GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Binding	PubMed ID
Paramyxovirus	Unknown	116 kDa glycoprotein (containing sialic acid residues with N-linked glycans)	N-glycans	Neurones of all brain regions	Binding	11666031
Polyoma virus	Capsid VP1	GD1a-GT1b analog	Sialoglycosphingolipids	(broad range)	Binding	18809496
Pseudomonas aeruginosa	Type 4-pili	Surface-localized glycoconjugates (non-sialylated GSL and glycoproteins)	Glycoconjugates	Human epithelial cells	Binding	9224879
Paracoccidioides brasiliensis	Adhesins	Fibrinogen	Glycoproteins	Human type II alveolar cells (A549)	Binding	18083324
Neisseria meningitidis	Type 4-pili	Agglutinin glycoproteins containing O-/N-linked (poly)lactosamine and hybrid oligosaccharides	Glycoproteins	Human saliva	Binding	16177210
Mycoplasma pneumoniae	Adhesins	hCG (human chorionic gonadotropin)	Glycoproteins	Erythrocytes	Binding	2470754
Bordetella pertussis	FimD	VLA-5 (very late activation antigen 5)	Glycoproteins	Monocytes	Binding	11348687
Foot-and-mouth disease virus	VP1 protein (RGD motif)	αvβ3 Integrin	Glycoproteins	BHK-21/LLC-MK2/HeLa/BK-LF	Binding	7533862
Staphylococcus aureus	Unknown	MUC16 mucin	Glycoproteins	Human corneal-limbal epithelial(HCLE) cells	Binding	17898272
Reovirus	Unknown	Junctional adhesion molecule A (JAM-A)	Glycoproteins	Most organs including the central nervous system/heart/liver	Binding	18216114