GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name ▲	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Escherichia coli	Type 1-fimbriae	unnamed ligand	Oligosaccharides	Urine	Man(a1-3)Man(a1-6)Man	Binding	16564136
Clostridium difficile	Toxin A	unnamed ligand	Oligosaccharides	Human colonic cells	GalNAc(b1-3)Gal(b1-4)GlcNAc	Binding	12507507
Clostridium difficile	C-terminal domain of toxin A molecules	unnamed ligand	Oligosaccharides	Human colonic cells	GalNAc(b1-3)Gal(b1-4)GlcNAc	Binding	12507507
Neisseria gonorrhoeae	Adhesins	unnamed ligand	Oligosaccharides	Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva	Gal(b1-4)GlcNAc(b1-4)Gal(b1-4)Glc	Binding	2115881
Neisseria gonorrhoeae	18-kDa proteins	unnamed ligand	Oligosaccharides	Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva	Gal(b1-4)GlcNAc(b1-4)Gal(b1-4)Glc	Binding	2115881
Actinomyces viscosus	Unknown	unnamed ligand	Polyglycosylceramides	Rat small intestine	GalNAc(b1-3)[Gal(a1-3)]nGal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	2358461
Shigella dysenteriae	B subunit	unnamed ligand	Polyglycosylceramides	Rat small intestine	GalNAc(b1-3)[Gal(a1-3)]nGal(a1-4)Gal(b1-4)Glc(b1-1)Cer *n=1-5	Not Binding	3543013
Shigella dysenteriae	Shiga toxin	unnamed ligand	Sialoglycosphingolipids		NeuAc(a2-6)[NeuAc(a2-3)]Gal(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	2435422
Rotavirus	Unknown	unnamed ligand	Sialoglycosphingolipids		Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	11160731
Escherichia coli	Unknown	unnamed ligand	Sialoglycosphingolipids		NeuAc(a2-6)[NeuAc(a2-3)]Gal(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	2435422