GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name ▼	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Foot-and-mouth disease virus	VP1 (RGD peptide)	αvβ3 Integrin (independent of expression of Heparan sulfate on cell-sulface)	Glycoproteins	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 protein (RGD motif)	αvβ3 Integrin	Glycoproteins	BHK-21/LLC-MK2/HeLa/BK-LF		Binding	7533862
Escherichia coli	SafS	α-sialyl-2-3-β-galactose	Disaccharides			Binding	12640357
Equine rhinitis A virus	Viral protein	α-mannose and α-glucose side chains of ConA-binding glycoproteins	Glycoproteins	Feline kidney(CRFK)/Equine fetal kidney(EFK)/Mouse(McCoy)/Rabbit kidney(RK-13)	Man/Glc	Binding	15302947
Shigella dysenteriae	B subunit	α-hydroxylated Gb3	Oligoglycosylceramides			Binding	3519828
Escherichia coli	S-fimbriae	α-Sialyl-2,3-lactose-containing receptors	Saccharides			Binding	11401961
Listeria monocytogenes	Unknown	α-GalCer/CD1d tetramers	Glycoconjugates	V[alpha]14+ NK1.1- T cells in infected liver of mice		Binding	16988270
Clostridium difficile	Toxin A	α-Gal on Fab of IgM(λ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079
Clostridium difficile	Unknown	α-Gal on Fab of IgM(λ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079
Clostridium difficile	Toxin A	α-Gal on Fab of IgA(κ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079