GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source ▲	Glycan Sequence	Binding	PubMed ID
Helicobacter pylori	HP0721	Sialyl Lewis x (SLex) antigen	Oligosaccharides	Gastric epithelial progenitors (GEPs)	NeuAc(a2-3)Gal(b1-4)	Binding	16406776
Helicobacter pylori	Fibrillar hemmagglutinin	N-acetylneuraminyl-a(2-3)-galactopyranosyl sequence	Glycoproteins	Gastric epithelium, Mucus layer of the stomach	NeuAc(a2-3)Gal	Binding	2459065
Neisseria gonorrhoeae	Unknown	N-acetyllactosamine (LacNAc)	Disaccharides	Genitalium	Gal(b1-4)GlcNAc	Binding	16564136
Escherichia coli	Verotoxin (1; B-subunit)	CD77 (Globotriaosylceramide; Gb3)	Oligoglycosylceramides	Germinal center B lymphocytes, Burkitt's lymphoma cells	Gal(a1-4)Gal	Binding	7516406
Escherichia coli	Unknown	CD77 (Globotriaosylceramide; Gb3)	Oligoglycosylceramides	Germinal center B lymphocytes, Burkitt's lymphoma cells	Gal(a1-4)Gal	Binding	7516406
Borrelia afzelii	Unknown	Dermatan sulfate	Glycosaminoglycans	Glial cells		Binding	10085013
Borrelia burgdorferi	Unknown	Dermatan sulfate	Glycosaminoglycans	Glial cells		Binding	10085013
Plasmodium falciparum	Unknown	Sialic acid	Monosaccharides	Glycophorins A/B on the erythrocyte membrane		Binding	3308959
Neisseria gonorrhoeae	Lectin-like proteins (adhesin)	isoGb3 (Isoglobotriaosylceramide; iGb3)	Oligoglycosylceramides	Gonorrhoeae patients	Gal(a1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	2468365
Neisseria gonorrhoeae	Lectin-like proteins (adhesin)	Asialo-GM2 (Gangliotriosylceramide; GgO3)	Oligoglycosylceramides	Gonorrhoeae patients	GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	2468365