GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source ▲	Glycan Sequence	Binding	PubMed ID
Streptococcus suis	Adhesins	Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH)	Oligoglycosylceramides	Erythrocytes	Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7961660
Mycoplasma pneumoniae	Adhesins	hCG (human chorionic gonadotropin)	Glycoproteins	Erythrocytes		Binding	2470754
Escherichia coli	FimH	Mannose oligosaccharides	Oligosaccharides	Eukaryotic cells	Man	Binding	12640357
Bordetella pertussis	Pertactin	unknown carbohydrate ligand	Saccharides	Eukaryotic cells		Binding	11348687
Foot-and-mouth disease virus	Natural ligand of integrin [alpha]v[beta]3	Heparan sulfate	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	8764038
Foot-and-mouth disease virus	Natural ligand of integrin [alpha]v[beta]3	Heparan sulfate	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	8764038
Foot-and-mouth disease virus	Natural ligand of integrin [alpha]v[beta]3	Heparan sulfate	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	8764038
Foot-and-mouth disease virus	Natural ligand of integrin [alpha]v[beta]3	Heparan sulfate	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	8764038
Foot-and-mouth disease virus	VP1 (RGD peptide)	αvβ3 Integrin (independent of expression of Heparan sulfate on cell-sulface)	Glycoproteins	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparin	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	9557639