VEGFA-VEGFR2 Pathway

Summary
Species
Caenorhabditis elegans
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ATPActive MAPKAP kinaseADPMAPKAP kinaseRHOA:GTPRHOA:GTP:ROCK1,ROCK2ROCK1,ROCK2RHOA:GTP:Mg2+:Activated ROCK1,ROCK2PTK2BVEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2BVEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXLHomologues of AXLVEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXLPI3KVEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3KPIP2PIP3RAC1:GDPp-VAV family:PIP3:RAC1:GDPp-VAV family:PIP3GDPGTPp-VAV family:PIP3:RAC1:GTPVEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYNVEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYNVEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYNVEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2PAK2 dimerCDC42:GTPVEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTPVEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTPVEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTPMAP kinase p38 (Mg2+ cofactor)Phospho-MAP kinase p38 (Mg2+ cofactor)Homologues of p-S15,S78,S82-HSP27HSP27 oligomer:F-actinF-actin
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025