PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
Database | Last Updated |
---|---|
Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID ▲ |
---|---|---|---|---|---|---|---|
Adhesins
|
Fibrinogen
|
Glycoproteins
|
Human type II alveolar cells (A549)
|
Binding
|
|||
Unknown
|
Sialic acid (α2,6)
|
Saccharides
|
Most organs including the central nervous system/heart/liver
|
NeuAc(a2-6)
|
Binding
|
||
Unknown
|
Sialic acid (α2,3)
|
Saccharides
|
Most organs including the central nervous system/heart/liver
|
NeuAc(a2-3)
|
Binding
|
||
Unknown
|
Junctional adhesion molecule A (JAM-A)
|
Glycoproteins
|
Most organs including the central nervous system/heart/liver
|
Binding
|
|||
Botulinum neurotoxin (type C)
|
GD1b
|
Disialoglycosphingolipids
|
Presynaptic neuronal cells
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
BoNT/C (located within amino acid residues 1122-1290)
|
GD1b
|
Disialoglycosphingolipids
|
Presynaptic neuronal cells
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
Botulinum neurotoxin (type C)
|
GT1b
|
Trisialoglycosphingolipids
|
Presynaptic neuronal cells
|
NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
BoNT/C (located within amino acid residues 1122-1290)
|
GT1b
|
Trisialoglycosphingolipids
|
Presynaptic neuronal cells
|
NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
Botulinum neurotoxin (type D)
|
Phosphatidylethanolamine (PE)
|
Non-glycosylated Lipids
|
Presynaptic neuronal cells
|
Binding
|
|||
BoNT/D (two lysine residues (K1117 and K1135 in Hc/D1))
|
Phosphatidylethanolamine (PE)
|
Non-glycosylated Lipids
|
Presynaptic neuronal cells
|
Binding
|
GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.
Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01