Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Database | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule ▲ | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
|
BabA (blood group antigen binding adhesin)
|
Blood group B-Lewis b (BLeb) antigen
|
Oligosaccharides
|
Gal(a1-3)[Fuc(a1-2)]Gal(b1-3)[Fuc(a1-4)]GlcNAc
|
Binding
|
|||
|
BabA (blood group antigen binding adhesin)
|
Blood group A-Lewis b (ALeb) antigen
|
Oligosaccharides
|
GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)[Fuc(a1-4)]GlcNAc
|
Binding
|
|||
|
BabA (blood group antigen binding adhesin)
|
Blood group A antigen
|
Oligosaccharides
|
GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)GlcNAc
|
Binding
|
|||
|
BoNT/B
|
GT1b (complex with synaptotagmin II)
|
Trisialoglycosphingolipids
|
Presynaptic membrane of neuromuscular junction
|
Binding
|
|||
|
BoNT/C (located within amino acid residues 1122-1290)
|
GD1b
|
Disialoglycosphingolipids
|
Presynaptic neuronal cells
|
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
|
BoNT/C (located within amino acid residues 1122-1290)
|
GT1b
|
Trisialoglycosphingolipids
|
Presynaptic neuronal cells
|
NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
||
|
BoNT/D (two lysine residues (K1117 and K1135 in Hc/D1))
|
Phosphatidylethanolamine (PE)
|
Non-glycosylated Lipids
|
Presynaptic neuronal cells
|
Binding
|
|||
|
Botulinum neurotoxin
|
GT1b
|
Trisialoglycosphingolipids
|
NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
|
Binding
|
|||
|
Botulinum neurotoxin
|
GT1b (complex with synaptotagmin II)
|
Trisialoglycosphingolipids
|
Presynaptic membrane of neuromuscular junction
|
Binding
|
|||
|
Botulinum neurotoxin (16S)
|
Lactose
|
Disaccharides
|
Intestinal epithelial cells (T84)
|
Gal(b1-4)Glc
|
Binding
|
Displaying entries 191 - 200 of 1840 in total
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International Collaboration
GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.
Acknowledgements
Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
