GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID ▼
Escherichia coli	Shiga-like toxin (Stx1)	Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH)	Oligoglycosylceramides		Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	18541402
Rotavirus	VP8	Sialic acid	Monosaccharides			Binding	18540062
Herpes virus	gH/gL	GAGs (glycosaminoglycans)	Glycosaminoglycans			Binding	18301747
Herpes virus	gp70	GAGs (glycosaminoglycans)	Glycosaminoglycans			Binding	18301747
Clostridium botulinum	Botulinum neurotoxin (type C)	GD1b	Disialoglycosphingolipids	Presynaptic neuronal cells	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	BoNT/C (located within amino acid residues 1122-1290)	GD1b	Disialoglycosphingolipids	Presynaptic neuronal cells	Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	Botulinum neurotoxin (type C)	GT1b	Trisialoglycosphingolipids	Presynaptic neuronal cells	NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	BoNT/C (located within amino acid residues 1122-1290)	GT1b	Trisialoglycosphingolipids	Presynaptic neuronal cells	NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	18242046
Clostridium botulinum	Botulinum neurotoxin (type D)	Phosphatidylethanolamine (PE)	Non-glycosylated Lipids	Presynaptic neuronal cells		Binding	18242046
Clostridium botulinum	BoNT/D (two lysine residues (K1117 and K1135 in Hc/D1))	Phosphatidylethanolamine (PE)	Non-glycosylated Lipids	Presynaptic neuronal cells		Binding	18242046