GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **151 - 175** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID ▲	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_002829	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	4ZG6 4ZG7 4ZG9 4ZGA 5KXA 5M7M 5MHP 8C3O 8C3P	Homo sapiens (human)	9606	alkylglycerophosphoethanolamine phosphodiesterase activity calcium ion binding cell motility chemotaxis estrous cycle extracellular space hydrolase activity immune response lysophospholipase activity nucleic acid binding phosphatidylcholine catabolic process phosphodiesterase I activity phospholipid catabolic process plasma membrane polysaccharide binding positive regulation of epithelial cell migration positive regulation of lamellipodium morphogenesis positive regulation of peptidyl-tyrosine phosphorylation regulation of cell migration scavenger receptor activity sphingolipid catabolic process zinc ion binding	GO:0003676 GO:0004528 GO:0004622 GO:0005044 GO:0005509 GO:0005615 GO:0005886 GO:0006935 GO:0006955 GO:0008270 GO:0009395 GO:0010634 GO:0016787 GO:0030149 GO:0030247 GO:0030334 GO:0034638 GO:0044849 GO:0047391 GO:0048870 GO:0050731 GO:2000394
GL_001703	Malectin	Q14165	6S7T	Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane endoplasmic reticulum enzyme binding membrane oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation specific granule membrane	GO:0005783 GO:0005789 GO:0005886 GO:0006487 GO:0008250 GO:0016020 GO:0019899 GO:0030246 GO:0035579
GL_001629	Glucokinase regulatory protein	Q14397	4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS	Homo sapiens (human)	9606	amino sugar catabolic process carbohydrate binding carbon-oxygen lyase activity cytoplasm cytosol enzyme binding enzyme inhibitor activity ether hydrolase activity fructose-6-phosphate binding glucose homeostasis glucose sensor activity kinase inhibitor activity mitochondrion negative regulation of glucokinase activity nucleoplasm peptidoglycan turnover protein import into nucleus response to fructose response to glucose triglyceride homeostasis urate metabolic process	GO:0004857 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0006606 GO:0009254 GO:0009749 GO:0009750 GO:0016803 GO:0016835 GO:0019210 GO:0019899 GO:0030246 GO:0033132 GO:0042593 GO:0046348 GO:0046415 GO:0070095 GO:0070328 GO:0141089
GL_000914	Polypeptide N-acetylgalactosaminyltransferase 3	Q14435		Homo sapiens (human)	9606	Golgi apparatus Golgi cisterna membrane Golgi membrane O-glycan processing calcium ion binding carbohydrate binding carbohydrate metabolic process extracellular exosome fibroblast growth factor receptor signaling pathway manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation spermatogenesis	GO:0000139 GO:0004653 GO:0005509 GO:0005794 GO:0005975 GO:0006493 GO:0007283 GO:0008543 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471 GO:0070062
GL_001725	Neutral alpha-glucosidase AB	Q14697	8D43 8EMR	Homo sapiens (human)	9606	Golgi apparatus N-glycan processing RNA binding alpha-glucosidase activity carbohydrate binding carbohydrate metabolic process endoplasmic reticulum lumen extracellular exosome glucan 1,3-alpha-glucosidase activity glucosidase II complex intracellular membrane-bounded organelle melanosome membrane	GO:0003723 GO:0005788 GO:0005794 GO:0005975 GO:0006491 GO:0016020 GO:0017177 GO:0030246 GO:0033919 GO:0042470 GO:0043231 GO:0070062 GO:0090599
GL_001376	BOS complex subunit NOMO1	Q15155		Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane ribosome binding	GO:0005789 GO:0016020 GO:0030246 GO:0043022 GO:0160063 GO:0160064
GL_001720	Nectin-1	Q15223	3ALP 3SKU 3U82 3U83 4FMF 4MYW	Homo sapiens (human)	9606	adherens junction apical junction complex axon guidance carbohydrate binding cell adhesion molecule binding cell adhesion cell-cell adhesion cell-cell contact zone coreceptor activity dendrite desmosome organization enamel mineralization extracellular region growth cone membrane heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules hippocampal mossy fiber to CA3 synapse homophilic cell adhesion via plasma membrane adhesion molecules identical protein binding immune response iron ion transport lens morphogenesis in camera-type eye membrane plasma membrane presynaptic active zone membrane protein homodimerization activity protein localization to cell junction protein-containing complex binding regulation of synapse assembly retina development in camera-type eye viral entry into host cell virion binding virus receptor activity	GO:0001618 GO:0002089 GO:0002934 GO:0005576 GO:0005886 GO:0005912 GO:0006826 GO:0006955 GO:0007155 GO:0007156 GO:0007157 GO:0007411 GO:0015026 GO:0016020 GO:0030246 GO:0030425 GO:0032584 GO:0042802 GO:0042803 GO:0043296 GO:0044291 GO:0044877 GO:0046718 GO:0046790 GO:0048787 GO:0050839 GO:0051963 GO:0060041 GO:0070166 GO:0098609 GO:0098686 GO:1902414
GL_002010	Ficolin-2	Q15485	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T	Homo sapiens (human)	9606	antigen binding blood microparticle calcium-dependent protein binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway defense response to Gram-negative bacterium defense response to Gram-positive bacterium external side of plasma membrane extracellular exosome extracellular region extracellular space mannan binding metal ion binding opsonization positive regulation of opsonization proteoglycan binding proteolysis recognition of apoptotic cell serine-type endopeptidase complex signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0008228 GO:0009897 GO:0043394 GO:0043654 GO:0046872 GO:0048306 GO:0050829 GO:0050830 GO:0062023 GO:0070062 GO:0072562 GO:0097367 GO:1903028 GO:1905370 GO:2001065
GL_004706	Putative inactive beta-glucuronidase-like protein SMA3	Q15486		Homo sapiens (human)	9606	beta-glucuronidase activity carbohydrate binding extracellular space glucuronoside catabolic process nervous system development signaling receptor binding skeletal system development	GO:0001501 GO:0004566 GO:0005102 GO:0005615 GO:0007399 GO:0019391 GO:0030246
GL_000317	Chitinase-3-like protein 2	Q15782	4AY1 4P8U 4P8V 4P8W 4P8X	Homo sapiens (human)	9606	carbohydrate binding carbohydrate metabolic process chitin binding chitin catabolic process extracellular region extracellular space hydrolase activity	GO:0005576 GO:0005615 GO:0005975 GO:0006032 GO:0008061 GO:0016787 GO:0030246
GL_002388	Neuronal pentraxin-1	Q15818	6YPE	Homo sapiens (human)	9606	axonogenesis involved in innervation cellular response to glucose stimulus cellular response to potassium ion central nervous system development chemical synaptic transmission endoplasmic reticulum glutamatergic synapse metal ion binding mitochondrial fragmentation involved in apoptotic process mitochondrial transport neurotransmitter receptor localization to postsynaptic specialization membrane postsynaptic density assembly synaptic cleft transport vesicle	GO:0005783 GO:0006839 GO:0007268 GO:0007417 GO:0030133 GO:0035865 GO:0043083 GO:0043653 GO:0046872 GO:0060385 GO:0071333 GO:0097107 GO:0098978 GO:0099645
GL_001231	Alpha-mannosidase 2	Q16706		Homo sapiens (human)	9606	Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular exosome hydrolase activity, hydrolyzing N-glycosyl compounds in utero embryonic development liver development lung alveolus development mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity membrane metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization viral protein processing	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0016020 GO:0016799 GO:0019082 GO:0030246 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042 GO:0070062
GL_003157	Protein phosphatase 1 regulatory subunit 3A	Q16821	5ZQV	Homo sapiens (human)	9606	glycogen binding glycogen metabolic process membrane protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005977 GO:0005979 GO:0008157 GO:0016020 GO:2001069
GL_002665	UTP--glucose-1-phosphate uridylyltransferase	Q16851	3R2W 3R3I 4R7P	Homo sapiens (human)	9606	UDP-glucose metabolic process UTP brain development cytoplasm cytosol extracellular exosome glucose 1-phosphate metabolic process glucose binding glycogen biosynthetic process glycogen metabolic process identical protein binding metal ion binding nucleus pyrimidine ribonucleotide binding	GO:0003983 GO:0005536 GO:0005634 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0006011 GO:0007420 GO:0019255 GO:0032557 GO:0042802 GO:0046872 GO:0070062
GL_000146	C-type lectin domain family 12 member B	Q2HXU8		Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane melanocyte proliferation natural killer cell inhibitory signaling pathway negative regulation of natural killer cell mediated cytotoxicity negative regulation of receptor signaling pathway via STAT negative regulation of signaling receptor activity protein phosphatase binding protein-containing complex signaling receptor inhibitor activity	GO:0002769 GO:0009897 GO:0019903 GO:0030246 GO:0030547 GO:0032991 GO:0045953 GO:0097325 GO:1904893 GO:2000272
GL_001761	Probable maltase-glucoamylase 2	Q2M2H8		Homo sapiens (human)	9606	alpha-1,4-glucosidase activity carbohydrate binding carbohydrate metabolic process glucan 1,4-alpha-glucosidase activity membrane	GO:0004339 GO:0004558 GO:0005975 GO:0016020 GO:0030246
GL_002486	Hexokinase HKDC1	Q2TB90		Homo sapiens (human)	9606	ATP binding carbohydrate phosphorylation cytoplasm cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process intracellular glucose homeostasis mitochondrial membrane mitochondrion photoreceptor inner segment	GO:0001678 GO:0001917 GO:0004340 GO:0005524 GO:0005536 GO:0005737 GO:0005739 GO:0005829 GO:0006006 GO:0006096 GO:0008865 GO:0031966 GO:0046835 GO:0051156
GL_004979	Prolyl 3-hydroxylase 1	Q32P28		Homo sapiens (human)	9606	L-ascorbic acid binding bone development chaperone-mediated protein folding collagen metabolic process cytoplasm endoplasmic reticulum lumen endoplasmic reticulum extracellular exosome iron ion binding membrane negative regulation of cell population proliferation negative regulation of post-translational protein modification nucleus positive regulation of neuron projection development procollagen-proline 3-dioxygenase activity protein folding protein hydroxylation protein stabilization protein-containing complex regulation of protein secretion	GO:0005506 GO:0005634 GO:0005737 GO:0005783 GO:0005788 GO:0006457 GO:0008285 GO:0010976 GO:0016020 GO:0018126 GO:0019797 GO:0031418 GO:0032963 GO:0032991 GO:0050708 GO:0050821 GO:0060348 GO:0061077 GO:0070062 GO:1901874
GL_000516	Galectin-9B	Q3B8N2		Homo sapiens (human)	9606	carbohydrate binding cytosol galactoside binding negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of type II interferon production nucleus positive regulation of gene expression	GO:0005634 GO:0005829 GO:0010628 GO:0016936 GO:0030246 GO:0032689 GO:2000562
GL_000519	Galectin-related protein	Q3ZCW2	2JJ6 3B9C	Homo sapiens (human)	9606	carbohydrate binding	GO:0030246
GL_000933	Polypeptide N-acetylgalactosaminyltransferase-like 6	Q49A17		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via threonine protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0018243 GO:0030246 GO:0046872
GL_000397	FRAS1-related extracellular matrix protein 1	Q5H8C1		Homo sapiens (human)	9606	anatomical structure morphogenesis basement membrane carbohydrate binding cell communication cell-matrix adhesion collagen-containing extracellular matrix craniofacial suture morphogenesis extracellular region membrane metal ion binding	GO:0005576 GO:0005604 GO:0007154 GO:0007160 GO:0009653 GO:0016020 GO:0030246 GO:0046872 GO:0062023 GO:0097094
GL_001378	BOS complex subunit NOMO2	Q5JPE7		Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane protein-containing complex ribosome binding	GO:0005789 GO:0030246 GO:0032991 GO:0043022 GO:0160063 GO:0160064
GL_001998	Collectin-12	Q5KU26	2OX8	Homo sapiens (human)	9606	carbohydrate mediated signaling cellular response to exogenous dsRNA collagen trimer collagen-containing extracellular matrix defense response to bacterium defense response endocytic vesicle membrane extracellular space galactose binding innate immune response low-density lipoprotein particle binding membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane raft organization plasma membrane scavenger receptor activity toll-like receptor 3 signaling pathway	GO:0005044 GO:0005534 GO:0005581 GO:0005615 GO:0005886 GO:0006910 GO:0006952 GO:0009756 GO:0016020 GO:0030169 GO:0030666 GO:0034138 GO:0038187 GO:0042742 GO:0044857 GO:0045087 GO:0046872 GO:0062023 GO:0071360
GL_000143	C-type lectin domain family 12 member A	Q5QGZ9		Homo sapiens (human)	9606	carbohydrate binding plasma membrane signal transduction signaling receptor regulator activity specific granule membrane tertiary granule membrane transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007165 GO:0030246 GO:0030545 GO:0035579 GO:0070821

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