GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule ▲	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Helicobacter pylori	Adhesins	Sulfatide (CSE)	Sulfoglycosphingolipids	Human gastric mucosa	HSO3(-3)Gal(b1-1)Cer	Binding	2037054
Actinomyces naeslundii	Adhesins	N-Acetylgalactosamine	Monosaccharides	HL-60 promyelocytic leukemia cell line, Leukosialin (CD43)	GalNAc	Binding	11035744
Actinomyces naeslundii	Adhesins	Galactose	Monosaccharides	HL-60 promyelocytic leukemia cell line, Leukosialin (CD43)	Gal	Binding	11035744
Cryptococcus neoformans	Adhesins	N-Acetylglucosamine	Monosaccharides	Human lung epithelial cell line (A549)	GlcNAc	Binding	9453390
Cryptococcus neoformans	Adhesins	N-Acetylgalactosamine	Monosaccharides	Human lung epithelial cell line (A549)	GalNAc	Binding	9453390
Streptococcus pneumoniae	Adhesins	N-Acetylgalactosamine	Monosaccharides	Type-II lung cells, Vascular endothelial cells	GalNAc	Binding	7752878
Streptococcus pneumoniae	Adhesins	D-Mannose	Monosaccharides	Type-II lung cells, Vascular endothelial cells	Man	Binding	7752878
Streptococcus pneumoniae	Adhesins	D-Galactose	Monosaccharides	Vascular endothelial cells (only)	Gal	Binding	7752878
Streptococcus pneumoniae	Adhesins	Asialo-GM2 (Gangliotriosylceramide; GgO3)	Oligoglycosylceramides	Type-II lung cells, Vascular endothelial cells	GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7752878
Streptococcus pneumoniae	Adhesins	Gb4 (Globoside; Globotetraose; P antigen)	Oligoglycosylceramides	Type-II lung cells, Vascular endothelial cells	GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7752878