GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source ▼	Glycan Sequence	Binding	PubMed ID
Clostridium botulinum	Botulinum neurotoxin	GT1b (complex with synaptotagmin II)	Trisialoglycosphingolipids	Presynaptic membrane of neuromuscular junction		Binding	7527117
Clostridium botulinum	BoNT/B	GT1b (complex with synaptotagmin II)	Trisialoglycosphingolipids	Presynaptic membrane of neuromuscular junction		Binding	7527117
Escherichia coli	K88	Neoglycans (PSA-Lac)	Glycoproteins	Porcine serum albumin(PSA)		Binding	19101589
Escherichia coli	K88ab	GlcNAc residues in the core of N-glycan on pSTf (porcine serum transferrin)	N-glycans	Porcine serum		Binding	11953368
Escherichia coli	F1C	Glucosylceramide (d18:1/t18:0-16:0-24:0)	Monoglycosylceramides	Porcine kidney	Glc(b1-1)Cer	Not Binding	11877427
Escherichia coli	F1C	Sulfatide (CSE)	Sulfoglycosphingolipids	Porcine intestine	HSO3(-3)Gal(b1-1)Cer	Not Binding	11877427
Actinomyces naeslundii	Type-2 fimbrial lectins (130-kDa glycoprotein)	N-Acetylgalactosamine	Monosaccharides	Polymorphonuclear leukocytes (PMNs)	GalNAc	Binding	7790078
Actinomyces naeslundii	Type-2 fimbrial lectins (130-kDa glycoprotein)	Galactose	Monosaccharides	Polymorphonuclear leukocytes (PMNs)	Gal	Binding	7790078
Actinomyces naeslundii	Type-2 fimbrial lectins (130-kDa glycoprotein)	unnamed ligand	Oligosaccharides	Polymorphonuclear leukocytes (PMNs)	Gal(b1-3)GalNAc	Binding	7790078
Streptococcus gordonii	SspA/SspB (AgI/II family)	unknown carbohydrate ligand	Saccharides	Platelet		Binding	16177339