GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species ▲	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Clostridium botulinum	Botulinum neurotoxin (16S)	Galactose	Monosaccharides	Intestinal epithelial cells (T84)	Gal	Binding	17156748
Clostridium botulinum	HA	N-Acetylgalactosamine	Monosaccharides	Intestinal epithelial cells (T84)	GalNAc	Binding	17156748
Clostridium botulinum	HA	Galactose	Monosaccharides	Intestinal epithelial cells (T84)	Gal	Binding	17156748
Clostridium botulinum	Neurotoxin (type B)	GD1a	Disialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	9712688
Clostridium botulinum	Unknown	GD1a	Disialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	9712688
Clostridium botulinum	Neurotoxin (type A/B)	GM2(NeuAc)	Monosialoglycosphingolipids		GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	15973004
Clostridium botulinum	Unknown	GM2(NeuAc)	Monosialoglycosphingolipids		GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	15973004
Clostridium botulinum	Neurotoxin (type B)	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	9712688
Clostridium botulinum	Botulinum neurotoxin	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	12628483
Clostridium botulinum	Unknown	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	9712688