GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature ▲	Target Source	Glycan Sequence	Binding	PubMed ID
Escherichia coli	PsaA/B (pH-6 antigen)	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	9712817
Influenza virus	Unknown	GT1a	Trisialoglycosphingolipids		NeuAc(a2-8)NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	7870741
Influenza virus	Unknown	GT3	Trisialoglycosphingolipids		NeuAc(a2-8)NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	7870741
Influenza virus	Unknown	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	7870741
Rotavirus	Unknown	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	11160731
Yersinia pestis	PsaA/B (pH-6 antigen)	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	9712817
Cytomegalovirus	Unknown	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	9780061
Helicobacter pylori	Unknown	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	9169796
Clostridium botulinum	Botulinum neurotoxin	GT1b (complex with synaptotagmin II)	Trisialoglycosphingolipids	Presynaptic membrane of neuromuscular junction		Binding	7527117
Clostridium botulinum	BoNT/B	GT1b (complex with synaptotagmin II)	Trisialoglycosphingolipids	Presynaptic membrane of neuromuscular junction		Binding	7527117