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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature ▼ | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Polyoma virus | Capsid protein VP1 | Sialylated oligosaccharides | Oligosaccharides | Cell surface | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 8805524 |
| Helicobacter pylori | Unknown | unnamed ligand | Oligosaccharides | Stomach | NeuAc(a2-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Polyoma virus | Unknown | Sialylated oligosaccharides | Oligosaccharides | Erythrocytes | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 6316632 |
| Escherichia coli | K99 | unnamed ligand | Oligosaccharides | Intestinal cells | NeuAc(a2-3)Gal(b1-4)Glc | Binding | 16564136 |
| Influenza virus | Residues 226 (glutamine) and 228 (glycine) | Sialic acid linked to α2,3Galβ1,3GalNAc | Oligosaccharides | Avian/equine isolates | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 7975212 |
| Polyoma virus | Unknown | unnamed ligand | Oligosaccharides | Murine small plaque | NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc | Binding | 8574698 |
| Haemophilus influenzae | HMW1 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | HMW2 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | Hia | Oligosaccharides rich in sialic acid | Oligosaccharides | Human conjunctival cells (respiratory tract) | Binding | 12640357 | |
| Actinomyces naeslundii | Type-2 fimbrial lectins (130-kDa glycoprotein) | unnamed ligand | Oligosaccharides | Polymorphonuclear leukocytes (PMNs) | Gal(b1-3)GalNAc | Binding | 7790078 |
| Streptococcus suis | PO | unnamed ligand | Oligosaccharides | human erythrocytes | Gal(a1-4)Gal | Binding | 7499414 |
| Escherichia coli | Type 1-fimbriae | trisaccharide: Man(a1-3)Man(b1-4)GlcNAc | Oligosaccharides | Patient with urinary tract infection | Man(a1-3)Man(b1-4)GlcNAc | Binding | 6138149 |
| Clostridium difficile | Toxin A | unnamed ligand | Oligosaccharides | Human colonic cells | Gal(a1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Clostridium difficile | C-terminal domain of toxin A molecules | unnamed ligand | Oligosaccharides | Human colonic cells | Gal(a1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Streptococcus suis | PN | unnamed ligand | Oligosaccharides | human erythrocytes | Gal(a1-4)Gal | Binding | 7499414 |
| Legionella pneumophila | Adhesins | unnamed ligand | Oligosaccharides | Human epithelial cells (respiratory tract) | Gal(b1-4)GlcNAc | Binding | 14687561 |
| Escherichia coli | FimH | Mannose oligosaccharides | Oligosaccharides | Eukaryotic cells | Man | Binding | 12640357 |
| Haemophilus influenzae | Unknown | Tetrasaccharides | Oligosaccharides | Respiratory tract | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Campylobacter jejuni | Unknown | unnamed ligand | Oligosaccharides | Intestinal cells | Fuc(a1-2)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Pseudomonas aeruginosa | Unknown | unnamed ligand | Oligosaccharides | Respiratory tract | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc | Binding | 16564136 |
| Streptococcus pneumoniae | Unknown | unnamed ligand | Oligosaccharides | Chinchilla tubotympanum | Gal(b1-4)GlcNAc(b1-3)Gal(b | Binding | 1298868 |
| Streptococcus pneumoniae | Unknown | Tetrasaccharides | Oligosaccharides | Respiratory tract | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Streptococcus suis | Unknown | unnamed ligand | Oligosaccharides | Respiratory tract | Gal(a1-4)Gal(b1-4)Glc | Binding | 16564136 |
| Neisseria meningitidis | Unknown | Tetrasaccharides | Oligosaccharides | Respiratory tract | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Helicobacter pylori | SabA (sialic acid-binding adhesin) | Fucosylated Lewis b (Leb) histoblood group antigens | Oligosaccharides | Mucosal surface of the gastric epithelium | Binding | 12640357 |
