GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature ▲	Target Source	Glycan Sequence	Binding	PubMed ID
Rotavirus	Unknown	I-active Sialyl lactoisooctaosylceramide	Sialoglycosphingolipids		Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	11160731
Rotavirus	Unknown	unnamed ligand	Sialoglycosphingolipids		Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	11160731
Rotavirus	Unknown	NeuGc3-nLc6Cer	Sialoglycosphingolipids		NeuGc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	11160731
Escherichia coli	Unknown	unnamed ligand	Sialoglycosphingolipids		NeuAc(a2-6)[NeuAc(a2-3)]Gal(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	2435422
Shigella dysenteriae	Unknown	unnamed ligand	Sialoglycosphingolipids		NeuAc(a2-6)[NeuAc(a2-3)]Gal(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	2435422
Influenza virus	Hemagglutinin (HA)	I-active ganglioside	Sialoglycosphingolipids		NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	12628483
Bordetella pertussis	PT (subunit S3 of B oligomer)	Gangliosides	Sialoglycosphingolipids	Human alveolar macrophages		Binding	1729677
Helicobacter pylori	Adhesins	Gangliosides	Sialoglycosphingolipids	Human leukocytes, Human neutrophils		Binding	10569742
Bordetella pertussis	Pertussis toxin	Gangliosides	Sialoglycosphingolipids	Human alveolar macrophages		Binding	1729677
Influenza virus	Unknown	Gangliosides	Sialoglycosphingolipids	Bovine brain		Binding	1740131