GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **126 - 150** of **298** in total

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GlyCosmos Lectin ▲	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_001087	Secretory phospholipase A2 receptor	Q13018	6JLI 7QSR	Homo sapiens (human)	9606		carbohydrate binding cell surface extracellular region negative regulation of arachidonic acid secretion negative regulation of phospholipase A2 activity oxidative stress-induced premature senescence phospholipase binding plasma membrane positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of arachidonic acid secretion positive regulation of cytokine production positive regulation of podocyte apoptotic process reactive oxygen species metabolic process receptor complex receptor-mediated endocytosis replicative senescence signaling receptor activity	GO:0001819 GO:0005576 GO:0005886 GO:0006898 GO:0009986 GO:0030246 GO:0038023 GO:0043235 GO:0043274 GO:0043517 GO:0072593 GO:0090238 GO:0090399 GO:0090403 GO:1900138 GO:1900139 GO:1904635
GL_001101	Serum amyloid P-component	P02743	1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	Homo sapiens (human)	9606		acute-phase response blood microparticle calcium ion binding carbohydrate binding chaperone-mediated protein complex assembly collagen-containing extracellular matrix complement component C1q complex binding extracellular exosome extracellular region extracellular space identical protein binding innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation of acute inflammatory response negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of monocyte differentiation negative regulation of viral entry into host cell negative regulation of viral process negative regulation of wound healing nucleus protein folding unfolded protein binding virion binding	GO:0001849 GO:0002674 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0006457 GO:0006953 GO:0030246 GO:0042802 GO:0044869 GO:0044871 GO:0045087 GO:0045656 GO:0046597 GO:0046790 GO:0048525 GO:0051082 GO:0051131 GO:0061045 GO:0062023 GO:0070062 GO:0072562 GO:1903016 GO:1903019
GL_001111	Sialic acid-binding Ig-like lectin 10	Q96LC7		Homo sapiens (human)	9606	5400	SH2 domain binding adaptive immune response carbohydrate binding cell adhesion extracellular region innate immune response negative regulation of inflammatory response to wounding phosphatase binding plasma membrane sialic acid binding	GO:0002250 GO:0005576 GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0033691 GO:0042169 GO:0045087 GO:0106015
GL_001113	Sialic acid-binding Ig-like lectin 11	Q96RL6		Homo sapiens (human)	9606		carbohydrate binding cell adhesion phosphatase binding plasma membrane sialic acid binding	GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0033691
GL_001114	Sialic acid-binding Ig-like lectin 12	Q96PQ1		Homo sapiens (human)	9606		carbohydrate binding cell adhesion plasma membrane sialic acid binding	GO:0005886 GO:0007155 GO:0030246 GO:0033691
GL_001117	Sialic acid-binding Ig-like lectin 14	Q08ET2		Homo sapiens (human)	9606		carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0033691 GO:0070821 GO:0101003
GL_001118	Sialic acid-binding Ig-like lectin 16	A6NMB1		Homo sapiens (human)	9606		carbohydrate binding cell adhesion plasma membrane positive regulation of defense response to bacterium positive regulation of interleukin-6 production sialic acid binding	GO:0005886 GO:0007155 GO:0030246 GO:0032755 GO:0033691 GO:1900426
GL_001119	Sialic acid-binding Ig-like lectin 5	O15389	2ZG1 2ZG2 2ZG3	Homo sapiens (human)	9606		carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane secretory granule membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0030667 GO:0033691 GO:0070821 GO:0101003
GL_001120	Sialic acid-binding Ig-like lectin 6	O43699		Homo sapiens (human)	9606		carbohydrate binding cell adhesion cell-cell signaling cytosol extracellular region membrane plasma membrane sialic acid binding	GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0007267 GO:0016020 GO:0030246 GO:0033691
GL_001121	Sialic acid-binding Ig-like lectin 7	Q9Y286	1NKO 1O7S 1O7V 2DF3 2G5R 2HRL	Homo sapiens (human)	9606	1976 5378 5388	carbohydrate binding cell adhesion plasma membrane sialic acid binding signaling receptor activity	GO:0005886 GO:0007155 GO:0030246 GO:0033691 GO:0038023
GL_001122	Sialic acid-binding Ig-like lectin 8	Q9NYZ4	2N7A 2N7B 7QU6 7QUH 7QUI	Homo sapiens (human)	9606		carbohydrate binding cell adhesion membrane plasma membrane sialic acid binding signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007155 GO:0007165 GO:0016020 GO:0030246 GO:0033691
GL_001123	Sialic acid-binding Ig-like lectin 9	Q9Y336		Homo sapiens (human)	9606		carbohydrate binding cell adhesion cell surface receptor signaling pathway plasma membrane secretory granule membrane sialic acid binding	GO:0005886 GO:0007155 GO:0007166 GO:0030246 GO:0030667 GO:0033691
GL_001127	Sialoadhesin	Q9BZZ2		Homo sapiens (human)	9606		carbohydrate binding cell-cell adhesion cell-matrix adhesion clathrin-dependent endocytosis of virus by host cell early endosome extracellular region inflammatory response late endosome membrane negative regulation of type I interferon production plasma membrane virion binding	GO:0005576 GO:0005769 GO:0005770 GO:0005886 GO:0006954 GO:0007160 GO:0016020 GO:0030246 GO:0032480 GO:0046790 GO:0075512 GO:0098609
GL_001143	Tetranectin	P05452	1HTN 1RJH 1TN3 3L9J	Homo sapiens (human)	9606		bone mineralization calcium ion binding carbohydrate binding cellular response to organic substance cellular response to transforming growth factor beta stimulus collagen-containing extracellular matrix cytoplasm extracellular exosome extracellular region extracellular space granular component heparin binding kringle domain binding ossification platelet dense granule lumen positive regulation of plasminogen activation	GO:0001503 GO:0001652 GO:0005509 GO:0005576 GO:0005615 GO:0005737 GO:0008201 GO:0010756 GO:0030246 GO:0030282 GO:0031089 GO:0036143 GO:0062023 GO:0070062 GO:0071310 GO:0071560
GL_001169	Versican core protein	P13611		Homo sapiens (human)	9606		Golgi lumen calcium ion binding carbohydrate binding cell adhesion cell recognition central nervous system development collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix structural constituent conferring compression resistance extracellular matrix extracellular region extracellular space glial cell differentiation glial cell migration glycosaminoglycan binding hyaluronic acid binding interphotoreceptor matrix lysosomal lumen membrane osteoblast differentiation perineuronal net photoreceptor outer segment positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0001649 GO:0001750 GO:0002052 GO:0005509 GO:0005539 GO:0005540 GO:0005576 GO:0005615 GO:0005788 GO:0005796 GO:0007155 GO:0007417 GO:0008037 GO:0008347 GO:0010001 GO:0016020 GO:0030021 GO:0030246 GO:0031012 GO:0033165 GO:0043202 GO:0045202 GO:0062023 GO:0072534
GL_001173	Very large A-kinase anchor protein	Q68DQ2		Homo sapiens (human)	9606		carbohydrate binding lens development in camera-type eye protein kinase A binding protein-containing complex structural constituent of eye lens visual perception	GO:0002088 GO:0005212 GO:0007601 GO:0030246 GO:0032991 GO:0051018
GL_001174	Vesicular integral-membrane protein VIP36	Q12907		Homo sapiens (human)	9606		COPII-coated ER to Golgi transport vesicle Golgi apparatus Golgi membrane carbohydrate binding cell surface endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment extracellular exosome extracellular space heat shock protein binding mannose binding metal ion binding plasma membrane positive regulation of phagocytosis protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	GO:0000139 GO:0005537 GO:0005615 GO:0005789 GO:0005793 GO:0005794 GO:0005886 GO:0006888 GO:0006890 GO:0009986 GO:0015031 GO:0030134 GO:0030246 GO:0031072 GO:0033116 GO:0046872 GO:0050766 GO:0070062
GL_001178	Zymogen granule membrane protein 16	O60844	3APA 3VY6 3VY7 3VZE 3VZF 3VZG 7O3I 7O4P 7O88	Homo sapiens (human)	9606		Golgi lumen carbohydrate binding collagen-containing extracellular matrix defense response to Gram-positive bacterium extracellular space mucus layer peptidoglycan binding protein transport suppression of symbiont entry into host zymogen granule membrane	GO:0005615 GO:0005796 GO:0015031 GO:0030246 GO:0042589 GO:0042834 GO:0050830 GO:0052373 GO:0062023 GO:0070701
GL_001183	1,4-alpha-glucan-branching enzyme	Q04446	4BZY 5CLT 5CLW	Homo sapiens (human)	9606		1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) 1,4-alpha-glucan branching enzyme activity carbohydrate binding cation binding cytoplasm cytosol extracellular exosome generation of precursor metabolites and energy glycogen biosynthetic process glycogen metabolic process hydrolase activity, hydrolyzing O-glycosyl compounds negative regulation of neuron apoptotic process starch metabolic process	GO:0003844 GO:0004553 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0005982 GO:0006091 GO:0030246 GO:0043169 GO:0043524 GO:0070062 GO:0102752
GL_001231	Alpha-mannosidase 2	Q16706		Homo sapiens (human)	9606		Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular exosome hydrolase activity, hydrolyzing N-glycosyl compounds in utero embryonic development liver development lung alveolus development mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity membrane metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization viral protein processing	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0016020 GO:0016799 GO:0019082 GO:0030246 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042 GO:0070062
GL_001235	Alpha-mannosidase 2C1	Q9NTJ4		Homo sapiens (human)	9606		alpha-mannosidase activity carbohydrate binding cytosol mannose metabolic process metal ion binding nucleoplasm oligosaccharide catabolic process	GO:0004559 GO:0005654 GO:0005829 GO:0006013 GO:0009313 GO:0030246 GO:0046872
GL_001238	Alpha-mannosidase 2x	P49641		Homo sapiens (human)	9606		Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding hydrolase activity, hydrolyzing N-glycosyl compounds mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004559 GO:0004572 GO:0006013 GO:0006486 GO:0006491 GO:0016799 GO:0030246 GO:0046872
GL_001363	Beta-glucuronidase	P08236	1BHG 3HN3	Homo sapiens (human)	9606		azurophil granule lumen beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen glucuronoside catabolic process glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lysosomal lumen membrane protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005576 GO:0005615 GO:0005975 GO:0006027 GO:0016020 GO:0019391 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904813
GL_001376	BOS complex subunit NOMO1	Q15155		Homo sapiens (human)	9606		carbohydrate binding endoplasmic reticulum membrane membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane ribosome binding	GO:0005789 GO:0016020 GO:0030246 GO:0043022 GO:0160063 GO:0160064
GL_001378	BOS complex subunit NOMO2	Q5JPE7		Homo sapiens (human)	9606		carbohydrate binding endoplasmic reticulum membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane protein-containing complex ribosome binding	GO:0005789 GO:0030246 GO:0032991 GO:0043022 GO:0160063 GO:0160064

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