GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **151 - 175** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs ▲	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_001087	Secretory phospholipase A2 receptor	Q13018	6JLI 7QSR	Homo sapiens (human)	9606	carbohydrate binding cell surface extracellular region negative regulation of arachidonic acid secretion negative regulation of phospholipase A2 activity oxidative stress-induced premature senescence phospholipase binding plasma membrane positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of arachidonic acid secretion positive regulation of cytokine production positive regulation of podocyte apoptotic process reactive oxygen species metabolic process receptor complex receptor-mediated endocytosis replicative senescence signaling receptor activity	GO:0001819 GO:0005576 GO:0005886 GO:0006898 GO:0009986 GO:0030246 GO:0038023 GO:0043235 GO:0043274 GO:0043517 GO:0072593 GO:0090238 GO:0090399 GO:0090403 GO:1900138 GO:1900139 GO:1904635
GL_000874	Placental protein 13-like	Q8TCE9	6K2Y 6K2Z	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix nucleoplasm	GO:0005654 GO:0006915 GO:0030246 GO:0062023
GL_002018	Galectin-16	A8MUM7	6LJP 6LJQ 6LJR	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix lactose binding positive regulation of T cell apoptotic process	GO:0006915 GO:0030246 GO:0030395 GO:0062023 GO:0070234
GL_000139	C-type lectin domain family 10 member A	Q8IUN9	6PUV 6PY1 6W12 6XIY	Homo sapiens (human)	9606	adaptive immune response carbohydrate binding endocytosis external side of plasma membrane fucose binding innate immune response mannose binding plasma membrane signaling receptor activity	GO:0002250 GO:0005537 GO:0005886 GO:0006897 GO:0009897 GO:0030246 GO:0038023 GO:0042806 GO:0045087
GL_000895	Polypeptide N-acetylgalactosaminyltransferase 12	Q8IXK2	6PXU	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_004553	Bis(monoacylglycero)phosphate synthase CLN5	O75503	6R99	Homo sapiens (human)	9606	Golgi apparatus bis(monoacylglycero)phosphate synthase activity brain development cytosol endoplasmic reticulum extracellular exosome glycosylation hydrolase activity, acting on glycosyl bonds long-chain acyl-CoA hydrolase activity lysosomal lumen acidification lysosomal membrane lysosome organization lysosome mannose binding membrane neurogenesis neuron maturation perinuclear region of cytoplasm positive regulation of GTP binding protein catabolic process retrograde transport, endosome to Golgi signal peptide processing vacuolar lumen visual perception	GO:0005537 GO:0005764 GO:0005765 GO:0005775 GO:0005783 GO:0005794 GO:0005829 GO:0006465 GO:0007040 GO:0007042 GO:0007420 GO:0007601 GO:0016020 GO:0016798 GO:0022008 GO:0030163 GO:0042147 GO:0042551 GO:0048471 GO:0052816 GO:0070062 GO:0070085 GO:0160121 GO:1904426
GL_001703	Malectin	Q14165	6S7T	Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane endoplasmic reticulum enzyme binding membrane oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation specific granule membrane	GO:0005783 GO:0005789 GO:0005886 GO:0006487 GO:0008250 GO:0016020 GO:0019899 GO:0030246 GO:0035579
GL_005117	Transmembrane prolyl 4-hydroxylase	Q9NXG6	6TP5	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding calcium ion binding endoplasmic reticulum membrane endoplasmic reticulum hypoxia-inducible factor-proline dioxygenase activity iron ion binding procollagen-proline 4-dioxygenase activity regulation of erythrocyte differentiation	GO:0004656 GO:0005506 GO:0005509 GO:0005783 GO:0005789 GO:0016706 GO:0031418 GO:0045646 GO:0160082
GL_002388	Neuronal pentraxin-1	Q15818	6YPE	Homo sapiens (human)	9606	axonogenesis involved in innervation cellular response to glucose stimulus cellular response to potassium ion central nervous system development chemical synaptic transmission endoplasmic reticulum glutamatergic synapse metal ion binding mitochondrial fragmentation involved in apoptotic process mitochondrial transport neurotransmitter receptor localization to postsynaptic specialization membrane postsynaptic density assembly synaptic cleft transport vesicle	GO:0005783 GO:0006839 GO:0007268 GO:0007417 GO:0030133 GO:0035865 GO:0043083 GO:0043653 GO:0046872 GO:0060385 GO:0071333 GO:0097107 GO:0098978 GO:0099645
GL_001413	Complement C4-B	P0C0L5	6YSQ	Homo sapiens (human)	9606	axon blood microparticle carbohydrate binding complement activation, classical pathway complement activation complement binding dendrite detection of molecule of bacterial origin endopeptidase inhibitor activity extracellular exosome extracellular region extracellular space inflammatory response innate immune response opsonization plasma membrane positive regulation of apoptotic cell clearance symbiont cell surface synapse	GO:0001848 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006954 GO:0006956 GO:0006958 GO:0008228 GO:0030246 GO:0030424 GO:0030425 GO:0032490 GO:0045087 GO:0045202 GO:0070062 GO:0072562 GO:0106139 GO:2000427
GL_000768	Lymphocyte antigen 75	O60449	7JPT 7JPU 8HBC	Homo sapiens (human)	9606	carbohydrate binding endocytosis external side of plasma membrane extracellular exosome immune response inflammatory response plasma membrane signaling receptor activity	GO:0005886 GO:0006897 GO:0006954 GO:0006955 GO:0009897 GO:0030246 GO:0038023 GO:0070062
GL_003651	ATP-dependent 6-phosphofructokinase, liver type	P17858	7LW1	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding canonical glycolysis cytosol extracellular exosome extracellular region ficolin-1-rich granule lumen fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose binding fructose-6-phosphate binding glycolytic process identical protein binding kinase binding membrane metal ion binding monosaccharide binding negative regulation of insulin secretion response to glucose secretory granule lumen	GO:0003872 GO:0005524 GO:0005576 GO:0005829 GO:0005945 GO:0006002 GO:0006096 GO:0009749 GO:0016020 GO:0016208 GO:0019900 GO:0030388 GO:0034774 GO:0042802 GO:0046676 GO:0046872 GO:0048029 GO:0061621 GO:0070061 GO:0070062 GO:0070095 GO:1904813
GL_002601	Glycogen [starch] synthase, muscle	P13807	7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ	Homo sapiens (human)	9606	cytoplasm cytosol glucose binding glycogen (starch) synthase activity glycogen biosynthetic process glycogen synthase activity, transferring glucose-1-phosphate heart development inclusion body membrane	GO:0004373 GO:0005536 GO:0005737 GO:0005829 GO:0005978 GO:0007507 GO:0016020 GO:0016234 GO:0061547
GL_003145	Protein phosphatase 1 regulatory subunit 3C	Q9UQK1	7QF7 7QFA 7QFB 7QM2	Homo sapiens (human)	9606	cytosol glycogen binding glycogen biosynthetic process glycogen metabolic process molecular adaptor activity protein phosphatase 1 binding protein phosphatase binding protein phosphatase type 1 complex protein serine/threonine phosphatase activity regulation of glycogen biosynthetic process	GO:0000164 GO:0004722 GO:0005829 GO:0005977 GO:0005978 GO:0005979 GO:0008157 GO:0019903 GO:0060090 GO:2001069
GL_002359	Pentraxin-related protein PTX3	P26022	7ZL1	Homo sapiens (human)	9606	(1->3)-beta-D-glucan binding complement component C1q complex binding extracellular matrix organization extracellular matrix extracellular region extracellular space identical protein binding inflammatory response innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation by host of viral process negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of viral entry into host cell opsonization ovarian cumulus expansion positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis response to yeast specific granule lumen tertiary granule lumen virion binding	GO:0001550 GO:0001849 GO:0001872 GO:0001878 GO:0005576 GO:0005615 GO:0006954 GO:0008228 GO:0030198 GO:0031012 GO:0035580 GO:0042802 GO:0044793 GO:0044869 GO:0044871 GO:0045087 GO:0045429 GO:0046597 GO:0046790 GO:0050766 GO:1903016 GO:1903019 GO:1904724
GL_002428	Sialic acid-binding Ig-like lectin 15	Q6ZMC9	7ZOZ	Homo sapiens (human)	9606	plasma membrane protein-containing complex regulation of actin cytoskeleton organization regulation of bone resorption regulation of osteoclast development	GO:0005886 GO:0032956 GO:0032991 GO:0045124 GO:2001204
GL_000330	Complement component C1q receptor	Q9NPY3	8A59 8IVD	Homo sapiens (human)	9606	calcium ion binding carbohydrate binding cell migration cell-cell adhesion complement component C1q complex binding external side of plasma membrane extracellular matrix binding extracellular matrix protein binding extracellular matrix ficolin-1-rich granule membrane macrophage activation phagocytosis plasma membrane secretory granule membrane signaling receptor activity specific granule membrane tertiary granule membrane	GO:0001849 GO:0005509 GO:0005886 GO:0006909 GO:0009897 GO:0016477 GO:0030246 GO:0030667 GO:0031012 GO:0035579 GO:0038023 GO:0042116 GO:0050840 GO:0070821 GO:0098609 GO:0101003 GO:1990430
GL_000551	Inactive cell surface hyaluronidase CEMIP2	Q9UHN6	8C6I	Homo sapiens (human)	9606	angiogenesis cadherin binding calcium ion binding carbohydrate binding cytosol extracellular exosome hyaluronan catabolic process intracellular membrane-bounded organelle membrane nucleolus plasma membrane regulation of sprouting angiogenesis	GO:0001525 GO:0005509 GO:0005730 GO:0005829 GO:0005886 GO:0016020 GO:0030214 GO:0030246 GO:0043231 GO:0045296 GO:0070062 GO:1903670
GL_001725	Neutral alpha-glucosidase AB	Q14697	8D43 8EMR	Homo sapiens (human)	9606	Golgi apparatus N-glycan processing RNA binding alpha-glucosidase activity carbohydrate binding carbohydrate metabolic process endoplasmic reticulum lumen extracellular exosome glucan 1,3-alpha-glucosidase activity glucosidase II complex intracellular membrane-bounded organelle melanosome membrane	GO:0003723 GO:0005788 GO:0005794 GO:0005975 GO:0006491 GO:0016020 GO:0017177 GO:0030246 GO:0033919 GO:0042470 GO:0043231 GO:0070062 GO:0090599
GL_001504	GDH/6PGL endoplasmic bifunctional protein	O95479	8EM2	Homo sapiens (human)	9606	6-phosphogluconolactonase activity NADP binding carbohydrate binding endoplasmic reticulum lumen endoplasmic reticulum glucose 1-dehydrogenase (NAD+) activity glucose 1-dehydrogenase (NADP+) activity glucose 1-dehydrogenase [NAD(P)] activity glucose metabolic process glucose-6-phosphate dehydrogenase activity pentose-phosphate shunt, oxidative branch regulation of cortisol biosynthetic process response to alcohol response to nutrient levels	GO:0004345 GO:0005783 GO:0005788 GO:0006006 GO:0009051 GO:0017057 GO:0030246 GO:0031667 GO:0047934 GO:0047935 GO:0047936 GO:0050661 GO:0097305 GO:2000064
GL_000249	Calnexin	P27824		Homo sapiens (human)	9606	ERAD pathway RNA binding calcium ion binding carbohydrate binding clathrin-dependent endocytosis endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum extracellular exosome lumenal side of endoplasmic reticulum membrane melanosome membrane membrane mitochondria-associated endoplasmic reticulum membrane mitochondrial membrane nuclear membrane presynapse protein folding in endoplasmic reticulum protein folding protein secretion synaptic vesicle endocytosis unfolded protein binding viral protein processing	GO:0003723 GO:0005509 GO:0005783 GO:0005788 GO:0005789 GO:0006457 GO:0009306 GO:0016020 GO:0019082 GO:0030246 GO:0031965 GO:0031966 GO:0033162 GO:0034975 GO:0036503 GO:0044233 GO:0044322 GO:0048488 GO:0051082 GO:0070062 GO:0072583 GO:0098553 GO:0098793
GL_001169	Versican core protein	P13611		Homo sapiens (human)	9606	Golgi lumen calcium ion binding carbohydrate binding cell adhesion cell recognition central nervous system development collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix structural constituent conferring compression resistance extracellular matrix extracellular region extracellular space glial cell differentiation glial cell migration glycosaminoglycan binding hyaluronic acid binding interphotoreceptor matrix lysosomal lumen membrane osteoblast differentiation perineuronal net photoreceptor outer segment positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0001649 GO:0001750 GO:0002052 GO:0005509 GO:0005539 GO:0005540 GO:0005576 GO:0005615 GO:0005788 GO:0005796 GO:0007155 GO:0007417 GO:0008037 GO:0008347 GO:0010001 GO:0016020 GO:0030021 GO:0030246 GO:0031012 GO:0033165 GO:0043202 GO:0045202 GO:0062023 GO:0072534
GL_000373	F-box only protein 2	Q9UK22		Homo sapiens (human)	9606	ERAD pathway SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process amyloid-beta binding carbohydrate binding cytoplasm cytosol denatured protein binding dendritic spine endoplasmic reticulum extrinsic component of postsynaptic membrane glutamatergic synapse glycoprotein catabolic process negative regulation of cell population proliferation protein modification process protein ubiquitination proteolysis regulation of protein catabolic process at postsynapse, modulating synaptic transmission regulation of protein ubiquitination ubiquitin protein ligase activity ubiquitin-protein transferase activity	GO:0001540 GO:0004842 GO:0005737 GO:0005783 GO:0005829 GO:0006508 GO:0006516 GO:0008285 GO:0016567 GO:0019005 GO:0030246 GO:0031146 GO:0031249 GO:0031396 GO:0036211 GO:0036503 GO:0043197 GO:0061630 GO:0098890 GO:0098978 GO:0099576
GL_000140	C-type lectin domain family 11 member A	Q9Y240		Homo sapiens (human)	9606	carbohydrate binding cytoplasm extracellular region extracellular space growth factor activity ossification positive regulation of cell population proliferation	GO:0001503 GO:0005576 GO:0005615 GO:0005737 GO:0008083 GO:0008284 GO:0030246
GL_001728	Neutral alpha-glucosidase C	Q8TET4		Homo sapiens (human)	9606	N-glycan processing alpha-1,4-glucosidase activity carbohydrate binding maltose alpha-glucosidase activity	GO:0004558 GO:0006491 GO:0030246 GO:0032450

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