GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **176 - 200** of **298** in total

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GlyCosmos Lectin ▲	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_001741	Pleiotrophin	P21246	2N6F	Homo sapiens (human)	9606	Schaffer collateral - CA1 synapse bone mineralization carbohydrate binding chondroitin sulfate binding decidualization dendrite arborization dendrite regeneration endoplasmic reticulum estrous cycle extracellular region extracellular space growth factor activity heparin binding integrin binding integrin-mediated signaling pathway learning leukocyte chemotaxis involved in inflammatory response memory molecular function activator activity negative regulation of long-term synaptic potentiation negative regulation of neuroblast proliferation nervous system development oogenesis ossification involved in bone remodeling plasma membrane positive regulation of axon regeneration positive regulation of bone mineralization positive regulation of cell division positive regulation of cell population proliferation positive regulation of dendrite development positive regulation of hepatocyte proliferation positive regulation of leukocyte chemotaxis positive regulation of neuron projection development positive regulation of oligodendrocyte differentiation positive regulation of ossification positive regulation of stem cell differentiation protein kinase binding protein phosphatase inhibitor activity protein-containing complex receptor clustering regulation of endothelial cell migration regulation of hemopoiesis regulation of myelination regulation of stem cell population maintenance regulation of synaptic plasticity response to auditory stimulus tissue regeneration transmembrane receptor protein tyrosine phosphatase signaling pathway	GO:0002232 GO:0002690 GO:0004864 GO:0005178 GO:0005576 GO:0005615 GO:0005783 GO:0005886 GO:0007185 GO:0007229 GO:0007399 GO:0007406 GO:0007612 GO:0007613 GO:0008083 GO:0008201 GO:0008284 GO:0010594 GO:0010976 GO:0010996 GO:0019901 GO:0030246 GO:0030282 GO:0030501 GO:0031104 GO:0031641 GO:0032991 GO:0035374 GO:0042246 GO:0043113 GO:0043932 GO:0044849 GO:0045778 GO:0046697 GO:0048167 GO:0048477 GO:0048680 GO:0048714 GO:0051781 GO:0098685 GO:0140059 GO:0140677 GO:1900006 GO:1900272 GO:1903706 GO:2000036 GO:2000347 GO:2000738
GL_001761	Probable maltase-glucoamylase 2	Q2M2H8		Homo sapiens (human)	9606	alpha-1,4-glucosidase activity carbohydrate binding carbohydrate metabolic process glucan 1,4-alpha-glucosidase activity membrane	GO:0004339 GO:0004558 GO:0005975 GO:0016020 GO:0030246
GL_001781	Protein AMBP	P02760	1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD	Homo sapiens (human)	9606	IgA binding blood microparticle calcium channel inhibitor activity calcium oxalate binding carbohydrate binding cell adhesion cell surface collagen-containing extracellular matrix cytosol endoplasmic reticulum extracellular exosome extracellular region extracellular space female pregnancy heme binding heme catabolic process mitochondrial inner membrane negative regulation of JNK cascade negative regulation of immune response nuclear membrane oxidoreductase activity plasma membrane protein homodimerization activity serine-type endopeptidase inhibitor activity	GO:0004867 GO:0005576 GO:0005615 GO:0005743 GO:0005783 GO:0005829 GO:0005886 GO:0007155 GO:0007565 GO:0009986 GO:0016491 GO:0019855 GO:0019862 GO:0020037 GO:0030246 GO:0031965 GO:0042167 GO:0042803 GO:0046329 GO:0046904 GO:0050777 GO:0062023 GO:0070062 GO:0072562
GL_001829	Sclerostin	Q9BQB4	2K8P 3SOV 6L6R	Homo sapiens (human)	9606	BMP binding BMP signaling pathway DNA-binding transcription factor binding Golgi apparatus canonical Wnt signaling pathway carbohydrate binding cellular response to parathyroid hormone stimulus extracellular region extracellular space heparin binding localization molecular function inhibitor activity negative regulation of BMP signaling pathway negative regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of ossification negative regulation of protein-containing complex assembly ossification positive regulation of DNA-templated transcription protein-containing complex response to mechanical stimulus	GO:0001503 GO:0005576 GO:0005615 GO:0005794 GO:0008201 GO:0009612 GO:0030178 GO:0030246 GO:0030279 GO:0030509 GO:0030514 GO:0031333 GO:0032991 GO:0036122 GO:0045893 GO:0051179 GO:0060070 GO:0071374 GO:0090090 GO:0140297 GO:0140678
GL_001835	Sorbitol dehydrogenase	Q00796	1PL6 1PL7 1PL8	Homo sapiens (human)	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_001840	Sucrase-isomaltase, intestinal	P14410	3LPO 3LPP	Homo sapiens (human)	9606	Golgi apparatus alpha-1,4-glucosidase activity apical plasma membrane brush border carbohydrate binding extracellular exosome oligo-1,6-glucosidase activity plasma membrane polysaccharide digestion sucrose alpha-glucosidase activity sucrose catabolic process	GO:0004558 GO:0004574 GO:0004575 GO:0005794 GO:0005886 GO:0005903 GO:0005987 GO:0016324 GO:0030246 GO:0044245 GO:0070062
GL_001891	Zona pellucida sperm-binding protein 3	P21754		Homo sapiens (human)	9606	acrosin binding binding of sperm to zona pellucida blastocyst formation carbohydrate binding collagen-containing extracellular matrix egg coat formation egg coat extracellular matrix structural constituent extracellular matrix extracellular region extracellular space humoral immune response mediated by circulating immunoglobulin identical protein binding negative regulation of DNA-templated transcription negative regulation of binding of sperm to zona pellucida oocyte development plasma membrane positive regulation of DNA-templated transcription positive regulation of T cell proliferation positive regulation of acrosomal vesicle exocytosis positive regulation of acrosome reaction positive regulation of antral ovarian follicle growth positive regulation of humoral immune response positive regulation of inflammatory response positive regulation of interleukin-4 production positive regulation of leukocyte migration positive regulation of ovarian follicle development positive regulation of type II interferon production positive regulation of type IV hypersensitivity receptor ligand activity structural constituent of egg coat	GO:0001809 GO:0001825 GO:0002455 GO:0002687 GO:0002922 GO:0005201 GO:0005576 GO:0005615 GO:0005886 GO:0007339 GO:0030246 GO:0031012 GO:0032190 GO:0032729 GO:0032753 GO:0035803 GO:0035804 GO:0035805 GO:0042102 GO:0042802 GO:0045892 GO:0045893 GO:0048018 GO:0048599 GO:0050729 GO:0062023 GO:2000344 GO:2000360 GO:2000368 GO:2000386 GO:2000388
GL_001982	Asialoglycoprotein receptor 1	P07306	1DV8 5JPV 5JQ1 6YAU	Homo sapiens (human)	9606	asialoglycoprotein receptor activity cellular response to extracellular stimulus external side of plasma membrane extracellular region fucose binding identical protein binding mannose binding metal ion binding plasma membrane receptor-mediated endocytosis signaling receptor activity	GO:0004873 GO:0005537 GO:0005576 GO:0005886 GO:0006898 GO:0009897 GO:0031668 GO:0038023 GO:0042802 GO:0042806 GO:0046872
GL_001986	Asialoglycoprotein receptor 2	P07307		Homo sapiens (human)	9606	asialoglycoprotein receptor activity cell surface receptor signaling pathway endocytosis endoplasmic reticulum quality control compartment external side of plasma membrane fucose binding mannose binding perinuclear region of cytoplasm plasma membrane signaling receptor activity	GO:0004873 GO:0005537 GO:0005886 GO:0006897 GO:0007166 GO:0009897 GO:0038023 GO:0042806 GO:0044322 GO:0048471
GL_001991	C-type lectin domain family 18 member A	A5D8T8		Homo sapiens (human)	9606	Golgi apparatus endoplasmic reticulum endosome extracellular space polysaccharide binding	GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0030247
GL_001992	C-type lectin domain family 18 member B	Q6UXF7		Homo sapiens (human)	9606	Golgi apparatus endosome extracellular space polysaccharide binding sarcoplasmic reticulum	GO:0005615 GO:0005768 GO:0005794 GO:0016529 GO:0030247
GL_001993	C-type lectin domain family 18 member C	Q8NCF0		Homo sapiens (human)	9606	Golgi apparatus endoplasmic reticulum endosome extracellular space polysaccharide binding	GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0030247
GL_001998	Collectin-12	Q5KU26	2OX8	Homo sapiens (human)	9606	carbohydrate mediated signaling cellular response to exogenous dsRNA collagen trimer collagen-containing extracellular matrix defense response to bacterium defense response endocytic vesicle membrane extracellular space galactose binding innate immune response low-density lipoprotein particle binding membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane raft organization plasma membrane scavenger receptor activity toll-like receptor 3 signaling pathway	GO:0005044 GO:0005534 GO:0005581 GO:0005615 GO:0005886 GO:0006910 GO:0006952 GO:0009756 GO:0016020 GO:0030169 GO:0030666 GO:0034138 GO:0038187 GO:0042742 GO:0044857 GO:0045087 GO:0046872 GO:0062023 GO:0071360
GL_002002	E-selectin	P16581	1ESL 1G1T 4C16 4CSY 6EYI 6EYJ 6EYK	Homo sapiens (human)	9606	actin filament-based process activation of phospholipase C activity calcium-mediated signaling caveola clathrin-coated pit cortical cytoskeleton external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response leukocyte cell-cell adhesion leukocyte migration involved in inflammatory response leukocyte tethering or rolling membrane raft metal ion binding oligosaccharide binding perinuclear region of cytoplasm phospholipase binding plasma membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of receptor internalization regulation of inflammatory response response to cytokine response to interleukin-1 response to lipopolysaccharide response to tumor necrosis factor sialic acid binding transmembrane signaling receptor activity	GO:0002092 GO:0002523 GO:0002687 GO:0004888 GO:0005615 GO:0005886 GO:0005901 GO:0005905 GO:0006954 GO:0007157 GO:0007159 GO:0007202 GO:0009897 GO:0019722 GO:0030029 GO:0030863 GO:0032496 GO:0033691 GO:0034097 GO:0034612 GO:0043274 GO:0045121 GO:0046872 GO:0048471 GO:0050727 GO:0050901 GO:0070492 GO:0070555 GO:1903238
GL_002010	Ficolin-2	Q15485	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T	Homo sapiens (human)	9606	antigen binding blood microparticle calcium-dependent protein binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway defense response to Gram-negative bacterium defense response to Gram-positive bacterium external side of plasma membrane extracellular exosome extracellular region extracellular space mannan binding metal ion binding opsonization positive regulation of opsonization proteoglycan binding proteolysis recognition of apoptotic cell serine-type endopeptidase complex signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0008228 GO:0009897 GO:0043394 GO:0043654 GO:0046872 GO:0048306 GO:0050829 GO:0050830 GO:0062023 GO:0070062 GO:0072562 GO:0097367 GO:1903028 GO:1905370 GO:2001065
GL_002017	Galectin-12	Q96DT0		Homo sapiens (human)	9606	cytoplasm cytosol galactoside binding intrinsic apoptotic signaling pathway lactose binding mitochondrion negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of type II interferon production nucleus positive regulation of gene expression	GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0010628 GO:0016936 GO:0030395 GO:0032689 GO:0097193 GO:2000562
GL_002018	Galectin-16	A8MUM7	6LJP 6LJQ 6LJR	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix lactose binding positive regulation of T cell apoptotic process	GO:0006915 GO:0030246 GO:0030395 GO:0062023 GO:0070234
GL_002022	Intelectin-1	Q8WWA0	4WMQ 4WMY 6USC	Homo sapiens (human)	9606	brush border membrane calcium ion binding extracellular exosome extracellular region extracellular space identical protein binding membrane raft oligosaccharide binding positive regulation of glucose import positive regulation of protein phosphorylation protein homotrimerization receptor complex response to nematode side of membrane	GO:0001934 GO:0005509 GO:0005576 GO:0005615 GO:0009624 GO:0031526 GO:0042802 GO:0043235 GO:0045121 GO:0046326 GO:0070062 GO:0070207 GO:0070492 GO:0098552
GL_002024	Intelectin-2	Q8WWU7		Homo sapiens (human)	9606	extracellular space metal ion binding oligosaccharide binding	GO:0005615 GO:0046872 GO:0070492
GL_002041	Lithostathine-1-alpha	P05451	1LIT 1QDD	Homo sapiens (human)	9606	antimicrobial humoral immune response mediated by antimicrobial peptide collagen-containing extracellular matrix disruption of cell wall in another organism extracellular exosome extracellular space growth factor activity molecular function inhibitor activity oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation response to peptide hormone signaling receptor activity	GO:0005615 GO:0008083 GO:0008284 GO:0038023 GO:0042834 GO:0043434 GO:0044278 GO:0061844 GO:0062023 GO:0070062 GO:0070492 GO:0140678
GL_002042	Lithostathine-1-beta	P48304		Homo sapiens (human)	9606	antimicrobial humoral immune response mediated by antimicrobial peptide collagen-containing extracellular matrix disruption of cell wall in another organism extracellular exosome extracellular space oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation response to peptide hormone signaling receptor activity	GO:0005615 GO:0008284 GO:0038023 GO:0042834 GO:0043434 GO:0044278 GO:0061844 GO:0062023 GO:0070062 GO:0070492
GL_002045	Macrophage mannose receptor 1	P22897	1EGG 1EGI 5XTS 5XTW 6INN 6INO 6INU 6INV 6IOE 7JUB 7JUC 7JUD 7JUE 7JUF 7JUG 7JUH 7L61 7L62 7L63 7L64 7L65 7L66 7L67 7L68	Homo sapiens (human)	9606	cargo receptor activity cell surface cellular response to interleukin-4 cellular response to lipopolysaccharide cellular response to type II interferon endosome membrane mannose binding plasma membrane receptor-mediated endocytosis signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0004888 GO:0005537 GO:0005886 GO:0006898 GO:0009986 GO:0010008 GO:0038023 GO:0038024 GO:0071222 GO:0071346 GO:0071353
GL_002047	P-selectin	P16109	1FSB 1G1Q 1G1R 1G1S 1HES	Homo sapiens (human)	9606	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules calcium-dependent protein binding calcium-mediated signaling using intracellular calcium source cell adhesion cell-cell adhesion defense response to Gram-negative bacterium external side of plasma membrane extracellular space fucose binding glycosphingolipid binding heparin binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response integrin binding leukocyte cell-cell adhesion leukocyte tethering or rolling lipopolysaccharide binding oligosaccharide binding plasma membrane platelet alpha granule membrane platelet dense granule membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of platelet activation regulation of integrin activation response to cytokine response to lipopolysaccharide sialic acid binding	GO:0001530 GO:0002687 GO:0005178 GO:0005509 GO:0005615 GO:0005886 GO:0006954 GO:0007155 GO:0007157 GO:0007159 GO:0008201 GO:0009897 GO:0010572 GO:0016339 GO:0031088 GO:0031092 GO:0032496 GO:0033623 GO:0033691 GO:0034097 GO:0035584 GO:0042806 GO:0043208 GO:0048306 GO:0050829 GO:0050901 GO:0051897 GO:0070492 GO:0098609 GO:1903238
GL_002053	Protein ERGIC-53	P49257	3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE	Homo sapiens (human)	9606	COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane Golgi membrane Golgi organization blood coagulation collagen-containing extracellular matrix endoplasmic reticulum membrane endoplasmic reticulum organization endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum extracellular exosome mannose binding membrane metal ion binding negative regulation of protein targeting to mitochondrion positive regulation of organelle organization protein folding protein transport sarcomere unfolded protein binding	GO:0000139 GO:0005537 GO:0005783 GO:0005789 GO:0005793 GO:0006457 GO:0006888 GO:0007029 GO:0007030 GO:0007596 GO:0010638 GO:0012507 GO:0015031 GO:0016020 GO:0030017 GO:0030134 GO:0033116 GO:0046872 GO:0051082 GO:0062023 GO:0070062 GO:1903215
GL_002057	Protein ERGIC-53-like	Q9HAT1		Homo sapiens (human)	9606	COPII-coated ER to Golgi transport vesicle Golgi membrane collagen-containing extracellular matrix endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment mannose binding	GO:0000139 GO:0005537 GO:0005789 GO:0005793 GO:0006888 GO:0030134 GO:0033116 GO:0062023

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