GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence ▲	Binding	PubMed ID
Propionibacterium granulosum	Unknown	H5 type 2 pentaglycosylceramide (neolacto-series)	Oligoglycosylceramides		Fuc(a1-2)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	2435422
Escherichia coli	K88ab/K88ac/K88ad	Fuc-nLc6 (VI2)	Oligoglycosylceramides		Fuc(a1-2)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	11953368
Helicobacter pylori	Neutrophil-activating proteins (150-kDa)	unnamed ligand	Sialoglycosphingolipids	Human erythrocytes	Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	9228091
Clostridium difficile	Toxin A	α-Gal on Fab of IgA(κ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079
Clostridium difficile	Toxin A	α-Gal on Fab of IgM(λ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079
Clostridium difficile	Unknown	α-Gal on Fab of IgA(κ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079
Clostridium difficile	Unknown	α-Gal on Fab of IgM(λ) MAb	Glycoproteins	Mouse	Gal	Binding	9573079
Actinomyces naeslundii	Type-2 fimbrial lectins (130-kDa glycoprotein)	Galactose	Monosaccharides	Polymorphonuclear leukocytes (PMNs)	Gal	Binding	7790078
Entamoeba histolytica	Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa).	Galactose	Monosaccharides	Intestinal cells	Gal	Binding	15322032
Entamoeba histolytica	Gal/GalNAc Lectins (260-kDa)	Galactose	Monosaccharides	c-Met on hepatocytes	Gal	Binding	9878032