GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species ▲	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Clostridium botulinum	BoNT/C (located within amino acid residues 1122-1290)	GD1b	Disialoglycosphingolipids	Presynaptic neuronal cells	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	Botulinum neurotoxin (type C)	GT1b	Trisialoglycosphingolipids	Presynaptic neuronal cells	NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	BoNT/C (located within amino acid residues 1122-1290)	GT1b	Trisialoglycosphingolipids	Presynaptic neuronal cells	NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	Progenitor toxin (type A)	Lactose	Disaccharides	Intestine-407 cells	Gal(b1-4)Glc	Binding	15850798
Clostridium botulinum	Progenitor toxin (type A)	N-acetyllactosamine (LacNAc)	Disaccharides	Intestine-407 cells	Gal(b1-4)GlcNAc	Binding	15850798
Clostridium botulinum	Botulinum neurotoxin (16S)	Lactose	Disaccharides	Intestinal epithelial cells (T84)	Gal(b1-4)Glc	Binding	17156748
Clostridium botulinum	HA	Lactose	Disaccharides	Intestinal epithelial cells (T84)	Gal(b1-4)Glc	Binding	17156748
Clostridium botulinum	Unknown	Lactose	Disaccharides	Intestine-407 cells	Gal(b1-4)Glc	Binding	15850798
Clostridium botulinum	Unknown	N-acetyllactosamine (LacNAc)	Disaccharides	Intestine-407 cells	Gal(b1-4)GlcNAc	Binding	15850798
Clostridium botulinum	Botulinum neurotoxin (16S)	N-Acetylgalactosamine	Monosaccharides	Intestinal epithelial cells (T84)	GalNAc	Binding	17156748