GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule ▼	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Foot-and-mouth disease virus	VP1 (RGD peptide)	αvβ3 Integrin (independent of expression of Heparan sulfate on cell-sulface)	Glycoproteins	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparin	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface)	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface)	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface)	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface)	Glycosaminoglycans	Extracellular matrix (ECM)		Binding	9557639
Foot-and-mouth disease virus	VP1 (RGD peptide)	Heparin	Glycosaminoglycans	Extracellular matrix (ECM)		Not Binding	9557639
Actinomyces naeslundii	Unknown	GD1b	Disialoglycosphingolipids	Human brain	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	2358461
Clostridium tetani	Unknown	GD1b	Disialoglycosphingolipids	Brain membrane	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	6257717
Norovirus	Unknown	Sialylated type 2 chain conjugates (S-type 2-HSA)	Glycoproteins	Human serum albumin	NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD	Binding	19054801