GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Binding	PubMed ID
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparin	Glycosaminoglycans	Extracellular matrix (ECM)	Binding	9557639
Bordetella pertussis	FHA (442-863)	Heparin	Glycosaminoglycans	WiDr cells, HeLa cells, Vero cells, Extracellular matrix (ECM)	Binding	11348687
Bordetella pertussis	FHA (442-863)	Heparin	Glycosaminoglycans	Respiratory epithelial cells	Binding	17106803
Foot-and-mouth disease virus	Natural ligand of integrin [alpha]v[beta]3	Heparin	Glycosaminoglycans	Extracellular matrix (ECM)	Binding	8764038
Herpes simplex virus	Unknown	Heparin	Glycosaminoglycans	Human cervical cells	Binding	9420059
Borrelia burgdorferi	BBK32	Heparin	Glycosaminoglycans	Mammalian cell surface	Binding	16368999
Shigella dysenteriae	Stx	Platelet-specific GSL (Stx band 0.03)	Glycosphingolipids	Human platelets	Binding	9712788
Cryptococcus neoformans	Adhesins	Sucrose	Monosaccharides	Human lung epithelial cell line (A549)	Binding	9453390
Cryptococcus neoformans	Adhesins	Inositol	Non-glycosylated Lipids	Human lung epithelial cell line (A549)	Binding	9453390
Clostridium botulinum	Botulinum neurotoxin (type D)	Phosphatidylethanolamine (PE)	Non-glycosylated Lipids	Presynaptic neuronal cells	Binding	18242046