GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source ▲	Glycan Sequence	Binding	PubMed ID
Paramyxovirus	Hemagglutinin H1(1934)	Human and avian receptors containing sialylated glycoconjugates	Glycoconjugates	Airways		Binding	18809496
Pseudomonas aeruginosa	PA-IIL	Lewis a (Lea) (GSL)	Glycosphingolipids	Airways	Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	18809496
Pseudomonas aeruginosa	Unknown	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Apical membrane of cystic fibrosis epithelia	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7708767
Staphylococcus aureus	Unknown	Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1)	Oligoglycosylceramides	Apical membrane of cystic fibrosis epithelia, Patients with pneumonia	Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	7708767
Influenza virus	Residues 226 (glutamine) and 228 (glycine)	Sialic acid linked to α2,3Galβ1,3GalNAc	Oligosaccharides	Avian/equine isolates	NeuAc(a2-3)Gal(b1-3)GalNAc	Binding	7975212
Coronavirus	Unknown	MHVR (murine member of the carcinoembryonic antigen family of glycoproteins)	Glycoproteins	BHK-21 cells		Binding	1318394
Foot-and-mouth disease virus	VP1 protein (RGD motif)	αvβ3 Integrin	Glycoproteins	BHK-21/LLC-MK2/HeLa/BK-LF		Binding	7533862
Escherichia coli	Type 1-pili	D-Mannose	Monosaccharides	Bladder epithelium	Man	Binding	12010488
Escherichia coli	FimCH-chaperone-adhesin complex	D-Mannose	Monosaccharides	Bladder epithelium	Man	Binding	12010488
Neisseria meningitidis	Type 4-pili	Thyroglobulin containing N-linked complex and hybrid (oligomannosidic) glycans	Glycoproteins	Bovine		Binding	16177210