GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature ▲	Target Source	Glycan Sequence	Binding	PubMed ID
Pseudomonas aeruginosa	Pili	unnamed ligand	Disaccharides		GalNAc(b1-4)Gal	Binding	8574698
Actinomyces naeslundii	Unknown	unnamed ligand	Disaccharides		GalNAc(b1-3)Gal	Binding	12628483
Escherichia coli	SafS	α-sialyl-2-3-β-galactose	Disaccharides			Binding	12640357
Clostridium botulinum	Botulinum neurotoxin (type C)	GD1b	Disialoglycosphingolipids	Presynaptic neuronal cells	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium tetani	Tetanus toxin	GD1b	Disialoglycosphingolipids	Brain membrane	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	6257717
Clostridium botulinum	BoNT/C (located within amino acid residues 1122-1290)	GD1b	Disialoglycosphingolipids	Presynaptic neuronal cells	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Influenza virus	Hemagglutinin (HA)	GD1a	Disialoglycosphingolipids	Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas)	NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	11030743
Actinomyces naeslundii	Unknown	GD1b	Disialoglycosphingolipids	Human brain	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	2358461
Clostridium tetani	Unknown	GD1b	Disialoglycosphingolipids	Brain membrane	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	6257717
Actinomyces naeslundii	Type-2 fimbrial lectins	GD1a	Disialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	3804448