GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source ▲	Glycan Sequence	Binding	PubMed ID
Clostridium difficile	Toxin A	unnamed ligand	Oligosaccharides	Human colonic cells	GalNAc(b1-3)Gal(b1-4)GlcNAc	Binding	12507507
Clostridium difficile	C-terminal domain of toxin A molecules	unnamed ligand	Oligosaccharides	Human colonic cells	GalNAc(b1-3)Gal(b1-4)GlcNAc	Binding	12507507
Human immunodeficiency virus	gp120	Galactosylceramide (Galactocerebroside)	Monoglycosylceramides	Human colonic epithelial cell lines (HT-29/HT-29-A7/HT-29-D4)	Gal(b1-1)Cer	Binding	8464878
Escherichia coli	P-pili	Surfactant-like particles (SLP)	Non-glycosylated Lipids	Human colonocytes and enterocytes		Binding	10531281
Escherichia coli	PapD-PapG (class I)	Surfactant-like particles (SLP)	Non-glycosylated Lipids	Human colonocytes and enterocytes		Binding	10531281
Haemophilus influenzae	Hia	Oligosaccharides rich in sialic acid	Oligosaccharides	Human conjunctival cells (respiratory tract)		Binding	12640357
Haemophilus influenzae	Hia	unknown carbohydrate ligand	Saccharides	Human conjunctival cells (respiratory tract)		Binding	10341176
Adenovirus	Fibre proteins	HSA glycoconjugates	Glycoproteins	Human corneal epithelial(HEC) cells		Binding	15678425
Staphylococcus aureus	Unknown	MUC16 mucin	Glycoproteins	Human corneal-limbal epithelial(HCLE) cells		Binding	17898272
Streptococcus pneumoniae	Adhesins	GlcNAc(b1-3)Gal sequence	Saccharides	Human endothelial cells	GlcNAc(b1-3)Gal	Binding	6886624