GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **1 - 25** of **298** in total

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GlyCosmos Lectin ▲	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_000017	Adhesion G protein-coupled receptor L1	O94910		Homo sapiens (human)	9606	G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway axon calcium-mediated signaling using intracellular calcium source carbohydrate binding cell adhesion molecule binding cell surface receptor signaling pathway growth cone heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules latrotoxin receptor activity membrane neuron projection plasma membrane positive regulation of synapse maturation presynaptic membrane synapse	GO:0004930 GO:0005886 GO:0007157 GO:0007166 GO:0007186 GO:0007189 GO:0016020 GO:0016524 GO:0030246 GO:0030424 GO:0030426 GO:0035584 GO:0042734 GO:0043005 GO:0045202 GO:0050839 GO:0090129
GL_000020	Adhesion G protein-coupled receptor L2	O95490		Homo sapiens (human)	9606	G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway carbohydrate binding cell surface receptor signaling pathway latrotoxin receptor activity membrane	GO:0004930 GO:0007166 GO:0007186 GO:0007189 GO:0016020 GO:0016524 GO:0030246
GL_000022	Adhesion G protein-coupled receptor L3	Q9HAR2	5CMN 6VHH 7SF7 8DJG	Homo sapiens (human)	9606	G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway axon calcium ion binding carbohydrate binding cell surface receptor signaling pathway cell-cell adhesion via plasma-membrane adhesion molecules cell-cell junction glutamatergic synapse membrane neuron migration plasma membrane synapse assembly	GO:0001764 GO:0004930 GO:0005509 GO:0005886 GO:0005911 GO:0007166 GO:0007186 GO:0007189 GO:0007416 GO:0016020 GO:0030246 GO:0030424 GO:0098742 GO:0098978
GL_000051	Aggrecan core protein	P16112	4MD4 7RDV	Homo sapiens (human)	9606	Golgi lumen carbohydrate binding cell adhesion central nervous system development collagen-containing extracellular matrix extracellular matrix structural constituent extracellular region extracellular space glial cell differentiation hyaluronic acid binding lysosomal lumen metal ion binding perineuronal net positive regulation of neuroblast proliferation proteolysis skeletal system development synapse	GO:0001501 GO:0002052 GO:0005201 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0006508 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0043202 GO:0045202 GO:0046872 GO:0062023 GO:0072534
GL_000071	Attractin	O75882		Homo sapiens (human)	9606	Golgi apparatus carbohydrate binding cerebellum development extracellular exosome extracellular space inflammatory response myelination pigmentation plasma membrane regulation of multicellular organism growth signaling receptor activity	GO:0005615 GO:0005794 GO:0005886 GO:0006954 GO:0021549 GO:0030246 GO:0038023 GO:0040014 GO:0042552 GO:0043473 GO:0070062
GL_000075	Attractin-like protein 1	Q5VV63		Homo sapiens (human)	9606	G protein-coupled receptor signaling pathway Golgi apparatus Notch binding carbohydrate binding membrane	GO:0005112 GO:0005794 GO:0007186 GO:0016020 GO:0030246
GL_000077	B-cell differentiation antigen CD72	P21854		Homo sapiens (human)	9606	carbohydrate binding cell adhesion plasma membrane signaling receptor binding transmembrane signaling receptor activity	GO:0004888 GO:0005102 GO:0005886 GO:0007155 GO:0030246
GL_000082	B-cell receptor CD22	P20273	5VKJ 5VKM 5VL3 7O52	Homo sapiens (human)	9606	B cell activation CD4 receptor binding IgM binding carbohydrate binding cell adhesion cell surface cytoplasm early endosome external side of plasma membrane extracellular exosome membrane negative regulation of B cell receptor signaling pathway negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production neuronal cell body membrane plasma membrane protein phosphatase binding recycling endosome regulation of B cell proliferation regulation of endocytosis regulation of immune response sialic acid binding signaling receptor binding	GO:0001791 GO:0002638 GO:0005102 GO:0005737 GO:0005769 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0019903 GO:0030100 GO:0030246 GO:0030888 GO:0032809 GO:0033691 GO:0042113 GO:0042609 GO:0050776 GO:0050849 GO:0050859 GO:0055037 GO:0070062
GL_000102	Beta/gamma crystallin domain-containing protein 1	Q9Y4K1	2DAD 3CW3 6VRO	Homo sapiens (human)	9606	carbohydrate binding lens development in camera-type eye structural constituent of eye lens visual perception	GO:0002088 GO:0005212 GO:0007601 GO:0030246
GL_000103	Beta/gamma crystallin domain-containing protein 2	Q8N1P7		Homo sapiens (human)	9606	carbohydrate binding lens development in camera-type eye structural constituent of eye lens visual perception	GO:0002088 GO:0005212 GO:0007601 GO:0030246
GL_000106	Bone marrow proteoglycan	P13727	1H8U 2BRS 4QXX 7Y5N 8HGG	Homo sapiens (human)	9606	carbohydrate binding collagen-containing extracellular matrix defense response to bacterium defense response to nematode extracellular exosome extracellular matrix structural constituent conferring compression resistance extracellular region ficolin-1-rich granule lumen heparin binding immune response negative regulation of interleukin-10 production negative regulation of macrophage cytokine production positive regulation of interleukin-4 production transport vesicle	GO:0002215 GO:0005576 GO:0006955 GO:0008201 GO:0010936 GO:0030021 GO:0030133 GO:0030246 GO:0032693 GO:0032753 GO:0042742 GO:0062023 GO:0070062 GO:1904813
GL_000109	Brevican core protein	Q96GW7		Homo sapiens (human)	9606	Golgi lumen carbohydrate binding cell adhesion central nervous system development extracellular region extracellular space glial cell differentiation glutamatergic synapse hippocampus development hyaluronic acid binding lysosomal lumen perineuronal net positive regulation of neuroblast proliferation side of membrane skeletal system development synapse maturation synapse	GO:0001501 GO:0002052 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0007155 GO:0007417 GO:0010001 GO:0021766 GO:0030246 GO:0043202 GO:0045202 GO:0060074 GO:0072534 GO:0098552 GO:0098978
GL_000135	C-type lectin domain family 1 member A	Q8NC01		Homo sapiens (human)	9606	carbohydrate binding cell surface receptor signaling pathway plasma membrane signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007165 GO:0007166 GO:0030246
GL_000137	C-type lectin domain family 1 member B	Q9P126	2C6U 3WSR 3WWK	Homo sapiens (human)	9606	carbohydrate binding cell surface receptor signaling pathway cell surface defense response plasma membrane platelet formation signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0006952 GO:0007165 GO:0007166 GO:0009986 GO:0030220 GO:0030246
GL_000139	C-type lectin domain family 10 member A	Q8IUN9	6PUV 6PY1 6W12 6XIY	Homo sapiens (human)	9606	adaptive immune response carbohydrate binding endocytosis external side of plasma membrane fucose binding innate immune response mannose binding plasma membrane signaling receptor activity	GO:0002250 GO:0005537 GO:0005886 GO:0006897 GO:0009897 GO:0030246 GO:0038023 GO:0042806 GO:0045087
GL_000140	C-type lectin domain family 11 member A	Q9Y240		Homo sapiens (human)	9606	carbohydrate binding cytoplasm extracellular region extracellular space growth factor activity ossification positive regulation of cell population proliferation	GO:0001503 GO:0005576 GO:0005615 GO:0005737 GO:0008083 GO:0008284 GO:0030246
GL_000143	C-type lectin domain family 12 member A	Q5QGZ9		Homo sapiens (human)	9606	carbohydrate binding plasma membrane signal transduction signaling receptor regulator activity specific granule membrane tertiary granule membrane transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007165 GO:0030246 GO:0030545 GO:0035579 GO:0070821
GL_000146	C-type lectin domain family 12 member B	Q2HXU8		Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane melanocyte proliferation natural killer cell inhibitory signaling pathway negative regulation of natural killer cell mediated cytotoxicity negative regulation of receptor signaling pathway via STAT negative regulation of signaling receptor activity protein phosphatase binding protein-containing complex signaling receptor inhibitor activity	GO:0002769 GO:0009897 GO:0019903 GO:0030246 GO:0030547 GO:0032991 GO:0045953 GO:0097325 GO:1904893 GO:2000272
GL_000149	C-type lectin domain family 14 member A	Q86T13		Homo sapiens (human)	9606	carbohydrate binding cell migration involved in sprouting angiogenesis cell migration collagen-containing extracellular matrix external side of plasma membrane extracellular matrix binding extracellular matrix protein binding lymphangiogenesis vascular endothelial growth factor receptor-2 signaling pathway vascular endothelial growth factor receptor-3 signaling pathway	GO:0001946 GO:0002042 GO:0009897 GO:0016477 GO:0030246 GO:0036324 GO:0036325 GO:0050840 GO:0062023 GO:1990430
GL_000150	C-type lectin domain family 19 member A	Q6UXS0		Homo sapiens (human)	9606	carbohydrate binding extracellular region signaling receptor activity	GO:0005576 GO:0030246 GO:0038023
GL_000151	C-type lectin domain family 2 member A	Q6UVW9	4IOP	Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane natural killer cell mediated cytotoxicity plasma membrane protein homodimerization activity	GO:0005886 GO:0009897 GO:0030246 GO:0042267 GO:0042803
GL_000152	C-type lectin domain family 2 member B	Q92478		Homo sapiens (human)	9606	carbohydrate binding external side of plasma membrane identical protein binding plasma membrane	GO:0005886 GO:0009897 GO:0030246 GO:0042802
GL_000153	C-type lectin domain family 2 member D	Q9UHP7	4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT	Homo sapiens (human)	9606	carbohydrate binding cell surface receptor signaling pathway cell surface endoplasmic reticulum external side of plasma membrane membrane plasma membrane transmembrane signaling receptor activity	GO:0004888 GO:0005783 GO:0005886 GO:0007166 GO:0009897 GO:0009986 GO:0016020 GO:0030246
GL_000166	C-type lectin domain family 2 member L	P0C7M8		Homo sapiens (human)	9606	carbohydrate binding membrane	GO:0016020 GO:0030246
GL_000169	C-type lectin domain family 3 member A	O75596		Homo sapiens (human)	9606	carbohydrate binding extracellular space ossification skeletal system development	GO:0001501 GO:0001503 GO:0005615 GO:0030246

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