GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species ▲	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Streptococcus pneumoniae	Adhesins	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Type-II lung cells, Vascular endothelial cells	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7752878
Streptococcus pneumoniae	Unknown	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Chinchilla tracheal epithelium	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	10090858
Streptococcus pneumoniae	Unknown	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides		Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	3413084
Streptococcus pneumoniae	Unknown	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides		Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	12628483
Streptococcus pneumoniae	PsaA (Lary family)	unknown carbohydrate ligand	Saccharides	Nasopharynx, Alveolar epithelial cells		Binding	10341176
Streptococcus pneumoniae	PclA (pneumococcal collagen-like protein A)	unknown carbohydrate ligand	Saccharides	Detroit 562/A549 cell lines		Binding	18557785
Streptococcus pneumoniae	SpsA	IgA	Glycoproteins			Binding	10341176
Streptococcus pneumoniae	PspC (Lary family) (alias: SpsA/CbpA/PbcA/Hic)	IgA	Glycoproteins			Binding	12640357
Streptococcus pyogenes	Unknown	Fucosyl Asialo GM1	Oligoglycosylceramides		Fuc(a1-2)Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	3413084
Streptococcus pyogenes	Unknown	Asialo-GM2 (Gangliotriosylceramide; GgO3)	Oligoglycosylceramides		GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	3413084