GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule ▼	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Escherichia coli	CS3 (coli surface 3)-fimbriae	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Intestinal epithelium, Rabbit intestine	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7822033
Bordetella pertussis	CRD (carbohydrate recognition domain) of Fha (Filamentous Hemagglutinin)	Lactosylceramide (Lactocerebroside)	Diosylceramides	Respiratory ciliated cells, Alveolar macrophages	Gal(b1-4)Glc(b1-1)Cer	Binding	8514379
Escherichia coli	CFA/1	Sialic acid (α2,8)	Saccharides	Intestinal cells	NeuAc(a2-8)	Binding	16564136
Streptococcus pneumoniae	CBPs (choline-binding proteins)	nLc4Cer (Neolactotetraosylceramide; Paragloboside)	Oligoglycosylceramides	Cytokine-activated cells	Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	12640357
Streptococcus pneumoniae	CBPs (choline-binding proteins)	Sialic acid	Monosaccharides	Cytokine-activated cells		Binding	12640357
Trypanosoma cruzi	CBPs (carbohydrate-binding proteins)	High mannose glycans containig the Manα1-2Manα1-6Manα1-6 structure	Saccharides		Man(a1-2)Man(a1-6)Man(a1-6)	Binding	11555616
Vibrio alginolyticus	CBP (chitin-binding proteins) 53-kDa	N-Acetylglucosamine	Monosaccharides		GlcNAc	Binding	10049907
Vibrio harveyi	CBP (chitin-binding proteins) 53-kDa	N-Acetylglucosamine	Monosaccharides		GlcNAc	Binding	10049907
Vibrio cholerae	CBP (chitin-binding proteins) 36-kDa and 53-kDa	N-Acetylglucosamine	Monosaccharides		GlcNAc	Binding	10049907
Clostridium difficile	C-terminal domain of toxin A molecules	unnamed ligand	Oligosaccharides	Human colonic cells	Gal(a1-3)Gal(b1-4)GlcNAc	Binding	12507507