GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule ▲	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Pseudomonas aeruginosa	exoenzyme S	Asialo-GM2 (Gangliotriosylceramide; GgO3)	Oligoglycosylceramides	Epithelial cells	GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	9224879
Pseudomonas aeruginosa	exoenzyme S	Phosphatidylethanolamine (PE)	Non-glycosylated Lipids	Epithelial cells		Binding	9224879
Pseudomonas aeruginosa	exoenzyme S	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Epithelial cells	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	9224879
Herpes virus	gH/gL	GAGs (glycosaminoglycans)	Glycosaminoglycans			Binding	18301747
Human immunodeficiency virus	gp120	Sulfatide (CSE)	Sulfoglycosphingolipids	Human U373-MG glioma and SK-N-MC neuroblastoma cells, Human colon epithelial HT29 cells	HSO3(-3)Gal(b1-1)Cer	Binding	15973004
Human immunodeficiency virus	gp120	Galactosylceramide (Galactocerebroside)	Monoglycosylceramides	Human colonic epithelial cell lines (HT-29/HT-29-A7/HT-29-D4)	Gal(b1-1)Cer	Binding	8464878
Human immunodeficiency virus	gp120	Galactosylceramide (Galactocerebroside)	Monoglycosylceramides	Human U373-MG glioma and SK-N-MC neuroblastoma cells, Human colon epithelial HT29 cells	Gal(b1-1)Cer	Binding	15973004
Herpes virus	gp70	GAGs (glycosaminoglycans)	Glycosaminoglycans			Binding	18301747
Escherichia coli	hLT	Blood group A antigen analog	Oligosaccharides			Binding	18809496
Reovirus	sigma 1 proteins	Sialic acid	Monosaccharides	Murine intestine, Murine spleen, Murine liver, Murine brain, Human cholangiocarcinoma cells		Binding	12813018