GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature ▲	Target Source	Glycan Sequence	Binding	PubMed ID
Influenza virus	Unknown	Endothelial cell-specific molecule (ESM)	Proteoglycans			Not Binding	1740131
Borrelia burgdorferi	"DbpA, DbpB, Bgp"	Decorin	Proteoglycans			Binding	16299269
Reovirus	Unknown	Sialic acid (α2,6)	Saccharides	Most organs including the central nervous system/heart/liver	NeuAc(a2-6)	Binding	18216114
Streptococcus pneumoniae	Adhesins	GlcNAc(b1-3)Gal sequence	Saccharides	Human endothelial cells	GlcNAc(b1-3)Gal	Binding	6886624
Actinomyces naeslundii	Type 2-fimbriae	β-linked galactosamine	Saccharides	Buccae	GalNAc(b 2:2	Binding	9712794
Actinomyces naeslundii	Type 2-fimbriae	β-linked galactosamine	Saccharides	Plaque	GalNAc(b 2:2	Binding	9712794
Actinomyces odontolyticus	Type 2-fimbriae	β-linked galactosamine	Saccharides	Buccae	GalNAc(b 2:2	Binding	9712794
Escherichia coli	20K-fimbriae	GlcNAc sequence	Saccharides	Human colon carcinoma Caco-2 cell line	GlcNAc	Binding	8557360
Actinomyces odontolyticus	Type 2-fimbriae	β-linked galactosamine	Saccharides	Plaque	GalNAc(b 2:2	Binding	9712794
Escherichia coli	18-kDa fimbrial adhesin	Galactose derivatives	Saccharides	HEp-2 cells	Gal	Binding	11368522