpha-1,4-glucosidase activity amylase activity apical plasma membrane carbohydrate binding catalytic activity dextrin catabolic process extracellular exosome ficolin-1-rich granule membrane glucan 1,4-alpha-glucosidase activity maltose alpha-glucosidase activity maltose catabolic process plasma membrane starch catabolic process tertiary granule membrane	GO:0000025 GO:0003824 GO:0004339 GO:0004558 GO:0005886 GO:0005983 GO:0016160 GO:0016324 GO:0030246 GO:0032450 GO:0070062 GO:0070821 GO:0101003 GO:1901027
GL_002357	Myelin protein P0	P25189	3OAI 8IIA	Homo sapiens (human)	9606	cell aggregation cell-cell adhesion via plasma-membrane adhesion molecules chemical synaptic transmission myelin sheath myelination plasma membrane structural molecule activity synapse	GO:0005198 GO:0005886 GO:0007268 GO:0042552 GO:0043209 GO:0045202 GO:0098742 GO:0098743
GL_005069	Phytanoyl-CoA dioxygenase, peroxisomal	O14832	2A1X	Homo sapiens (human)	9606	2-oxobutyrate catabolic process 2-oxoglutarate metabolic process 9+0 non-motile cilium L-ascorbic acid binding carboxylic acid binding cytosol fatty acid alpha-oxidation ferrous iron binding isoprenoid metabolic process methyl-branched fatty acid metabolic process peroxisomal matrix peroxisome phytanoyl-CoA dioxygenase activity	GO:0001561 GO:0005777 GO:0005782 GO:0005829 GO:0006103 GO:0006720 GO:0008198 GO:0019606 GO:0031406 GO:0031418 GO:0048244 GO:0097089 GO:0097731
GL_001725	Neutral alpha-glucosidase AB	Q14697	8D43 8EMR	Homo sapiens (human)	9606	Golgi apparatus N-glycan processing RNA binding alpha-glucosidase activity carbohydrate binding carbohydrate metabolic process endoplasmic reticulum lumen extracellular exosome glucan 1,3-alpha-glucosidase activity glucosidase II complex intracellular membrane-bounded organelle melanosome membrane	GO:0003723 GO:0005788 GO:0005794 GO:0005975 GO:0006491 GO:0016020 GO:0017177 GO:0030246 GO:0033919 GO:0042470 GO:0043231 GO:0070062 GO:0090599
GL_001415	Contactin-1	Q12860	2EE2 3S97	Homo sapiens (human)	9606	Notch signaling pathway axon guidance axon brain development carbohydrate binding cell adhesion cell-cell adhesion mediator activity cell-cell adhesion central nervous system myelin formation cerebellum development extracellular exosome gene expression locomotory behavior membrane plasma membrane positive regulation of gene expression positive regulation of neuron projection development positive regulation of sodium ion transport postsynaptic membrane presynaptic membrane side of membrane	GO:0005886 GO:0007155 GO:0007219 GO:0007411 GO:0007420 GO:0007626 GO:0010467 GO:0010628 GO:0010765 GO:0010976 GO:0016020 GO:0021549 GO:0030246 GO:0030424 GO:0032289 GO:0042734 GO:0045211 GO:0070062 GO:0098552 GO:0098609 GO:0098632
GL_002853	Vitronectin	P04004	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9	Homo sapiens (human)	9606	Golgi lumen alphav-beta3 integrin-vitronectin complex basement membrane blood microparticle cell adhesion mediated by integrin cell adhesion cell migration cell-matrix adhesion collagen binding collagen-containing extracellular matrix endodermal cell differentiation endoplasmic reticulum extracellular exosome extracellular matrix binding extracellular matrix organization extracellular matrix structural constituent extracellular region extracellular space heparin binding identical protein binding immune response integrin binding intracellular membrane-bounded organelle liver regeneration negative regulation of blood coagulation negative regulation of endopeptidase activity negative regulation of fibrinolysis oligodendrocyte differentiation peptidase inhibitor complex polysaccharide binding positive regulation of cell-substrate adhesion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein binding positive regulation of receptor-mediated endocytosis positive regulation of smooth muscle cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of wound healing protein complex involved in cell-matrix adhesion protein polymerization regulation of cell adhesion rough endoplasmic reticulum lumen scavenger receptor activity smooth muscle cell-matrix adhesion	GO:0005044 GO:0005178 GO:0005201 GO:0005518 GO:0005576 GO:0005604 GO:0005615 GO:0005783 GO:0005796 GO:0006955 GO:0007155 GO:0007160 GO:0008201 GO:0010811 GO:0010951 GO:0014911 GO:0016477 GO:0030155 GO:0030195 GO:0030198 GO:0030247 GO:0030949 GO:0032092 GO:0033627 GO:0035987 GO:0042802 GO:0043231 GO:0048237 GO:0048260 GO:0048709 GO:0050731 GO:0050840 GO:0051258 GO:0051918 GO:0061302 GO:0062023 GO:0070062 GO:0071062 GO:0072562 GO:0090303 GO:0097421 GO:0098637 GO:1904090
GL_000985	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	Q8WZA1	5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC	Homo sapiens (human)	9606	Golgi membrane O-glycan processing acetylglucosaminyltransferase activity basement membrane organization beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity carbohydrate binding dentate gyrus development gene expression localization of cell manganese ion binding membrane myelination protein O-linked glycosylation protein O-linked mannosylation reactive gliosis sensory perception of sound	GO:0000139 GO:0006493 GO:0007605 GO:0008375 GO:0010467 GO:0016020 GO:0016266 GO:0021542 GO:0030145 GO:0030246 GO:0035269 GO:0042552 GO:0047223 GO:0051674 GO:0071711 GO:0150103
GL_001503	Galactose-3-O-sulfotransferase 3	Q96A11		Homo sapiens (human)	9606	3'-phosphoadenosine 5'-phosphosulfate binding Golgi cisterna membrane carbohydrate binding galactose 3-O-sulfotransferase activity galactosylceramide sulfotransferase activity glycolipid biosynthetic process membrane monosaccharide metabolic process oligosaccharide metabolic process poly-N-acetyllactosamine metabolic process proteoglycan biosynthetic process proteoglycan sulfotransferase activity sulfur compound metabolic process	GO:0001733 GO:0005996 GO:0006790 GO:0009247 GO:0009311 GO:0016020 GO:0030166 GO:0030246 GO:0030309 GO:0032580 GO:0050656 GO:0050694 GO:0050698
GL_000106	Bone marrow proteoglycan	P13727	1H8U 2BRS 4QXX 7Y5N 8HGG	Homo sapiens (human)	9606	carbohydrate binding collagen-containing extracellular matrix defense response to bacterium defense response to nematode extracellular exosome extracellular matrix structural constituent conferring compression resistance extracellular region ficolin-1-rich granule lumen heparin binding immune response negative regulation of interleukin-10 production negative regulation of macrophage cytokine production positive regulation of interleukin-4 production transport vesicle	GO:0002215 GO:0005576 GO:0006955 GO:0008201 GO:0010936 GO:0030021 GO:0030133 GO:0030246 GO:0032693 GO:0032753 GO:0042742 GO:0062023 GO:0070062 GO:1904813
GL_001122	Sialic acid-binding Ig-like lectin 8	Q9NYZ4	2N7A 2N7B 7QU6 7QUH 7QUI	Homo sapiens (human)	9606	carbohydrate binding cell adhesion membrane plasma membrane sialic acid binding signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007155 GO:0007165 GO:0016020 GO:0030246 GO:0033691
GL_000957	Probable polypeptide N-acetylgalactosaminyltransferase 8	Q9NY28		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_002045	Macrophage mannose receptor 1	P22897	1EGG 1EGI 5XTS 5XTW 6INN 6INO 6INU 6INV 6IOE 7JUB 7JUC 7JUD 7JUE 7JUF 7JUG 7JUH 7L61 7L62 7L63 7L64 7L65 7L66 7L67 7L68	Homo sapiens (human)	9606	cargo receptor activity cell surface cellular response to interleukin-4 cellular response to lipopolysaccharide cellular response to type II interferon endosome membrane mannose binding plasma membrane receptor-mediated endocytosis signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0004888 GO:0005537 GO:0005886 GO:0006898 GO:0009986 GO:0010008 GO:0038023 GO:0038024 GO:0071222 GO:0071346 GO:0071353
GL_000766	Low affinity immunoglobulin epsilon Fc receptor	P06734	1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M	Homo sapiens (human)	9606	B cell antigen processing and presentation Fc receptor-mediated immune complex endocytosis IgE binding carbohydrate binding external side of plasma membrane extracellular exosome immune response integrin binding low-affinity IgE receptor activity macrophage activation metal ion binding plasma membrane positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of killing of cells of another organism positive regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase biosynthetic process	GO:0002450 GO:0002925 GO:0005178 GO:0005886 GO:0006955 GO:0009897 GO:0019769 GO:0019863 GO:0030246 GO:0042116 GO:0046872 GO:0051000 GO:0051712 GO:0051770 GO:0070062 GO:0160006
GL_001113	Sialic acid-binding Ig-like lectin 11	Q96RL6		Homo sapiens (human)	9606	carbohydrate binding cell adhesion phosphatase binding plasma membrane sialic acid binding	GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0033691
GL_000874	Placental protein 13-like	Q8TCE9	6K2Y 6K2Z	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix nucleoplasm	GO:0005654 GO:0006915 GO:0030246 GO:0062023
GL_000807	Neurocan core protein	O14594		Homo sapiens (human)	9606	Golgi lumen calcium ion binding carbohydrate binding cell adhesion central nervous system development extracellular region extracellular space glial cell differentiation hyaluronic acid binding lysosomal lumen perineuronal net positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0002052 GO:0005509 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0043202 GO:0045202 GO:0072534
GL_002829	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	4ZG6 4ZG7 4ZG9 4ZGA 5KXA 5M7M 5MHP 8C3O 8C3P	Homo sapiens (human)	9606	alkylglycerophosphoethanolamine phosphodiesterase activity calcium ion binding cell motility chemotaxis estrous cycle extracellular space hydrolase activity immune response lysophospholipase activity nucleic acid binding phosphatidylcholine catabolic process phosphodiesterase I activity phospholipid catabolic process plasma membrane polysaccharide binding positive regulation of epithelial cell migration positive regulation of lamellipodium morphogenesis positive regulation of peptidyl-tyrosine phosphorylation regulation of cell migration scavenger receptor activity sphingolipid catabolic process zinc ion binding	GO:0003676 GO:0004528 GO:0004622 GO:0005044 GO:0005509 GO:0005615 GO:0005886 GO:0006935 GO:0006955 GO:0008270 GO:0009395 GO:0010634 GO:0016787 GO:0030149 GO:0030247 GO:0030334 GO:0034638 GO:0044849 GO:0047391 GO:0048870 GO:0050731 GO:2000394

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