GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	March 3, 2025
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **1 - 25** of **297** in total

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GlyCosmos Lectin ▼	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_005296	Contactin-2	Q02246	2OM5 8K3J 8K53 9BA4 9BA5	Homo sapiens (human)	9606	G protein-coupled adenosine receptor signaling pathway adult walking behavior axon guidance axon initial segment axon axonal fasciculation carbohydrate binding cell adhesion cell surface cell-cell adhesion mediator activity central nervous system myelination cerebral cortex GABAergic interneuron migration clustering of voltage-gated potassium channels dendrite self-avoidance establishment of localization in cell establishment of protein localization to juxtaparanode region of axon fat cell differentiation homophilic cell adhesion via plasma membrane adhesion molecules juxtaparanode region of axon learning microtubule cytoskeleton organization myelin sheath negative regulation of neuron differentiation neuronal cell body node of Ranvier plasma membrane positive regulation of adenosine receptor signaling pathway positive regulation of protein processing postsynaptic membrane presynaptic membrane organization protein localization to juxtaparanode region of axon protein processing receptor internalization reduction of food intake in response to dietary excess regulation of astrocyte differentiation regulation of axon diameter regulation of cell morphogenesis regulation of neuronal synaptic plasticity side of membrane synapse organization synapse	GO:0000226 GO:0001973 GO:0002023 GO:0005886 GO:0007155 GO:0007156 GO:0007411 GO:0007413 GO:0007612 GO:0007628 GO:0009986 GO:0010954 GO:0016485 GO:0021853 GO:0022010 GO:0022604 GO:0030246 GO:0030424 GO:0031133 GO:0031623 GO:0033268 GO:0043025 GO:0043194 GO:0043209 GO:0044224 GO:0045163 GO:0045202 GO:0045211 GO:0045444 GO:0045665 GO:0048168 GO:0048710 GO:0050808 GO:0051649 GO:0060168 GO:0070593 GO:0071205 GO:0071206 GO:0097090 GO:0098552 GO:0098632
GL_005293	Ketohexokinase	P50053	2HLZ 2HQQ 2HW1 3B3L 3NBV 3NBW 3NC2 3NC9 3NCA 3Q92 3QA2 3QAI 3RO4 5WBM 5WBO 5WBP 5WBQ 5WBR 5WBZ 6UL7 6W0N 6W0W 6W0X 6W0Y 6W0Z 8OME 8OMF 8OMJ 8OMK 8UG1 8UG3 9FHD 9FHE	Homo sapiens (human)	9606	ATP binding cytoplasm cytosol extracellular exosome fructose binding fructose metabolic process identical protein binding ketohexokinase activity protein homodimerization activity regulation of glycogen metabolic process response to fructose response to glucose response to insulin response to sucrose response to zinc ion	GO:0004454 GO:0005524 GO:0005737 GO:0005829 GO:0006000 GO:0009744 GO:0009749 GO:0009750 GO:0010043 GO:0032868 GO:0042802 GO:0042803 GO:0070061 GO:0070062 GO:0070873
GL_005280	Prolyl 4-hydroxylase subunit alpha-3	Q7Z4N8		Homo sapiens (human)	9606	L-ascorbic acid binding endoplasmic reticulum lumen endoplasmic reticulum iron ion binding procollagen-proline 4-dioxygenase activity	GO:0004656 GO:0005506 GO:0005783 GO:0005788 GO:0031418
GL_005250	Prolyl hydroxylase EGLN3	Q9H6Z9		Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity DNA damage response L-ascorbic acid binding activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process cellular response to hypoxia cytoplasm cytosol ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity nucleoplasm nucleus peptidyl-proline 4-dioxygenase activity protein hydroxylation regulation of cell population proliferation regulation of neuron apoptotic process response to hypoxia	GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0006974 GO:0008198 GO:0016706 GO:0018126 GO:0031418 GO:0031545 GO:0042127 GO:0043523 GO:0071456 GO:0160082
GL_005235	Prolyl 3-hydroxylase 3	Q8IVL6		Homo sapiens (human)	9606	L-ascorbic acid binding catalytic complex collagen biosynthetic process collagen metabolic process endoplasmic reticulum iron ion binding negative regulation of cell population proliferation peptidyl-lysine hydroxylation procollagen-proline 3-dioxygenase activity	GO:0005506 GO:0005783 GO:0008285 GO:0017185 GO:0019797 GO:0031418 GO:0032963 GO:0032964 GO:1902494
GL_005207	Prolyl 4-hydroxylase subunit alpha-1	P13674	1TJC 2V5F 2YQ8 4BT8 4BT9 4BTA 4BTB	Homo sapiens (human)	9606	L-ascorbic acid binding collagen fibril organization endoplasmic reticulum lumen endoplasmic reticulum identical protein binding intracellular membrane-bounded organelle iron ion binding membrane mitochondrion procollagen-proline 4-dioxygenase activity procollagen-proline 4-dioxygenase complex	GO:0004656 GO:0005506 GO:0005739 GO:0005783 GO:0005788 GO:0016020 GO:0016222 GO:0030199 GO:0031418 GO:0042802 GO:0043231
GL_005179	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Q02809		Homo sapiens (human)	9606	L-ascorbic acid binding catalytic complex endoplasmic reticulum membrane endoplasmic reticulum epidermis development extracellular exosome iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0008544 GO:0017185 GO:0030867 GO:0031418 GO:0070062 GO:1902494
GL_005175	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	O60568	6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE	Homo sapiens (human)	9606	Golgi apparatus L-ascorbic acid binding basement membrane assembly collagen fibril organization collagen metabolic process collagen-containing extracellular matrix endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum endothelial cell morphogenesis epidermis morphogenesis extracellular exosome extracellular space hydroxylysine biosynthetic process in utero embryonic development iron ion binding lung morphogenesis metal ion binding neural tube development peptidyl-lysine hydroxylation procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity protein O-linked glycosylation protein localization rough endoplasmic reticulum small molecule binding trans-Golgi network vasodilation	GO:0001701 GO:0001886 GO:0005506 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005791 GO:0005794 GO:0005802 GO:0006493 GO:0008104 GO:0008475 GO:0017185 GO:0021915 GO:0030199 GO:0031418 GO:0032963 GO:0033823 GO:0036094 GO:0042311 GO:0046872 GO:0046947 GO:0048730 GO:0050211 GO:0060425 GO:0062023 GO:0070062 GO:0070831
GL_005165	Peptidyl-glycine alpha-amidating monooxygenase	P19021		Homo sapiens (human)	9606	L-ascorbic acid binding calcium ion binding copper ion binding extracellular exosome extracellular region fatty acid primary amide biosynthetic process membrane peptide amidation peptidylamidoglycolate lyase activity peptidylglycine monooxygenase activity response to zinc ion secretory granule membrane transport vesicle membrane zinc ion binding	GO:0001519 GO:0004504 GO:0004598 GO:0005507 GO:0005509 GO:0005576 GO:0008270 GO:0010043 GO:0016020 GO:0030658 GO:0030667 GO:0031418 GO:0062112 GO:0070062
GL_005149	Prolyl 4-hydroxylase subunit alpha-2	O15460	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC	Homo sapiens (human)	9606	L-ascorbic acid binding cytosol electron transfer activity endoplasmic reticulum lumen endoplasmic reticulum intracellular membrane-bounded organelle iron ion binding nucleoplasm procollagen-proline 4-dioxygenase activity	GO:0004656 GO:0005506 GO:0005654 GO:0005783 GO:0005788 GO:0005829 GO:0009055 GO:0031418 GO:0043231
GL_005117	Transmembrane prolyl 4-hydroxylase	Q9NXG6	6TP5	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding calcium ion binding endoplasmic reticulum membrane endoplasmic reticulum hypoxia-inducible factor-proline dioxygenase activity iron ion binding procollagen-proline 4-dioxygenase activity regulation of erythrocyte differentiation	GO:0004656 GO:0005506 GO:0005509 GO:0005783 GO:0005789 GO:0016706 GO:0031418 GO:0045646 GO:0160082
GL_005093	Prolyl 3-hydroxylase 2	Q8IVL5		Homo sapiens (human)	9606	Golgi apparatus L-ascorbic acid binding basement membrane collagen metabolic process cytosol endoplasmic reticulum lumen endoplasmic reticulum intracellular membrane-bounded organelle iron ion binding negative regulation of cell population proliferation nucleoplasm peptidyl-proline hydroxylation procollagen-proline 3-dioxygenase activity sarcoplasmic reticulum	GO:0005506 GO:0005604 GO:0005654 GO:0005783 GO:0005788 GO:0005794 GO:0005829 GO:0008285 GO:0016529 GO:0019511 GO:0019797 GO:0031418 GO:0032963 GO:0043231
GL_005071	Prolyl 3-hydroxylase OGFOD1	Q8N543	4NHX 4NHY	Homo sapiens (human)	9606	L-ascorbic acid binding cell population proliferation cytoplasm cytoplasmic stress granule cytosol iron ion binding nucleoplasm peptidyl-proline 3-dioxygenase activity peptidyl-proline dioxygenase activity peptidyl-proline hydroxylation protein hydroxylation regulation of translational termination stress granule assembly	GO:0005506 GO:0005654 GO:0005737 GO:0005829 GO:0006449 GO:0008283 GO:0010494 GO:0018126 GO:0019511 GO:0031418 GO:0031543 GO:0031544 GO:0034063
GL_005069	Phytanoyl-CoA dioxygenase, peroxisomal	O14832	2A1X	Homo sapiens (human)	9606	2-oxobutyrate catabolic process 2-oxoglutarate metabolic process 9+0 non-motile cilium L-ascorbic acid binding carboxylic acid binding cytosol fatty acid alpha-oxidation ferrous iron binding isoprenoid metabolic process methyl-branched fatty acid metabolic process peroxisomal matrix peroxisome phytanoyl-CoA dioxygenase activity	GO:0001561 GO:0005777 GO:0005782 GO:0005829 GO:0006103 GO:0006720 GO:0008198 GO:0019606 GO:0031406 GO:0031418 GO:0048244 GO:0097089 GO:0097731
GL_005016	Prolyl hydroxylase EGLN2	Q96KS0	5V1B	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cell redox homeostasis cellular response to hypoxia cytoplasm ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity intracellular estrogen receptor signaling pathway nucleoplasm nucleus oxygen sensor activity peptidyl-proline 4-dioxygenase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline positive regulation of protein catabolic process regulation of cell growth regulation of neuron apoptotic process response to hypoxia	GO:0001558 GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0008198 GO:0016706 GO:0018401 GO:0019826 GO:0030520 GO:0031418 GO:0031545 GO:0043523 GO:0045454 GO:0045732 GO:0071456 GO:0160082
GL_004979	Prolyl 3-hydroxylase 1	Q32P28		Homo sapiens (human)	9606	L-ascorbic acid binding bone development chaperone-mediated protein folding collagen metabolic process cytoplasm endoplasmic reticulum lumen endoplasmic reticulum extracellular exosome iron ion binding membrane negative regulation of cell population proliferation negative regulation of post-translational protein modification nucleus positive regulation of neuron projection development procollagen-proline 3-dioxygenase activity protein folding protein hydroxylation protein stabilization protein-containing complex regulation of protein secretion	GO:0005506 GO:0005634 GO:0005737 GO:0005783 GO:0005788 GO:0006457 GO:0008285 GO:0010976 GO:0016020 GO:0018126 GO:0019797 GO:0031418 GO:0032963 GO:0032991 GO:0050708 GO:0050821 GO:0060348 GO:0061077 GO:0070062 GO:1901874
GL_004978	Egl nine homolog 1	Q9GZT9	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4 6ZBN 6ZBO 7Q5V 7Q5X 7UJV 7UMP 8J1K 8Q5S 8Q64 8Q6D 8Q6E	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cardiac muscle tissue morphogenesis cellular response to hypoxia cytoplasm cytosol enzyme binding ferrous iron binding glutamatergic synapse heart trabecula formation hypoxia-inducible factor-proline dioxygenase activity intracellular iron ion homeostasis intracellular membrane-bounded organelle intracellular oxygen homeostasis labyrinthine layer development negative regulation of DNA-binding transcription factor activity negative regulation of cyclic-nucleotide phosphodiesterase activity nucleus peptidyl-proline 4-dioxygenase activity peptidyl-proline dioxygenase activity positive regulation of transcription by RNA polymerase II postsynaptic density regulation of angiogenesis regulation of modification of postsynaptic structure regulation protein catabolic process at postsynapse response to hypoxia response to nitric oxide ventricular septum morphogenesis	GO:0001666 GO:0005634 GO:0005737 GO:0005829 GO:0006879 GO:0008198 GO:0014069 GO:0016706 GO:0019899 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043231 GO:0043433 GO:0045765 GO:0045944 GO:0051344 GO:0055008 GO:0060347 GO:0060412 GO:0060711 GO:0071456 GO:0071731 GO:0098978 GO:0099159 GO:0140252 GO:0160082
GL_004965	Dopamine beta-hydroxylase	P09172	4ZEL	Homo sapiens (human)	9606	L-ascorbic acid binding behavioral response to ethanol blood vessel remodeling catalytic activity centriolar satellite chemical synaptic transmission chromaffin granule lumen chromaffin granule membrane copper ion binding cytoplasm dopamine beta-monooxygenase activity dopamine catabolic process endoplasmic reticulum extracellular region extracellular space fear response glucose homeostasis homoiothermy intracellular membrane-bounded organelle leukocyte mediated immunity leukocyte migration locomotory behavior maternal behavior membrane memory norepinephrine biosynthetic process octopamine biosynthetic process positive regulation of cold-induced thermogenesis positive regulation of vasoconstriction regulation of extrinsic apoptotic signaling pathway regulation of vascular associated smooth muscle cell proliferation regulation of vascular endothelial cell proliferation response to amphetamine response to pain secretory granule lumen secretory granule membrane synapse transport vesicle membrane vasoconstriction visual learning	GO:0001974 GO:0001975 GO:0002443 GO:0003824 GO:0004500 GO:0005507 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0006589 GO:0007268 GO:0007613 GO:0007626 GO:0008542 GO:0016020 GO:0030658 GO:0030667 GO:0031418 GO:0034451 GO:0034466 GO:0034774 GO:0042309 GO:0042310 GO:0042420 GO:0042421 GO:0042584 GO:0042593 GO:0042596 GO:0042711 GO:0043231 GO:0045202 GO:0045907 GO:0048149 GO:0048265 GO:0050900 GO:0120162 GO:1904705 GO:1905562 GO:2001236
GL_004944	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2	Q6N063		Homo sapiens (human)	9606	L-ascorbic acid binding dioxygenase activity iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0005506 GO:0016705 GO:0031418 GO:0051213
GL_004926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	O00469		Homo sapiens (human)	9606	L-ascorbic acid binding endoplasmic reticulum membrane endoplasmic reticulum extracellular exosome hydroxylysine biosynthetic process iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity protein modification process response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0017185 GO:0030867 GO:0031418 GO:0036211 GO:0046947 GO:0070062
GL_004920	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3	Q6PK18		Homo sapiens (human)	9606	L-ascorbic acid binding dioxygenase activity iron ion binding membrane oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0005506 GO:0016020 GO:0016705 GO:0031418 GO:0051213
GL_004899	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	Q96Q83	2IUW 8JNK 8JNR	Homo sapiens (human)	9606	DNA dealkylation involved in DNA repair L-ascorbic acid binding cell population proliferation cytosol ferrous iron binding mRNA N1-methyladenosine dioxygenase activity mitochondrion negative regulation of cytoplasmic translation nucleoplasm nucleus oxidative DNA demethylase activity oxidative RNA demethylase activity	GO:0005634 GO:0005654 GO:0005739 GO:0005829 GO:0006307 GO:0008198 GO:0008283 GO:0031418 GO:0035515 GO:0035516 GO:1990930 GO:2000766
GL_004645	Dolichol-phosphate mannosyltransferase subunit 1	O60762		Homo sapiens (human)	9606	GDP-mannose metabolic process GPI anchor biosynthetic process alcohol binding dolichol metabolic process dolichol-linked oligosaccharide biosynthetic process dolichol-phosphate-mannose synthase complex dolichyl-phosphate beta-D-mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum membrane endoplasmic reticulum mannose binding membrane metal ion binding nucleus protein N-linked glycosylation via asparagine protein O-linked mannosylation protein mannosylation response to oxygen levels	GO:0004169 GO:0004582 GO:0005537 GO:0005634 GO:0005783 GO:0005789 GO:0006488 GO:0006506 GO:0016020 GO:0018279 GO:0019348 GO:0019673 GO:0033185 GO:0035268 GO:0035269 GO:0043178 GO:0046872 GO:0070482
GL_004621	Collectin-10	Q9Y6Z7		Homo sapiens (human)	9606	Golgi apparatus cell surface pattern recognition receptor signaling pathway chemoattractant activity collagen trimer complement activation, lectin pathway cranial skeletal system development cytoplasm external side of plasma membrane extracellular region extracellular space mannose binding multivesicular body positive regulation of opsonization proteolysis serine-type endopeptidase complex	GO:0001867 GO:0002752 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0005737 GO:0005771 GO:0005794 GO:0006508 GO:0009897 GO:0042056 GO:1903028 GO:1904888 GO:1905370
GL_004606	Basigin	P35613	3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8 8XEJ	Homo sapiens (human)	9606	Golgi membrane acrosomal membrane angiogenesis basolateral plasma membrane cadherin binding cell surface receptor signaling pathway decidualization embryo implantation endoplasmic reticulum membrane endosome endothelial tube morphogenesis extracellular exosome focal adhesion intracellular membrane-bounded organelle mannose binding melanosome membrane mitochondrion neural retina development neutrophil chemotaxis odontogenesis of dentin-containing tooth photoreceptor cell maintenance photoreceptor inner segment photoreceptor outer segment plasma membrane positive regulation of endothelial cell migration positive regulation of interleukin-6 production positive regulation of matrix metallopeptidase secretion positive regulation of vascular endothelial growth factor production positive regulation of viral entry into host cell protein localization to plasma membrane response to cAMP response to mercury ion response to peptide hormone sarcolemma signaling receptor activity virus receptor activity	GO:0000139 GO:0001525 GO:0001618 GO:0001750 GO:0001917 GO:0002080 GO:0003407 GO:0005537 GO:0005739 GO:0005768 GO:0005789 GO:0005886 GO:0005925 GO:0007166 GO:0007566 GO:0010575 GO:0010595 GO:0016020 GO:0016323 GO:0030593 GO:0032755 GO:0038023 GO:0042383 GO:0042470 GO:0042475 GO:0043231 GO:0043434 GO:0045296 GO:0045494 GO:0046598 GO:0046689 GO:0046697 GO:0051591 GO:0061154 GO:0070062 GO:0072659 GO:1904466

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