GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species ▲	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Bordetella pertussis	CRD (carbohydrate recognition domain) of Fha (Filamentous Hemagglutinin)	Lactosylceramide (Lactocerebroside)	Diosylceramides	Respiratory ciliated cells, Alveolar macrophages	Gal(b1-4)Glc(b1-1)Cer	Binding	8514379
Bordetella pertussis	Pertussis toxin	Lactosylceramide (Lactocerebroside)	Diosylceramides	Human cilia of the respiratory epithelium	Gal(b1-4)Glc(b1-1)Cer	Binding	1729677
Bordetella pertussis	FHA (1141-1279)	Lactosylceramide (Lactocerebroside)	Diosylceramides	Ciliated epithelium of the respiratory tract	Gal(b1-4)Glc(b1-1)Cer	Binding	11348687
Bordetella pertussis	PT (subunit S2 of B oligomer)	Lactosylceramide (Lactocerebroside)	Diosylceramides	Human cilia of the respiratory epithelium	Gal(b1-4)Glc(b1-1)Cer	Binding	1729677
Bordetella pertussis	Adhesins	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Human lung, Human trachea	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	1918002
Bordetella pertussis	FimD	VLA-5 (very late activation antigen 5)	Glycoproteins	Monocytes		Binding	11348687
Bordetella pertussis	Pertactin	unknown carbohydrate ligand	Saccharides	Eukaryotic cells		Binding	11348687
Bordetella pertussis	Pertussis toxin	Haptoglobin	Glycoproteins			Binding	1729677
Bordetella pertussis	PT (subunit S2 of B oligomer)	Haptoglobin	Glycoproteins			Binding	1729677
Borrelia afzelii	Unknown	Dermatan sulfate	Glycosaminoglycans	Glial cells		Binding	10085013