GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature ▲	Target Source	Binding	PubMed ID
Helicobacter pylori	Adhesins	Fetuin	Glycoproteins	Human leukocytes, Human neutrophils	Binding	10569742
Escherichia coli	K99	Mucin	Glycoproteins	Intestinal cells	Binding	7849044
Neisseria meningitidis	Type 4-pili	Thyroglobulin containing N-linked complex and hybrid (oligomannosidic) glycans	Glycoproteins	Bovine	Binding	16177210
Bordetella pertussis	Pertussis toxin	Fetuin	Glycoproteins	Bovine	Binding	14532091
Helicobacter pylori	Unknown	Salivary glycoprotein (gp340)	Glycoproteins	Human stomach associated with gastritis and peptic ulcer disease	Binding	11007786
Foot-and-mouth disease virus	VP1 (RGD peptide)	αvβ3 Integrin (independent of expression of Heparan sulfate on cell-sulface)	Glycoproteins	Extracellular matrix (ECM)	Binding	9557639
Foot-and-mouth disease virus	RGD motif of the VP1 GH loop	αvβ6 Integrin	Glycoproteins	Epithelial cells	Binding	10799568
Streptococcus agalactiae	Unknown	Salivary glycoprotein (gp340)	Glycoproteins	Neonatal meningitis	Binding	11007786
Pseudomonas aeruginosa	Adhesins	MUC1 mucin	Glycoproteins	Surface of chinese hamster ovary (CHO) cells	Binding	11133508
Streptococcus gordonii	SspA (Antigen I/II)	Salivary glycoprotein	Glycoproteins	Saliva	Binding	12640357