GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	March 3, 2025
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **1 - 25** of **297** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID ▲	PDB IDs	LfDB IDs	Organism	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_003320	Fucose mutarotase	A2VDF0			Homo sapiens (human)	9606		L-fucose mutarotase activity cytosol fucose binding fucose metabolic process fucosylation racemase and epimerase activity, acting on carbohydrates and derivatives	GO:0005829 GO:0006004 GO:0016857 GO:0036065 GO:0036373 GO:0042806
GL_000631	Killer cell lectin-like receptor subfamily G member 2	A4D1S0			Homo sapiens (human)	9606		carbohydrate binding membrane	GO:0016020 GO:0030246
GL_000534	Grifin	A4D1Z8			Homo sapiens (human)	9606		carbohydrate binding	GO:0030246
GL_001991	C-type lectin domain family 18 member A	A5D8T8			Homo sapiens (human)	9606		Golgi apparatus endoplasmic reticulum endosome extracellular space polysaccharide binding	GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0030247
GL_001118	Sialic acid-binding Ig-like lectin 16	A6NMB1			Homo sapiens (human)	9606		carbohydrate binding cell adhesion plasma membrane positive regulation of defense response to bacterium positive regulation of interleukin-6 production sialic acid binding	GO:0005886 GO:0007155 GO:0030246 GO:0032755 GO:0033691 GO:1900426
GL_002018	Galectin-16	A8MUM7	6LJP 6LJQ 6LJR		Homo sapiens (human)	9606		apoptotic process carbohydrate binding lactose binding positive regulation of T cell apoptotic process	GO:0006915 GO:0030246 GO:0030395 GO:0070234
GL_003163	Protein phosphatase 1 regulatory subunit 3G	B7ZBB8			Homo sapiens (human)	9606		glucose homeostasis glycogen binding glycogen biosynthetic process positive regulation of glycogen biosynthetic process protein phosphatase 1 binding protein phosphatase type 1 complex regulation of glycogen biosynthetic process	GO:0000164 GO:0005978 GO:0005979 GO:0008157 GO:0042593 GO:0045725 GO:2001069
GL_000627	Killer cell lectin-like receptor subfamily F member 2	D3W0D1	4IOP		Homo sapiens (human)	9606		carbohydrate binding natural killer cell degranulation plasma membrane positive regulation of cytokine production protein homodimerization activity	GO:0001819 GO:0005886 GO:0030246 GO:0042803 GO:0043320
GL_000353	Doublecortin domain-containing protein 1	M0R2J8			Homo sapiens (human)	9606		Flemming body carbohydrate binding cell division cytoplasm intracellular signal transduction microtubule binding microtubule midbody mitotic spindle regulation of mitotic cytokinesis	GO:0005737 GO:0005874 GO:0008017 GO:0030246 GO:0030496 GO:0035556 GO:0051301 GO:0072686 GO:0090543 GO:1902412
GL_000514	Galectin-9 Aliases: Gal 9 Galectin-9 Human Galectin 9	O00182	2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	LfDB0274	Homo sapiens (human)	9606	1935 2987	ERK1 and ERK2 cascade carbohydrate binding cellular response to type II interferon cellular response to virus chemotaxis collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding enzyme binding extracellular space female pregnancy galactose binding galactoside binding inflammatory response maternal process involved in female pregnancy natural killer cell tolerance induction negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of activated T cell proliferation negative regulation of chemokine production negative regulation of gene expression negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of tumor necrosis factor production negative regulation of type II interferon production nucleus p38MAPK cascade positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of NF-kappaB transcription factor activity positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of activated T cell autonomous cell death positive regulation of canonical NF-kappaB signal transduction positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell chemotaxis positive regulation of dendritic cell differentiation positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of monocyte chemotactic protein-1 production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of transforming growth factor beta production positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of viral entry into host cell response to interleukin-1 response to lipopolysaccharide	GO:0002519 GO:0005534 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0006935 GO:0006954 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032682 GO:0032689 GO:0032720 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032736 GO:0032753 GO:0032755 GO:0032757 GO:0032760 GO:0032834 GO:0038066 GO:0043123 GO:0043305 GO:0045953 GO:0046007 GO:0046598 GO:0048030 GO:0051092 GO:0060135 GO:0062023 GO:0070241 GO:0070371 GO:0070374 GO:0070555 GO:0071346 GO:0071636 GO:0071639 GO:0098586 GO:1901224 GO:2000510 GO:2000562 GO:2000563 GO:2000670 GO:2001190 GO:2001200 GO:2001269
GL_000509	Galectin-8 Aliases: Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9	LfDB0273	Homo sapiens (human)	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_004572	Beta-mannosidase	O00462			Homo sapiens (human)	9606		azurophil granule membrane beta-mannosidase activity glycoprotein catabolic process lysosomal lumen mannose binding oligosaccharide catabolic process plasma membrane protein modification process	GO:0004567 GO:0005537 GO:0005886 GO:0006516 GO:0009313 GO:0035577 GO:0036211 GO:0043202
GL_004926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	O00469			Homo sapiens (human)	9606		L-ascorbic acid binding endoplasmic reticulum membrane endoplasmic reticulum extracellular exosome hydroxylysine biosynthetic process iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity protein modification process response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0017185 GO:0030867 GO:0031418 GO:0036211 GO:0046947 GO:0070062
GL_000384	Ficolin-1	O00602	2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP		Homo sapiens (human)	9606	3259 3262 3264	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway external side of plasma membrane extracellular region extracellular space ficolin-1-rich granule lumen metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell secretory granule lumen serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0009897 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0034774 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1904813 GO:1905370
GL_001699	Lysosomal alpha-mannosidase	O00754			Homo sapiens (human)	9606		alpha-mannosidase activity azurophil granule lumen carbohydrate binding extracellular exosome extracellular region extracellular space intracellular membrane-bounded organelle learning or memory lysosomal lumen lysosome mannose metabolic process metal ion binding nucleoplasm oligosaccharide catabolic process protein deglycosylation protein modification process	GO:0004559 GO:0005576 GO:0005615 GO:0005654 GO:0005764 GO:0006013 GO:0006517 GO:0007611 GO:0009313 GO:0030246 GO:0035578 GO:0036211 GO:0043202 GO:0043231 GO:0046872 GO:0070062
GL_000807	Neurocan core protein	O14594			Homo sapiens (human)	9606		Golgi lumen calcium ion binding carbohydrate binding cell adhesion central nervous system development extracellular region extracellular space glial cell differentiation hyaluronic acid binding lysosomal lumen perineuronal net positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0002052 GO:0005509 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0043202 GO:0045202 GO:0072534
GL_005069	Phytanoyl-CoA dioxygenase, peroxisomal	O14832	2A1X		Homo sapiens (human)	9606		2-oxobutyrate catabolic process 2-oxoglutarate metabolic process 9+0 non-motile cilium L-ascorbic acid binding carboxylic acid binding cytosol fatty acid alpha-oxidation ferrous iron binding isoprenoid metabolic process methyl-branched fatty acid metabolic process peroxisomal matrix peroxisome phytanoyl-CoA dioxygenase activity	GO:0001561 GO:0005777 GO:0005782 GO:0005829 GO:0006103 GO:0006720 GO:0008198 GO:0019606 GO:0031406 GO:0031418 GO:0048244 GO:0097089 GO:0097731
GL_001119	Sialic acid-binding Ig-like lectin 5	O15389	2ZG1 2ZG2 2ZG3		Homo sapiens (human)	9606		carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane secretory granule membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0030667 GO:0033691 GO:0070821 GO:0101003
GL_002299	Neural cell adhesion molecule 2	O15394	2DOC 2JLL 2KBG 2V5T 2VAJ 2WIM 2XY1 2XY2 2XYC		Homo sapiens (human)	9606		axon axonal fasciculation identical protein binding membrane neuron cell-cell adhesion nuclear body plasma membrane synaptic membrane	GO:0005886 GO:0007158 GO:0007413 GO:0016020 GO:0016604 GO:0030424 GO:0042802 GO:0097060
GL_005149	Prolyl 4-hydroxylase subunit alpha-2	O15460	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC		Homo sapiens (human)	9606		L-ascorbic acid binding cytosol electron transfer activity endoplasmic reticulum lumen endoplasmic reticulum intracellular membrane-bounded organelle iron ion binding nucleoplasm procollagen-proline 4-dioxygenase activity	GO:0004656 GO:0005506 GO:0005654 GO:0005783 GO:0005788 GO:0005829 GO:0009055 GO:0031418 GO:0043231
GL_001708	Maltase-glucoamylase	O43451	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP		Homo sapiens (human)	9606		alpha-1,4-glucosidase activity amylase activity apical plasma membrane carbohydrate binding catalytic activity dextrin catabolic process extracellular exosome ficolin-1-rich granule membrane glucan 1,4-alpha-glucosidase activity maltose catabolic process plasma membrane starch catabolic process tertiary granule membrane	GO:0000025 GO:0003824 GO:0004339 GO:0004558 GO:0005886 GO:0005983 GO:0016160 GO:0016324 GO:0030246 GO:0070062 GO:0070821 GO:0101003 GO:1901027
GL_001120	Sialic acid-binding Ig-like lectin 6	O43699			Homo sapiens (human)	9606		carbohydrate binding cell adhesion cell-cell signaling cytosol extracellular region membrane plasma membrane sialic acid binding	GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0007267 GO:0016020 GO:0030246 GO:0033691
GL_000768	Lymphocyte antigen 75	O60449	7JPT 7JPU 8HBC 8K8H		Homo sapiens (human)	9606		carbohydrate binding endocytosis external side of plasma membrane extracellular exosome immune response inflammatory response plasma membrane signaling receptor activity	GO:0005886 GO:0006897 GO:0006954 GO:0006955 GO:0009897 GO:0030246 GO:0038023 GO:0070062
GL_005175	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	O60568	6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE		Homo sapiens (human)	9606		Golgi apparatus L-ascorbic acid binding basement membrane assembly collagen fibril organization collagen metabolic process collagen-containing extracellular matrix endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum endothelial cell morphogenesis epidermis morphogenesis extracellular exosome extracellular space hydroxylysine biosynthetic process in utero embryonic development iron ion binding lung morphogenesis metal ion binding neural tube development peptidyl-lysine hydroxylation procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity protein O-linked glycosylation protein localization rough endoplasmic reticulum small molecule binding trans-Golgi network vasodilation	GO:0001701 GO:0001886 GO:0005506 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005791 GO:0005794 GO:0005802 GO:0006493 GO:0008104 GO:0008475 GO:0017185 GO:0021915 GO:0030199 GO:0031418 GO:0032963 GO:0033823 GO:0036094 GO:0042311 GO:0046872 GO:0046947 GO:0048730 GO:0050211 GO:0060425 GO:0062023 GO:0070062 GO:0070831
GL_004645	Dolichol-phosphate mannosyltransferase subunit 1	O60762			Homo sapiens (human)	9606		GDP-mannose metabolic process GPI anchor biosynthetic process alcohol binding dolichol metabolic process dolichol-linked oligosaccharide biosynthetic process dolichol-phosphate-mannose synthase complex dolichyl-phosphate beta-D-mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum membrane endoplasmic reticulum mannose binding membrane metal ion binding nucleus protein N-linked glycosylation via asparagine protein O-linked mannosylation protein mannosylation response to oxygen levels	GO:0004169 GO:0004582 GO:0005537 GO:0005634 GO:0005783 GO:0005789 GO:0006488 GO:0006506 GO:0016020 GO:0018279 GO:0019348 GO:0019673 GO:0033185 GO:0035268 GO:0035269 GO:0043178 GO:0046872 GO:0070482

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