GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source ▼	Glycan Sequence	Binding	PubMed ID
Escherichia coli	S-fimbriae	unnamed ligand	Oligosaccharides	Neural cell lines	NeuAc(a2-3)Gal(b1-3)GalNAc	Binding	16564136
Human immunodeficiency virus	HIV surface glycoprotein gp120	Galactosylceramide (Galactocerebroside)	Monoglycosylceramides	Neural cell lines	Gal(b1-1)Cer	Binding	1857969
Streptococcus agalactiae	Unknown	Salivary glycoprotein (gp340)	Glycoproteins	Neonatal meningitis		Binding	11007786
Streptococcus pneumoniae	PsaA (Lary family)	unknown carbohydrate ligand	Saccharides	Nasopharynx, Alveolar epithelial cells		Binding	10341176
Polyoma virus	Unknown	unnamed ligand	Oligosaccharides	Murine small plaque	NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc	Binding	8574698
Histoplasma capsulatum	Lectin-like component	Galactosylated surface molecules (mainly β-anomer)	Glycoconjugates	Murine macrophages		Binding	19547878
Reovirus	sigma 1 proteins	Sialic acid	Monosaccharides	Murine intestine, Murine spleen, Murine liver, Murine brain, Human cholangiocarcinoma cells		Binding	12813018
Mycoplasma pneumoniae	Adhesins	Laminin	Glycoproteins	Murine Engelbreth Holm Swarm tumor, Murine erythrocytes		Binding	2470754
Helicobacter pylori	SabA (sialic acid-binding adhesin)	Fucosylated Lewis b (Leb) histoblood group antigens	Oligosaccharides	Mucosal surface of the gastric epithelium		Binding	12640357
Neisseria gonorrhoeae	36-kDa proteins	Asialo-GM2 (Gangliotriosylceramide; GgO3)	Oligoglycosylceramides	Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva	GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	2115881