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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding ▲ | PubMed ID |
|---|---|---|---|---|---|---|---|
| Entamoeba histolytica | Raft-like plasma membrane domains | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Reovirus | Unknown | Junctional adhesion molecule A (JAM-A) | Glycoproteins | Most organs including the central nervous system/heart/liver | Binding | 18216114 | |
| Borrelia burgdorferi | Unknown | Heparin (N-desulfated, N-acetylated) | Glycosaminoglycans | Vero cells | Binding | 9826395 | |
| Human immunodeficiency virus | Unknown | NAC-heparin (non-anticoagulant heparin) | Glycosaminoglycans | Human T cells | Binding | 9420059 | |
| Chlamydia trachomatis | Unknown | NAC-heparin (non-anticoagulant heparin) | Glycosaminoglycans | HeLa cells | Binding | 9420059 | |
| Herpes simplex virus | Unknown | NAC-heparin (non-anticoagulant heparin) | Glycosaminoglycans | Human cervical cells | Binding | 9420059 | |
| Neisseria gonorrhoeae | Unknown | NAC-heparin (non-anticoagulant heparin) | Glycosaminoglycans | Human epithelial cells | Binding | 9420059 | |
| Helicobacter pylori | Adhesins | PGCs (polyglycosyl ceramides) | Glycosphingolipids | Human leukocytes, Human neutrophils | Binding | 10569742 | |
| Influenza virus | Hemagglutinin (HA) | Gangliosides | Glycosphingolipids | Human leukocytes | Binding | 11030743 | |
| Helicobacter pylori | Unknown | PGCs (polyglycosyl ceramides) | Glycosphingolipids | Human erythrocytes, Human leukocytes, Human placenta | Binding | 9169796 | |
| Helicobacter pylori | Unknown | PGCs (polyglycosyl ceramides) | Glycosphingolipids | Rat small intestine, Wild boar intestine, Monkey intestine | Binding | 9169796 | |
| Pseudomonas aeruginosa | LecB | alpha-methyl-fucoside | Monosaccharides | A549 cells | Binding | 19237519 | |
| Pseudomonas aeruginosa | LecA | Alpha-methyl-galactoside | Monosaccharides | A549 cells | Binding | 19237519 | |
| Escherichia coli | K88ab | GlcNAc residues in the core of N-glycan on pSTf (porcine serum transferrin) | N-glycans | Porcine serum | Binding | 11953368 | |
| Shigella dysenteriae | Adhesins | Lipid extracts of Hep-2 cells | Non-glycosylated Lipids | HEp-2 cells | Binding | 11381327 | |
| Escherichia coli | P-pili | Surfactant-like particles (SLP) | Non-glycosylated Lipids | Human colonocytes and enterocytes | Binding | 10531281 | |
| Escherichia coli | PapD-PapG (class I) | Surfactant-like particles (SLP) | Non-glycosylated Lipids | Human colonocytes and enterocytes | Binding | 10531281 | |
| Lassa virus | Glycoprotein (GP) | O-mannosyl glycans on alpha-dystroglycan (DG) | O-glycans | Fibroblasts, Epithelial cells, Endothelial cells, Hepatocytes | Binding | 17360738 | |
| Lymphocytic choriomeningitis virus | Glycoprotein (GP) | O-mannosyl glycans on alpha-dystroglycan (DG) | O-glycans | Fibroblasts, Epithelial cells, Endothelial cells, Hepatocytes | Binding | 17360738 | |
| Borrelia burgdorferi | DbpA | Decorin | Proteoglycans | Extracellular matrix (ECM) | Binding | 12761224 | |
| Histoplasma capsulatum | Lectin-like component | unknown carbohydrate ligand | Saccharides | Human erythrocytes | Binding | 19547878 | |
| Haemophilus influenzae | HMW1 | unknown carbohydrate ligand | Saccharides | Human epithelial cells (respiratory tract) | Binding | 10341176 | |
| Haemophilus influenzae | HMW2 | unknown carbohydrate ligand | Saccharides | Human epithelial cells (respiratory tract) | Binding | 10341176 | |
| Streptococcus gordonii | SspA/SspB (AgI/II family) | unknown carbohydrate ligand | Saccharides | Platelet | Binding | 16177339 | |
| Escherichia coli | AC/I-fimbriae (S-fimbrial family) | unknown carbohydrate ligand | Saccharides | Septicemic avian epithelial cells | Binding | 10992500 |
